Intravenous Prostaglandin E1 in Severe Peripheral Vascular Disease

Carlson, L. A.; Olsson, A G

doi:10.1016/s0140-6736(76)90653-x

Cited by 147 publications

(31 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This vasodilating action has therapeutic potential. For example, beneficial effects of PGI2 have been demonstrated in patients with pulmonary hypertension (11)(12)(13)(14), peripheral ischemic vascular disease (15)(16)(17)(18)(19), and unstable angina (20). Furthermore, the increase in tissue conductance, which is the reciprocal ofvascular resistance, particularly in the splanchnic circulation, coupled with the augmentation of cardiac output, which has been established experimentally, provides rationale for the use of PGI2 in the management of congestive heart failure (21).…”

Section: Introductionmentioning

confidence: 99%

Effect of prostacyclin on vascular capacity in the dog.

Fulghum¹,

DiMarco²,

Supple³

et al. 1985

J. Clin. Invest.

View full text Add to dashboard Cite

show abstract

Section: Introductionmentioning

confidence: 99%

Effect of prostacyclin on vascular capacity in the dog.

Fulghum¹,

DiMarco²,

Supple³

et al. 1985

J. Clin. Invest.

View full text Add to dashboard Cite

show abstract

“…In healthy individuals, forearm blood How was improved [7] while in subjects with peri pheral vascular disease, PGE, infusion proved beneficial [8] and was associated with accelerated healing of leg ulcers [9], As a preoperative treatment for subjects with obstructive lesions of the systemic circulation, PGE| in fusion was found to reduce early surgical mortality [10]. Dowd et al…”

Section: Renal Disease Polyunsaturated Fatty Acids and Blood Rheologymentioning

confidence: 99%

Renal Disease, Polyunsaturated Fatty Acids and Blood Rheology

Simpson¹

1986

Nephron

View full text Add to dashboard Cite

“…Prostaglandin E1 (PGE1) is known to be a powerful vasodilator, 4 and has been established as an effective therapeutic agent for the treatment of peripheral vascular diseases by enhancing blood supply. Recently, its effect on peripheral nerve diseases has been highlighted.…”

Section: Introductionmentioning

confidence: 99%

Prostaglandin E1 analog increases spinal cord blood flow at the point of compression during and after experimental spinal cord injury

et al. 2009

View full text Add to dashboard Cite

Study design: An in vivo study using a spinal cord compression model in rats. Objectives: To evaluate the effect of prostaglandin E1 (PGE1) on the change in thoracic spinal cord blood flow and on hind-limb motor function. Background: Until now, effect of PGE1 on spinal cord blood flow at the point of compression has not been tested. Methods: Our newly developed blood flow measurement system was a combination of a noncontacttype Laser Doppler system and a spinal cord compression device. The rat thoracic spinal cord was exposed and spinal cord blood flow at the point of compression was measured before, during and after compression. The functioning of the animals' hind-limbs was evaluated by the BBB Scale and by measuring the frequency of voluntary standing. Results: During the compression period, spinal cord blood flow was significantly higher in the PGE1-treated rats than in the control rats, which did not receive PGE1. After decompression, the spinal cord blood flow rapidly recovered to about 60% of the precompression level in the control rats. When the animals were treated with PGE1, blood flow after decompression reached about 90% of the precompression level. Twenty-gram compression for 40 mins induced motor deficiencies in the rat hind-limbs. The application of PGE1 significantly improved motor function of the rat hind-limbs after spinal cord injury. Conclusions: The application of PGE1 increased spinal cord blood flow during and after spinal cord compression, and improved motor function after the spinal cord injury.

show abstract

Intravenous Prostaglandin E1 in Severe Peripheral Vascular Disease

Cited by 147 publications

References 0 publications

Effect of prostacyclin on vascular capacity in the dog.

Effect of prostacyclin on vascular capacity in the dog.

Renal Disease, Polyunsaturated Fatty Acids and Blood Rheology

Prostaglandin E1 analog increases spinal cord blood flow at the point of compression during and after experimental spinal cord injury

Contact Info

Product

Resources

About