Intraventricular and meningeal anaplastic meningiomas in a heifer

Ohfuji, S.

doi:10.1007/s00580-013-1724-6

Cited by 2 publications

(1 citation statement)

References 13 publications

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“…47 However, benign meningiomas, diagnosed only in 20% of the cases in this report, occurred less frequently than has been reported in humans (80%) 39 and in dogs (around 50%). 47 Infrequent cases of meningioma have been described in cattle, 1,13,17,30,48 and apart from an anaplastic meningioma, 48 none of the meningeal subtypes encountered here have been reported before. The majority has been described as the fibroblastic subtype and a link with bovine papillomavirus infection has been shown experimentally.…”

Section: Discussionmentioning

confidence: 64%

Bovine intracranial neoplasia: A retrospective case series

Jahns

McElroy²

2022

Vet Pathol

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This case series describes the clinical and pathological findings of intracranial neoplasms in cattle, a rare entity. Data and archived tissues from 24 intracranial tumors were reviewed and investigated by immunohistochemistry for S100, glial fibrillary acidic protein, synaptophysin, pancytokeratin, vimentin, neuron-specific enolase, oligodendrocyte transcription factor 2, and isocitrate dehydrogenase 1. Ages of affected cattle ranged from 6 months to 14 years (5.7 ± 3.6 years; mean ± SD). Predominant clinical signs were altered mental state, central vestibular dysfunction, and cerebellar incoordination. Twelve gliomas, all high grade, were the most common tumors observed: oligodendrogliomas (n = 6), astrocytomas (n = 4), and undefined gliomas (n = 2). The oligodendrogliomas were located in the brainstem and extended into the ventricles, whereas all astrocytomas were located in the forebrain. Isocitrate dehydrogenase 1 gene mutation as described in humans was not detected. The 5 meningiomas exhibited microcystic, chordoid, atypical, papillary, and anaplastic subtypes. Metastatic carcinomas (n = 4) were the only secondary tumor type present, and these were located at the level of the medulla with infiltration of cranial nerves and in one case leptomeningeal carcinomatosis. In addition, 2 medulloblastomas and 1 choroid plexus carcinoma were diagnosed. Immunohistochemistry for vimentin and pancytokeratin was particularly useful to distinguish meningiomas and choroid plexus carcinoma (positive for vimentin only) from mestastatic carcinomas (positive for cytokeratin only) as all showed a papillary growth pattern. Overall, the morphological features were comparable with other species and the human and canine classifications could be applied.

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