Intravenous nicardipine for the treatment of renovascular hypertension due to fibromuscular dysplasia during pregnancy: A case study

Abstract

Renovascular hypertension due to renal artery stenosis associated with fibromuscular dysplasia during pregnancy can lead to maternal and fetal complications. Although conventional percutaneous angiography and angioplasty are recommended for patients with renal artery stenosis due to fibromuscular dysplasia, the influence of these procedures on women and fetuses is unknown. A 27-year-old primigravida was diagnosed with renovascular hypertension possibly due to fibromuscular dysplasia. Percutaneous transluminal angioplasty in conjunction with renal angiography was initially planned, but she became pregnant and was referred to our department at 9 weeks of gestation. At 22 weeks of gestation, she was administered intravenous nicardipine (24-120 mg /day) for blood pressure control until 32 weeks of gestation. At 33 weeks 2 days of gestation, her hypertension was uncontrollable, and she delivered a healthy infant by cesarean section. Intravenous administration of nicardipine may present an effective and safe method to control blood pressure in women with fibromuscular dysplasia.