Intravenous nicardipine in the treatment of postoperative arterial hypertension

Vincent, Jean‐Louis; Berlot, Giorgio; Preiser, Jean-Charles; Engelman, Edgard; Dereume, Jean-Pierre; Khan, Robert J.

doi:10.1016/s1053-0770(97)90206-8

Cited by 35 publications

(18 citation statements)

References 34 publications

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“…A therapeutic benefit of nicardipine is that the agent has been demonstrated to increase both stroke volume and coronary blood flow with a favorable effect on myocardial oxygen balance (Lambert et al 1985, 1986, 1987; Schillinger 1987; Vincent et al 1997). This property is beneficial in patients with coronary artery disease and systolic heart failure.…”

Section: Pharmacotherapymentioning

confidence: 99%

Perioperative hypertension management

Varon¹

2008

VHRM

159

117

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Perioperative hypertension is commonly encountered in patients that undergo surgery. While attempts have been made to standardize the method to characterize the intraoperative hemodynamics, these methods still vary widely. In addition, there is a lack of consensus concerning treatment thresholds and appropriate therapeutic targets, making absolute recommendations about treatment diffi cult. Nevertheless, perioperative hypertension requires careful management. When treatment is necessary, therapy should be individualized for the patient. This paper reviews the pharmacologic agents and strategies commonly used in the management of perioperative hypertension.

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Section: Pharmacotherapymentioning

confidence: 99%

Perioperative hypertension management

Varon¹

2008

VHRM

159

117

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“…Nicardipine is very effective in the management of postoperative hypertension [83,118,[120][121][122][123][124]. Nicardipine has been given as an infusion or a bolus followed by an infusion, with drug titrated until a therapeutic response is achieved.…”

Section: Nicardipinementioning

confidence: 99%

“…Unlike nitroprusside, nicardipine is not associated with "coronary steal syndrome" [70]. Furthermore, nicardipine increases CO and coronary blood flow and favorably affects the balance between myocardial oxygen demand and supply [124].…”

Section: Nicardipinementioning

confidence: 99%

Perioperative hypertension: a review of current and emerging therapeutic agents,

Marik

Varon

2009

Journal of Clinical Anesthesia

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“…In cardiac surgical patients, nicardipine has been shown to decrease arterial BP acutely with no effects on ventricular preload or cardiac output, suggesting that it has a minimal negative inotropic action [31]. With nicardipine, oxygen delivery to the cells is usually well maintained and oxygen requirements are unchanged [8,32]. Because nicardipine is metabolized primarily by the liver, it can be used in patients with renal insufficiency.…”

Section: Management Of Emergency Hypertensionmentioning

confidence: 99%

Hypertensive Emergency in Aortic Dissection and Thoracic Aortic Aneurysm—A Review of Management

Gupta

Khoynezhad

2009

Pharmaceuticals

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Over the last few decades, treatment for aortic dissection and thoracic aortic aneurysms has evolved significantly with improvement in outcomes. Treatment paradigms include medical, endovascular and surgical options. As aortic dissection presents as a hypertensive emergency, diligent control of BP is of utmost importance in order to reduce the progression of dissection with possible aortic branch malperfusion. Treatment should begin on arrival to the emergency department and continues in the intensive care unit, endovascular suite or the operating room. Novel antihypertensive medications with improved pharmacological profile and improved surgical techniques, have improved the prognosis of patients with aortic aneurysm and/or aortic dissection. Nevertheless, morbidity and mortality remain high and hypertensive emergency poses a significant challenge in aortic dissection and thoracic aortic aneurysms.

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Intravenous nicardipine in the treatment of postoperative arterial hypertension

Cited by 35 publications

References 34 publications

Perioperative hypertension management

Perioperative hypertension management

Perioperative hypertension: a review of current and emerging therapeutic agents,

Hypertensive Emergency in Aortic Dissection and Thoracic Aortic Aneurysm—A Review of Management

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