Intravenous Midazolam - Role in the Treatment of Hyperventilation Syndrome

Abstract

PURPOSE: To determine, the epidemiological characteristics and risk factors predisposing to fungal keratitis in Hubli, south India. To know the importance of KOH wet mount for rapid detection of fungal keratitis for institution of antifungal therapy as earliest possible. To know the statistical significance regarding the common type of fungi that involves the cornea and prognosis with regard to the available mode of therapy and their results. METHOD: In one year period, out of 112 patients presented with corneal ulcer, 48 (42.85%) were clinically suspected as having mycotic keratitis. Sensitivity of KOH wet mount preparation in our study is 96.25% in our study. Fusarium (53.84%) was most commonly isolated fungus. In our study all 48 cases were treated with Monotherapy, in that 28 cases patients deep stromal involvement were treated with combined therapy. About 15 patients received surgical treatment. 17(35.41%) cases had only HM positive and one case (2.08%) with only perception of light. and 2(6.25%) cases with no perception and rest had fairly good vision. CONCLUSION: These findings have important public health implications for the early diagnosis in suspected cases of mycotic keratitis and institution of specific therapy at earliest to avoid hazardous effects on cornea. INTRODUCTION:corneal blindness accounts for 20-30 % of all blindness in developing countries of the world. Suppurative keratitis is the leading cause with mycotic keratitis constituting half of the cases in north Karnataka. Morbidity in mycotic infection tends to be higher compared to bacterial keratitis because diagnosis is often delayed due to negligence towards ocular trauma, inappropriate treatment and wide spread use of topical antibiotics and steroids for any case of corneal ulcer.KIMS Hubli, being tertiary care hospital and major referral center, we get more than twothree cases of mycotic keratitis per OPD. Considering its prevalence it is thought worthwhile to take up clinical study of mycotic keratitis to diagnose the case on suspicion with laboratory investigation and to start antimycotic treatment early for better results. AIMS AND OBJECTIVES:Clinical study of mycotic keratitis concerns with: 1.To know the incidence of mycotic keratitis.