Intravenous secretin for autism spectrum disorders (ASD)

Williams, Katrina; Wray, John J; Wheeler, Danielle M

doi:10.1002/14651858.cd003495.pub3

Cited by 60 publications

(29 citation statements)

References 41 publications

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“…In addition to the NICE guideline, nine systematic reviews , and 10 Cochrane reviews were relevant to impaired social communication as a treatment target in ASD.…”

Section: Results and Clinical Practice Recommendationsmentioning

confidence: 99%

“…Meta‐analysis was not possible due to differences in outcome measures used . Finally, with respect to biomedical interventions, Cochrane reviews on gluten/casein‐free diets , secretin , chelation , hyperbaric oxygen therapy , omega‐3 fatty acids reinforce the NICE guideline's conclusions of not recommending any of these interventions for the treatment of core ASD deficits, including impaired social interaction and communication. In addition to lack of evidence of any benefit with treatment, Cochrane reviews highlight concerns regarding serious adverse events with chelation (e.g.…”

Section: Results and Clinical Practice Recommendationsmentioning

confidence: 99%

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Systematic review and guide to management of core and psychiatric symptoms in youth with autism

Ameis

Kassee

Corbett-Dick

et al. 2018

Acta Psychiatr Scand

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“…In addition to the NICE guideline, nine systematic reviews , and 10 Cochrane reviews were relevant to impaired social communication as a treatment target in ASD.…”

Section: Results and Clinical Practice Recommendationsmentioning

confidence: 99%

Section: Results and Clinical Practice Recommendationsmentioning

confidence: 99%

Systematic review and guide to management of core and psychiatric symptoms in youth with autism

Ameis

Kassee

Corbett-Dick

et al. 2018

Acta Psychiatr Scand

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“…Thus, we included 17 systematic reviews. 4,[10][11][12][13][14][15][16][17][18][19][20][21][22][23][24][25] Results from systematic reviews A summary of each systematic review is presented narratively below. In addition, Table 2 4,10-25 presents the issues addressed, the main findings from each systematic review and the quality of the evidence (based on the GRADE approach).…”

Section: Search Resultsmentioning

confidence: 99%

What do Cochrane systematic reviews say about interventions for autism spectrum disorders?

et al. 2017

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CONTEXT AND OBJECTIVE: Autism spectrum disorders (ASDs) include autistic disorder, Asperger's disorder and pervasive developmental disorder. The manifestations of ASDs can have an important impact on learning and social functioning that may persist during adulthood. The aim here was to summarize the evidence from Cochrane systematic reviews on interventions for ASDs. DESIGN AND SETTING: Review of systematic reviews, conducted within the Discipline of Evidence-Based Medicine, Escola Paulista de Medicina, Universidade Federal de São Paulo. METHODS:We included and summarized the results from Cochrane systematic reviews on interventions for ASDs. RESULTS: Seventeen reviews were included. These found weak evidence of benefits from acupuncture, gluten and casein-free diets, early intensive behavioral interventions, music therapy, parent-mediated early interventions, social skill groups, Theory of Mind cognitive model, aripiprazole, risperidone, tricyclic antidepressants and selective serotonin reuptake inhibitors (SSRI); this last only for adults. No benefits were found for sound therapies, chelating agents, hyperbaric oxygen therapy, omega-3, secretin, vitamin B6/ magnesium and SSRI for children. CONCLUSION: Acupuncture, gluten and casein-free diets, early intensive behavioral interventions, music therapy, parent-mediated early interventions, social skill groups and the Theory of Mind cognitive model seem to have benefits for patients with autism spectrum disorders (very low to low-quality evidence). Aripiprazole, risperidone, tricyclic antidepressants and SSRI (this last only for adults) also showed some benefits, although associated with higher risk of adverse events. Experimental studies to confirm a link between probable therapies and the disease, and then high-quality long-term clinical trials, are needed. RESUMO MÉTODOS:Nós incluímos e resumimos os resultados de revisões sistemáticas Cochrane sobre intervenções para TEA. RESULTADOS: Foram incluídas 17 revisões que encontraram evidências fracas de benefícios da acupuntura, dietas isentas de glúten e caseína, intervenção comportamental intensiva precoce, musicoterapia, intervenção precoce mediada pelos pais, grupos de habilidades sociais, modelo cognitivo de Teoria da Mente, aripiprazol, risperidona, antidepressivos tricíclicos, inibidores seletivos da recaptação da serotonina (ISRS); o último apenas para adultos. Nenhum benefício foi encontrado com terapias sonoras, agentes quelantes, oxigenoterapia hiperbárica, ômega-3, secretina, vitamina B6/magnésio e ISRS para crianças. CONCLUSÃO: Acupuntura, dietas sem glúten e caseína, intervenção comportamental intensiva precoce, musicoterapia, intervenção precoce mediada pelos pais, grupos de habilidades sociais e modelo cognitivo de Teoria da Mente parecem ter benefícios para pacientes com TEA (evidência de qualidade muito baixa a baixa). Aripiprazol, risperidona, antidepressivos tricíclicos e ISRS (o último apenas para adultos) também apresentam algum benefício, embora estejam associados a maior risco de event...

