Intravenous sodium lactate decreases plasma GABA levels in man

Balon, Richard; Petty, Frederick; Yeragani, Vikram K.; Kramer, Gerald L.; Pohl, Robert

doi:10.1007/bf02251295

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Valproate1

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1993

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Cited by 7 publications

(1 citation statement)

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“…Interestingly. Balon et al [34] recently reported that intravenous infusion of lactate pro duced a decrease in circulating plasma GABA concentra tions which are thought to reliably reflect changes in cen tral GABA metabolism. Thus, it is possible that valproate may prevent lactate induction of panic attacks by its GABAergic activity.…”

Section: Valproatementioning

confidence: 99%

Antiepileptic Drugs for the Treatment of Panic Disorder

et al. 1993

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Evidence from preclinical studies, preliminary clinical reports, pharmacologic challenge studies and a small number of controlled trials suggests that several antiepileptic agents – valproate, carbamazepine, and clonazepam – may have therapeutic effects in the treatment of patients with panic disorder. We review the theoretical basis and available clinical data supporting the use of these agents in panic disorder.

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Section: Valproatementioning

confidence: 99%