2018
DOI: 10.1002/clc.23052
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Intravenous regadenoson with aminophylline reversal is safe and equivalent to intravenous adenosine infusion for fractional flow reserve measurements

Abstract: For FFR measurement, regadenoson and adenosine are equivalent hyperemic agents. Regadenoson with aminophylline reversal may be considered as an alternative to adenosine for FFR measurements.

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Cited by 3 publications
(5 citation statements)
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“…There was no evidence of dissemination bias on visual inspection of the funnel plot and Begg’s test. There were no adverse effects reported in either arm of the study by Edward et al [ 14 ] among forty-six participants in the analysis where aminophylline were administered after regadenoson, while side effects reported in other studies were only transient and did not necessitate discontinuation of infusion or FFR measurement. In the study by Arumugham et al [ 11 ], a higher dose of IV adenosine was infused, while significant adverse event rates were not higher.…”
Section: Resultsmentioning
confidence: 86%
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“…There was no evidence of dissemination bias on visual inspection of the funnel plot and Begg’s test. There were no adverse effects reported in either arm of the study by Edward et al [ 14 ] among forty-six participants in the analysis where aminophylline were administered after regadenoson, while side effects reported in other studies were only transient and did not necessitate discontinuation of infusion or FFR measurement. In the study by Arumugham et al [ 11 ], a higher dose of IV adenosine was infused, while significant adverse event rates were not higher.…”
Section: Resultsmentioning
confidence: 86%
“…Mean difference in measured FFR values with adenosine and regadenoson in pooled analysis was -0.00 [95%CI: (-0.02)-0.01; P = 0.88], with I 2 estimate for heterogeneity 0%. An exclusionary sensitivity analysis was performed with exclusion of studies with lesions including low- and high-grade stenosis (Van Nunen et al [ 13 ] and Edward et al [ 14 ]), where results remained consistent with mean difference -0.00 [(-0.03)-0.02; P = 0.92] (Figure 2B ). Time to achieve FFR was reported in three of five studies, and was significantly lower with regadenoson with a mean difference of 34.31 s (95%CI: 25.14-43.48 s; P < 0.01) (Figure 3A ).…”
Section: Resultsmentioning
confidence: 90%
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