Intravenous or intramuscular parecoxib for acute postoperative pain in adults

Lloyd, Rosalind; Derry, Sheena; Moore, R Andrew; McQuay, Henry J

doi:10.1002/14651858.cd004771.pub4

Cited by 75 publications

(60 citation statements)

References 65 publications

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“…25,26 The efficacy of parecoxib for noncardiac postoperative analgesia is well described. [3][4][5][6] Parecoxib is rapidly converted to valdecoxib by hydrolysis after administration, 1,2 and analgesia is said to begin within 15 minutes of an intravenous or intramuscular injection. Valdecoxib is then extensively metabolized and most of its metabolites are excreted in the urine; this metabolism includes cytochrome P450 iso-enzymes 3A4 and 2C9.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Daily Subcutaneous Parecoxib Injection for Cancer Pain: An Open Label Pilot Study

Kenner

Bhagat

Fullerton

2015

Journal of Palliative Medicine

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Section: Discussionmentioning

confidence: 99%

“…5,6 The European Medicines Agency granted a marketing authorization, valid throughout the European Union, for parecoxib sodium in March 2002. 7 It is usually given in an initial dose of 40 mg, followed by further doses of 20 mg or 40 mg as required every 6 to 12 hours, with a maximum dose of 80 mg a day.…”

Section: Introductionmentioning

confidence: 99%

Daily Subcutaneous Parecoxib Injection for Cancer Pain: An Open Label Pilot Study

Kenner

Bhagat

Fullerton

2015

Journal of Palliative Medicine

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show abstract

“…22,35,36 Non-steroidal-antinflammatory drugs (NSAID) should also play a role in a complete multimodal framework, when not contraindicated. There is clinical evidence for some molecules: ibuprofen (associated with oxycodone, caffeine or acetaminophen, [37][38][39] etodolac, 40 ketoprofen and dexketoprofen, 41 lumiracoxib and parecoxib, 42,43 mefenamic acid, 44 naproxen, 45 piroxicam, 46 lornoxicam, 47 acetaminophen (alone or codeine-associated). 48,49 …”

Section: Reviewmentioning

confidence: 99%

Anesthetics considerations in peritonitis

et al. 2017

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Peritonitis remains an illness with a significant mortality rate in surgery. Age, male sex, and the inability to control the source are associated with greater mortality. Anesthesia and perioperative medicine should aim to stop the increase in metabolic debt in the pre-surgical phase and to provide metabolic steering during surgery. Early goal directed therapy (EGDT) is still the mandatory cornerstone of management, presented here in several different versions, depending on the monitoring system available in the local clinical environment. The discharge from the operating room to a proper clinical setting must be based on a suitable scoring system, such as APACHE II (acute physiology and chronic health evaluation). Clinical surveillance, when the patient is on the ward, has to be governed for a period using a nursing score like the modified early warning score. Antimicrobial therapy, as well as appropriate timing of administration is both important. Analgesia, locoregional whenever possible, is also an important tool for preventing complications, which occur mainly during the postoperative period, and most frequently in the first month.

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“…Beberapa penelitian menyatakan bahwa dosis 20-40 mg parecoxib dapat memberikan efek analgetika terhadap 50-60% pasien dengan nyeri akut pascaoperasi derajat sedang hingga berat, namun tidak mengganggu fungsi platelet dan mukosa gastrointestinal. [5][6][7][8] Parasetamol memiliki efek analgesik yang bersifat sentral dan aktivitas penghambatan produksi prostaglandin melalui penghambatan aktivitas COX-2 yang setara dengan NSAID. Kemampuan parasetamol dalam menghambat enzim cyclooxygenase-1 (COX-1) lebih rendah dibanding dengan NSAID.…”

Section: -4unclassified

Perbandingan Efek Pemberian Analgesia Pre-emtif Parecoxib dengan Parasetamol terhadap Nyeri Pascaoperasi Radikal Mastektomi Menggunakan Numeric Rating Scale