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“…Similarly, there is no of evidence supporting the benefits of hyperbaric oxygen therapy, and again this also has potentially serious adverse effects (Xiong et al, 2016). No evidence of benefits are found for secretin (Williams et al, 2012). Tables Table 1 …”

Section: Panel 4 Current Evidence Of Other Interventionsmentioning

confidence: 99%

Evidence-based support for autistic people across the lifespan: Maximizing potential, minimizing barriers, and optimizing the person-environment fit

Lai¹,

Anagnostou²,

Wiznitzer³

et al. 2018

Preprint

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Autism is both a medical condition that can give rise to disability and an example of human neurological variation ('neurodiversity') that contributes to identity, with cognitive assets and challenges. We refer to this as the dual nature of autism. Enhancing adaptation and wellbeing is the ultimate goal for intervention/support. Evidence-based support for autistic people across the lifespan is emerging. Support should be collaborative between autistic individuals, their families, and service providers, taking a shared decision-making approach. To maximize the individual's potential, comprehensive early intervention and parent-mediated intervention, ideally taking a naturalistic approach, may help support the early development of adaptive, cognitive and language skills. Key words: autism, support, intervention, treatment, adaptation, development, lifespan, health, disability, neurodiversity OSF preprint first posted online July 19, 2018; https://dx.doi.org/10.31219/osf.io/8z5rv The copyright holders for this preprint (which was not peer-reviewed) are the authors Lai et al. (2018) Evidence-based support for autistic people across the lifespan 3The duality of autism Autism spectrum disorder/conditions (ASD or ASC (Lai and Baron-Cohen, 2015), henceforth 'autism') are atypical neurodevelopmental conditions that emerge early in life (Varcin and Jeste, 2017), with strong genetic aetiologies (Tick et al., 2016) shaped by subsequent gene-environmental interplays (Mandy and Lai, 2016). Autism has lifespan impact on an individual's development and adaptation (Howlin and Magiati, 2017). As a result of evolving diagnostic concepts, recognition of the spectrum and its multi-subgroup nature (Lai et al., 2013), along with increased awareness (Liu et al., 2010), autismformerly regarded as rare -is now considered relatively common. Globally, close to 1% of the population has a formal autism diagnosis (Baxter et al., 2015). In developed countries the prevalence is close to 1·5% (Lyall et al., 2017), with a male:female ratio of 3-4:1 (Loomes et al., 2017).Characteristics associated with autism (ie, 'autistic traits') fall along a spectrum in the general population across dimensions of social-communication, repetitive and stereotyped behaviours, and other non-clinical and cognitive features (Constantino et al., 2010, Ruzich et al., 2015, Skuse et al., 2009. Elevated autistic traits are particularly common in family members of people who have an autism diagnosis (Pickles et al., 2000, Piven et al., 1997, Wheelwright et al., 2010. Both clinical autism and the dimensional traits are associated with the additive effect of common and rare genetic variations (Geschwind and State, 2015, Robinson et al., 2016, Weiner et al., 2017, although their exact causal roles remain unclear.The dimensional nature of autistic traits makes it challenging to draw a clear diagnostic line, especially when genetic or other diagnostic biomarkers are not yet available (Constantino and Charman, 2016). From a medical perspective, a clinical diagnosi...

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Intravenous secretin for autism spectrum disorders (ASD)

Abstract: Freeman 1986 Freeman BJ, Ritvo ER, Yokota A, Ritvo A. A scale for rating symptoms of patients with the syndrome of autism in real life settings.

Cited by 60 publications

References 41 publications

Systematic review and guide to management of core and psychiatric symptoms in youth with autism

Systematic review and guide to management of core and psychiatric symptoms in youth with autism

What do Cochrane systematic reviews say about interventions for autism spectrum disorders?

Evidence-based support for autistic people across the lifespan: Maximizing potential, minimizing barriers, and optimizing the person-environment fit

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