Intravenous Nutrition and Postnatal Growth of the Micropremie

Thureen, Patti J.; Hay, William W.

doi:10.1016/s0095-5108(05)70014-2

Cited by 61 publications

(71 citation statements)

References 98 publications

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“…Theoretical calculations based on relatively stable infants submitted to mechanical ventilation on the first days of life indicate the necessity of at least 50 kcal/kg/day of energy for an amino acid intake of 2 g/kg/days and 60 kcal/kg/day for an amino acid intake of 3 g/kg/day. 56 These theoretical calculations support the clinical observation that most infants have a positive protein balance, receiving 50 to 60 kcal/kg/day of energy. 56 In the absence of protein intake, glucose is more of an effective energy substrate than lipids in the prevention of protein breakdown.…”

Section: Amino Acid and Protein Requirements Of Preterm Infantssupporting

confidence: 65%

“…56 These theoretical calculations support the clinical observation that most infants have a positive protein balance, receiving 50 to 60 kcal/kg/day of energy. 56 In the absence of protein intake, glucose is more of an effective energy substrate than lipids in the prevention of protein breakdown. When amino acids are offered, both glucose and lipids spare the protein catabolism, but the optimal glucose/lipid ratio for preterm infants is still unknown.…”

Section: Amino Acid and Protein Requirements Of Preterm Infantssupporting

confidence: 65%

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Dilemas nutricionais no pré-termo extremo e repercussões na infância, adolescência e vida adulta

Camelo¹,

Martinez²

2005

J. Pediatr. (Rio J.)

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Suggested citation: Camelo Jr. JS, Martinez FE. Nutritional dilemmas in extremely low birth weight infants and their effects on childhood, adolescence and adulthood. J Pediatr (Rio J). 2005;81(1 Suppl):S33-S42. AbstractObjective: To review the recent medical literature on nutrition of extremely low birth weight infants, focusing on nutritional dilemmas and their effects on childhood, adolescence and adulthood.Sources of data: An extensive review of the related literature was performed using MEDLINE, the Cochrane Database of Systematic Reviews and the Best Evidence database. Summary of the findings:There is a growing body of evidence that early nutritional practices may affect shortterm growth and development outcome. In addition, these practices may play a role in determining adult health and disease. There is still much to be learned about safe and efficacious nutrient administration in preterm infants; about techniques to assess the effect of different nutritional strategies; and about the long-term effects of these regimens on development outcome, growth and disease.Conclusion: Despite recent progress in neonatal nutrition, there is a lack of basic and clinical research to better define the nutritional requirements of preterm infants and the best way to meet these requirements, avoiding longterm undesirable consequences.J Pediatr (Rio J). 2005;81(1 Suppl):S33-S42: Nutrition, human milk, prematurity, parenteral nutrition, enteral nutrition, nutritional programming.

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Section: Amino Acid and Protein Requirements Of Preterm Infantssupporting

confidence: 65%

Section: Amino Acid and Protein Requirements Of Preterm Infantssupporting

confidence: 65%

Dilemas nutricionais no pré-termo extremo e repercussões na infância, adolescência e vida adulta

Camelo¹,

Martinez²

2005

J. Pediatr. (Rio J.)

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“…13 Higher urea and base deficit, and lower bicarbonate and pH values were identified when analyzed as a continuous measure similar to our study. We elected to start with intake of 1.4-1.6 g/kg/day as previous studies 17,18 suggested that 1-1.5 g/kg/day was sufficient to prevent a catabolic state and prevent consequent growth deficit for extremely low birth weight infants. Additionally, we increased the infusion rate of AA to reach the recommended protein intake within 3 days of start of TPN.…”

Section: Discussionmentioning

confidence: 99%

Safety and efficacy of early amino acids in preterm <28 weeks gestation: prospective observational comparison

et al. 2006

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Objective: To assess the safety and efficacy of early amino acid (AA) administration in preterm neonates <28 weeks gestational age.Study design: Prospective data collection for 1 year for the late AA group (AA started at 12-30 h) and for another year with practice change to early AA administration (immediately after stabilization).Results: Time of initiation of AA differed (early group 4±3 h vs late group 20±6 h; P<0.001). There were no statistically significant differences in the incidence of clinically significant metabolic acidosis. Blood urea at 24 h was higher in the early AA group. No significant differences in growth rate or neonatal outcomes were identified. Days to regain birth weight and sepsis were lower in the early AA group.Conclusions: Early AA administration was not associated with any clinically significant adverse effects; it was associated with reduction in the incidence of sepsis and marginally effective in reducing time to regain birth weight.

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“…[12][13][14] Early amino-acid supplementation dramatically improves the nitrogen balance of ELBW infants, shifting these patients from the catabolic state traditional parenteral support induces to a healthier anabolic state. [15][16][17] The ultimate goal of these three interventions is to improve short-and long-term outcomes. Our primary outcome measure was growth, as EUGR is associated with significantly lower Bayley Mental Development Index (MDI) and Psychomotor Index (PDI) scores at 2 years of age, 18 and impaired long-term growth potential.…”

Section: Introductionmentioning

confidence: 99%

Improved growth and decreased morbidities in <1000 g neonates after early management changes

et al. 2008

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Objective: To test the hypothesis that three changes in the early management of extremely low birth weight (ELBW) neonates would decrease the incidence of extra-uterine growth restriction (EUGR) by 25%. The three early management practice changes (EMPC) included surfactant at delivery followed by immediate extubation to nasal continuous positive airway pressure (CPAP), decreased oxygen exposure and early parenteral amino acids.

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Intravenous Nutrition and Postnatal Growth of the Micropremie

Cited by 61 publications

References 98 publications

Dilemas nutricionais no pré-termo extremo e repercussões na infância, adolescência e vida adulta

Dilemas nutricionais no pré-termo extremo e repercussões na infância, adolescência e vida adulta

Safety and efficacy of early amino acids in preterm <28 weeks gestation: prospective observational comparison

Improved growth and decreased morbidities in <1000 g neonates after early management changes

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