Intravenous paracetamol vs ibuprofen in renal colic: a randomised, double-blind, controlled clinical trial

Cenker, E.; Serinken, Mustafa; Uyanık, Emrah

doi:10.1007/s00240-017-0997-7

Cited by 9 publications

(19 citation statements)

References 15 publications

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“…More rapid effect of ibuprofen compared with paracetamol has also been confirmed in Cenker et al study (15). Imani et al have also suggested that combining a lower than usual dose of ketorolac with dexmedetomidine can also be effective in post-caesarean pain management (17).…”

Section: Discussionsupporting

confidence: 59%

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Comparison of Intravenous Ibuprofen with Intravenous Ketorolac in Renal Colic Pain Management; A Clinical Trial

et al. 2019

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BackgroundChoosing a proper medication for pain management of patients with acute renal colic has been a challenge for physicians treating these patients.ObjectivesThe present study was performed with the aim of comparing intravenous (IV) ibuprofen and IV ketorolac in pain management of these patients.MethodsIn the present double-blind clinical trial study, patients suspected with renal colic presented to the emergency department were randomly divided into 2 groups receiving IV ibuprofen or IV ketorolac and were compared regarding effectiveness (pain reduction 15, 30, and 60 minutes after injection), treatment success, and possible side effects.ResultsIn total, 240 patients suspected with renal colic with the mean age of 27.38 ± 12.32 years were randomly divided into 2 groups of 120 individuals treated with IV ketorolac or ibuprofen (66.4% male). The two groups were in a similar condition regarding age (P = 0.56), sex (P = 0.78) history of kidney stone (P = 0.40), vital signs (P > 0.05), stone size (P = 0.73), stone location (P = 0.13), and pain severity on admission (P = 0.32). 15, 30, and 60 minutes after drug injection, pain severity in the ketorolac group was significantly higher than the group receiving ibuprofen (P < 0.0001 for all comparisons), yet these differences were not clinically significant. Fifteen minutes after the injection, the rate of treatment success was significantly higher in the group receiving IV ibuprofen (P < 0.0001). After 60 minutes, the number of completely relieved cases reached 37 (30.8%) patients in the ketorolac group and 83 (69.1%) patients in the ibuprofen group. No significant difference was seen in side effects between the two groups (P = 0.35).ConclusionsThe findings of the present study show that ibuprofen is a more rapid acting drug compared to ketorolac in controlling pain caused by renal colic. In addition, its rate of complete relief from pain was twice as much as that of ketorolac. Since the side effects observed for ibuprofen in the present study were very mild, it is suggested to use this drug in treatment and pain control of renal colic patients.

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Section: Discussionsupporting

confidence: 59%

“…The sample size was estimated as 50 people in each group considering the decrease of 3 points on VAS as clinically significant, standard deviation of ketorolac and ibuprofen effectiveness in reducing migraine pain on VAS were 2.88 and 1.44 (15, 16), α = 0.05, and β = 0.1. The data were analyzed using SPSS version 21.…”

Section: Methodsmentioning

confidence: 99%

Comparison of Intravenous Ibuprofen with Intravenous Ketorolac in Renal Colic Pain Management; A Clinical Trial

et al. 2019

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“…[ 12 ] Besides, some previous research has made comparative evaluation of these two drugs, especially in the treatment of pain. [ 13 14 ] In this regard, our study is a first in the literature comparing the effectiveness of IV paracetamol and ibuprofen on fever management in adult patients in ED. It should also be noted that the two patient groups in our study did not differ in sociodemographic data and clinical scores as well as in laboratory parameters.…”

Section: Discussionmentioning

confidence: 99%

Comparative evaluation of the efficacy of intravenous paracetamol and ibuprofen on the treatment of tonsillopharyngitis with fever

Oncel

Yılmaz

Sabırlı

et al. 2021

Turkish Journal of Emergency Medicine

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OBJECTIVE: Tonsillopharyngitis is one of the constituents of upper respiratory tract infection (URTI). Fever is a URTI symptom requiring treatment due to the occurrence of discomfort and high fever-based complications. This study primarily sets out to observe and compare the efficacy of intravenous administration of paracetamol and ibuprofen drugs on fever in adult patients with tonsillopharyngitis. METHODS: This study was performed in a prospective, randomized controlled, double-blind design. The study population was divided as Group 1 (treated with paracetamol) and as Group 2 (treated with ibuprofen). While the first group was treated with paracetamol as 1000 mg in 150 ml normal saline, the second group was treated with ibuprofen as 400 mg in 150 ml normal saline. The primary outcome was the decrease in fever at 15, 30, and 60 min, while the secondary outcome was the need for additional treatment after 60 min. RESULTS: One hundred and eighty-five patients were included in the final analysis. The mean age of the paracetamol group (57.4% male) was 28.36 ± 9.6, whereas that of the ibuprofen group (54.9% male) was 27.45 ± 7.98. Fever was reduced significantly between 0 and 60 min in both groups (P ≤ 0.001 and P ≤ 0.001, respectively). Although the antipyretic effect of ibuprofen was more pronounced in the early period than that of paracetamol, no significant difference was noted between the two groups in terms of fever drop between 0 and 60 min (P = 0.350). CONCLUSION: Although both drugs prove effective in controlling fever at the 60 min, stronger efficacy of ibuprofen in the first 15 min may enable rapid discharge from the emergency department.

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“…24 IV ibuprofen (800 mg) is more effective than IV paracetamol (1 g) in reducing renal colic pain. 25 To the best of our knowledge, a study that compared analgesic effects of IV ibuprofen and paracetamol in repeated doses after laparoscopic cholecystectomy has not yet been reported.…”

Section: Discussionmentioning

confidence: 99%

Comparison of Analgesic Effects of Paracetamol and Ibuprofen After Laparoscopic Cholecystectomy

Demiroluk¹,

Abitağaoğlu²,

Göçmen³

et al. 2019

Turkiye Klinikleri J Med Sci

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Intravenous paracetamol vs ibuprofen in renal colic: a randomised, double-blind, controlled clinical trial

Cited by 9 publications

References 15 publications

Comparison of Intravenous Ibuprofen with Intravenous Ketorolac in Renal Colic Pain Management; A Clinical Trial

Comparison of Intravenous Ibuprofen with Intravenous Ketorolac in Renal Colic Pain Management; A Clinical Trial

Comparative evaluation of the efficacy of intravenous paracetamol and ibuprofen on the treatment of tonsillopharyngitis with fever

Comparison of Analgesic Effects of Paracetamol and Ibuprofen After Laparoscopic Cholecystectomy

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