Intravenous Pentamidine-Induced Bronchospasm

Gearhart, Maureen O.; Bhutani, Manoop S.

doi:10.1378/chest.102.6.1891

Cited by 8 publications

(1 citation statement)

References 11 publications

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“…One case of drug-induced pneumonitis was documentedin this study; as far as weare aware this is the first reported case. Systemic side effects caused by parenteral pentamidine have also been reported; sometimesthe side effects are severe but rarely life threatening, and include hypoglycemia (7), bronchospasm (8), and bradycardia (9). In this study, 46.…”

Section: Discussionmentioning

confidence: 99%

Complications During Clinical Courses of Pneumocystis Carinii Pneumonia in Patients with Acquired Immunodeficiency Syndrome.

et al. 2001

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Objective To describe the incidence of complications before and during therapy of Pneumocystis carinii pneumonia (PCP) in patients with acquired immunodeficiency syndrome (AIDS).Methods A retrospective review of the patient's medical records.Patients A total of29 patients with AIDS and PCP who were admitted to the AIDS Clinical Center, International Medical Center of Japan from July 1996 to November 1999. Results Adverse effects were found in 24 (88.9%) of 27 patients treated with trimethoprim/sulfamethoxazole (T/S), 6 (46.1 %) of 13 treated with parenteral pentamidine, and 2 (20 %) of 10 treated with inhaled pentamidine. Infectious and/or non-infectious complications were found in 25 (86.2 % ) of 29 study patients. Regarding infectious complications, 16 (55.2%) were found on admission and 10 cases (34.5 %) with infectious complications were identified during admission; including oral candidiasis (37.9% and 17.2%, respectively) and genital herpes (3.4% and 6.9%, respectively). Cytomegalovirusantigenemia was detected in 4 cases (13.8%) on admission and 12 cases (41.4%) during admission. Non-infectious complications affected ll cases (37.9%) on admission, and 6 cases (20.7%) during admission, the latter included heart failure (10.3%) and pneumothorax (6.9%). PCPwas successfully treated in all but one patient who suffered from repeated pneumothorax.Conclusion Treatment of PCPcan be problematic and it is important to be aware of the high incidence of various complications that can occur during the treatment of PCP. (Internal Medicine 40: 221-226, 2001)

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Section: Discussionmentioning

confidence: 99%

Complications During Clinical Courses of Pneumocystis Carinii Pneumonia in Patients with Acquired Immunodeficiency Syndrome.

et al. 2001

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Advances in the Treatment and Prophylaxis ofPneumocystis cariniiPneumonia

Warren,

George,

You

et al. 1997

Pharmacotherapy

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Pneumocystis carinii pneumonia (PCP) is the most common illness associated with the acquired immunodeficiency syndrome (AIDS) in the United States and also occurs in immunocompromised persons not infected with the human immunodeficiency virus. Several advances have taken place in the treatment and prophylaxis of PCP, with most clinical trials conducted in patients with AIDS. Treatment of choice is trimethoprim‐sulfamethoxazole (TMP‐SMX). Desensitization regimens are available for those who have a fever or rash associated with the agent. Patients with severe PCP who cannot tolerate TMP‐SMX may be treated successfully with pentamidine or trimetrexate. Those with mild to moderate disease may receive dapsone‐trimethoprim, clindamycin‐primaquine, or atovaquone if they cannot take TMP‐SMX. Adjunctive therapy with corticosteroids improves the outcome in patients with AIDS and severe PCP. (Pharmacotherapy 1997;17(5):900–916)

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Drug-induced pulmonary disease

Rosenow

1994

Disease-a-Month

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Intravenous Pentamidine-Induced Bronchospasm

Cited by 8 publications

References 11 publications

Complications During Clinical Courses of Pneumocystis Carinii Pneumonia in Patients with Acquired Immunodeficiency Syndrome.

Complications During Clinical Courses of Pneumocystis Carinii Pneumonia in Patients with Acquired Immunodeficiency Syndrome.

Advances in the Treatment and Prophylaxis ofPneumocystis cariniiPneumonia

Drug-induced pulmonary disease

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