Intraventricular antibiotics for bacterial meningitis in neonates

Shah, Sachin S; Ohlsson, Arne; Shah, Vibhuti

doi:10.1002/14651858.cd004496

Cited by 13 publications

(19 citation statements)

References 23 publications

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“…There are reported cases of successful treatment of MRAB neonatal ventriculitis with intravenous and intraventricular colistin [10][11][12]. A recent cochrane review shows that intraventricular treatment of neonatal ventriculitis is associated with three folds increase in the mortality as compared to receiving intravenous antibiotics alone thus advocating the avoidance of this modality [13].…”

Section: Discussionmentioning

confidence: 99%

Neonatal Ventriculitis with Multi Drug Resistant Acinetobactor baumanii: A Case Report and Review of Literature

Mehar¹,

Zade²,

Joshi³

et al. 2012

Pediat Therapeut

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Meningitis due to Multi Drug Resistant Acinetobacter baumannii (MRAB) is a serious emerging problem in pediatric intensive care. Treatment of these patients is challenging and polypeptide antibiotic is an important option but have poor cerebrospinal fluid (CSF) penetration. We describe our experience of a successfully treated neonatal ventriculitis and meningitis due to MRAB with intraventricular polymyxin B.

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Section: Discussionmentioning

confidence: 99%

Neonatal Ventriculitis with Multi Drug Resistant Acinetobactor baumanii: A Case Report and Review of Literature

Mehar¹,

Zade²,

Joshi³

et al. 2012

Pediat Therapeut

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“…The recommended antimicrobial treatment based on causative organism and dosage of common antibiotics used for neonatal meningitis are provided in Tables 3 and 4 [4,50,87,97,103,104].…”

Section: Antimicrobial Treatmentmentioning

confidence: 99%

Neonatal Bacterial Meningitis

Ipek¹

2019

Neonatal Medicine

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Despite improvements in neonatal intensive care, neonatal bacterial meningitis continues to be a serious disease with mortality rates varying between 10 and 15%. Additionally, long-term complications are observed among 20-50% of survivors, depending on time of diagnosis and therapy and virulence of the infecting pathogen. It is more common during the neonatal period than at any other age with the estimated incidence of 0.25 per 1000 live births. The absence of specific clinical presentation makes diagnosis of meningitis more difficult in neonates than in older children. Culture of cerebrospinal fluid is the traditional gold standard for diagnosis of bacterial meningitis, so all newborn infants with proven or suspected sepsis should undergo lumbar puncture. However, deciding when to perform lumbar puncture and interpretation of the results are challenging. Although the pathophysiology of neonatal meningitis is complex and not fully understood, researches on diagnostic and prognostic tools are ongoing. Prevention of neonatal sepsis, early recognition of infants at risk, development of novel, rapid diagnostics and adjunctive therapies, and appropriate and aggressive antimicrobial treatment to sterilize cerebrospinal fluid as soon as possible may prevent the lifelong squeal of bacterial meningitis in newborn infants.

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“…Esto sumado a la carencia de evidencia para su uso de primera línea, limita esta terapia a casos concretos en los cuales no se ha obtenido una respuesta satisfactoria (clínica y paraclínica) a la terapia sistémica de acuerdo al criterio médico (121)(122)(123)(124)(125) . Además, de acuerdo a la evidencia disponible, esta terapia está contraindicada en neonatos, dado que una revisión de Cochrane encontró una mayor mortalidad asociada a la administración intratecal/intraventricular de antimicrobianos en esta población (126) . Dentro de las intervenciones de prevención, existe un estudio de casos y controles que usa vancomicina de modo preventivo para la reducción de ISO, cuando se dejan drenajes ventriculares externos con resultados favorables, pero que requieren de estudios prospectivos con mayor poder estadístico (127) .…”

Section: Antibióticos Intratecales/ Intraventricularesunclassified

Prevención y tratamiento de las infecciones del sitio operatorio en neurocirugía. Estado del arte

García-Casallas

Blanco-Mejía²,

Fuentes

et al. 2019

Iatreia

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El manejo adecuado de las infecciones del sitio operatorio (ISO) en neurocirugía es fundamental para la disminución de la carga de morbilidad y mortalidad en estos pacientes.La sospecha y confirmación diagnóstica asociadas al aislamiento microbiológico son esenciales para asegurar el tratamiento oportuno y el adecuado gerenciamiento de antibióticos. En esta revisión se presenta de forma resumida los puntos fundamentales para la prevención y el tratamiento de infecciones del sitio operatorio en neurocirugía y se incluye un apartado sobre el uso de antibióticos intratecales/intraventriculares.

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Intraventricular antibiotics for bacterial meningitis in neonates

Cited by 13 publications

References 23 publications

Neonatal Ventriculitis with Multi Drug Resistant Acinetobactor baumanii: A Case Report and Review of Literature

Neonatal Ventriculitis with Multi Drug Resistant Acinetobactor baumanii: A Case Report and Review of Literature

Neonatal Bacterial Meningitis

Prevención y tratamiento de las infecciones del sitio operatorio en neurocirugía. Estado del arte

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