Kartapraja¹,

Fuadi²,

Redjeki³

2016

jap

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AbstrakMastektomi merupakan prosedur operasi pengangkatan kanker payudara yang dapat menimbulkan nyeri akut pascaoperasi, bahkan pada 20-30% pasien berlanjut menjadi sindrom nyeri kronik pascamastektomi sehingga diperlukan penatalaksanaan nyeri secara adekuat agar pasien tidak mengalami episode nyeri yang dapat mengganggu produktivitas. Tujuan penelitian ini membandingkan efek pemberian analgesia pre-emtif parecoxib dengan parasetamol dalam menurunkan nyeri pascaoperasi radikal mastektomi. Penelitian dilakukan secara prospektif single blind randomized controlled trial terhadap 30 pasien dewasa yang menjalani operasi radikal mastektomi di Rumah Sakit Dr. Hasan Sadikin Bandung periode SeptemberNovember 2014. Subjek dibagi dalam dua kelompok, analgesia pre-emtif parasetamol 1 g dan parecoxib 40 mg diberikan 30 menit sebelum sayatan pertama dilakukan. Setelah operasi selesai dicatat skala nyeri berdasarkan numeric rating scale (NRS) hingga 12 jam pascaoperasi di ruang perawatan. Analisis data menggunakan uji-t dan diolah dengan program statistical package for social science (SPSS) versi 21.0 for windows. Kelompok analgesia pre-emtif parecoxib 40 mg lebih lama membutuhkan analgetik pertolongan dan menurunkan NRS lebih rendah dibanding dengan kelompok analgesia preemtif parasetamol 1 g (p<0,05). Simpulan, parecoxib 40 mg lebih baik dibanding dengan analgesia pre-emtif parasetamol 1 g dalam menurunkan nyeri pascaoperasi radikal mastektomi berdasarkan NRS.Kata kunci: Analgesia pre-emtif, numeric rating scale, nyeri pascaoperasi, parasetamol, parecoxib, radikal mastektomi Comparative Effect of Preemptive Analgesia Parecoxib with Paracetamol against Postoperative Radical Mastectomy Pain Using Numeric Rating Scale AbstractMastectomy is a breast cancer surgery procedure that can lead to acute postoperative pain with 20-30% of patients may progress to postmastectomy chronic pain syndrome (PMPS). Therefore, it is necessary provide an adequate pain management so patients will not experience episodes of pain that can disrupt their productivity. The purpose of this study was to compare the effect of preemptive analgesia parecoxib with paracetamol in reducing radical mastectomy postoperative pain.The study was a prospective single blinded randomized controlled clinical trials on 30 adult patients who underwent radical mastectomy surgery in Dr. Hasan Sadikin General Hospital between September and November 2014. Subjects were divided randomly into two groups, 1 gram paracetamol preemptive analgesia and 40 miligram parecoxib which given 30 minutes before the first incision has been made. After the surgery was completed, we record the pain scale using the numeric rating scale (NRS). The data were recorded starting from the recovery room to 12 hours postoperative in the ward. Statistical analysis was performed using the t-test with statistical package for social science (SPSS) version 21.0 for Windows software. The results showed that the 40 miligram parecoxib preemptive analgesia group required longer rescue analgesics and lowerNRS t...

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Intravenous or intramuscular parecoxib for acute postoperative pain in adults

Cited by 75 publications

References 65 publications

Daily Subcutaneous Parecoxib Injection for Cancer Pain: An Open Label Pilot Study

Daily Subcutaneous Parecoxib Injection for Cancer Pain: An Open Label Pilot Study

Anesthetics considerations in peritonitis

Perbandingan Efek Pemberian Analgesia Pre-emtif Parecoxib dengan Parasetamol terhadap Nyeri Pascaoperasi Radikal Mastektomi Menggunakan Numeric Rating Scale

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