Intraventricular cerebrospinal fluid temperature analysis using <scp>MR</scp> diffusion‐weighted imaging thermometry in Parkinson's disease patients, multiple system atrophy patients, and healthy subjects

Sumida, Kaoru; Sato, Noriko; Ota, Miho; Sakai, Koji; Nippashi, Yasumasa; Yokoyama, Kota; Ito, Kei; Maikusa, Norihide; Imabayashi, Etsuko; Yamada, Kazuo; Murata, Miho; Kunimatsu, Akira; Ohtomo, Kuni

doi:10.1002/brb3.340

Cited by 22 publications

(14 citation statements)

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“…As demonstrated in our previous study, high T v was recorded in male patients with Parkinson's disease and multiple system atrophy, possibly due to altered mitochondrial function . Conversely, decreased cerebral temperatures were reported in individuals with minor head trauma and multiple sclerosis , reflecting the drop in cerebral metabolism.…”

Section: Discussionsupporting

confidence: 59%

“…We examined the senile changes in T v in an earlier investigation, in which 114 subjects aged 29–89 years were examined, with men and women analyzed separately. A decline in the DWI‐based intraventricular temperature in the elderly male subjects was demonstrated, but there was no such tendency for women . Since that analysis was performed without taking body temperature into account, we could not know how much the subjects' overall body temperature was responsible for T v .…”

Section: Discussionmentioning

confidence: 93%

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Intraventricular temperature measured by diffusion-weighted imaging compared with brain parenchymal temperature measured by MRSin vivo

et al. 2016

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We examined and compared the temperatures of the intraventricular cerebrospinal fluid (Tv ) and the brain parenchyma (Tp ) using MRI, with reference to the tympanic membrane temperature (Tt ) in healthy subjects. We estimated Tv and Tp values from data gathered simultaneously by MR diffusion-weighted imaging (DWI) and MRS, respectively, in 35 healthy volunteers (17 males, 18 females; age 25-78 years). We also obtained Tt values just before each MR examination to evaluate the relationships among the three temperatures. There were significant positive correlations between Tv and Tp (R = 0.611, p < 0.001). The correlation was also significant after correction for Tt (R = 0.642, p < 0.001). There was no significant correlation between Tv and Tt or between Tp and Tt in the men or the women. Negative correlations were found between Tv and age and between Tp and age in the males but not females. DWI thermometry seems to reflect the intracranial environment as accurately as MRS thermometry. An age-dependent decline in temperature was evident in our male subjects by both DWI and MRS thermometry, probably due to the decrease in cerebral metabolism with age. Copyright © 2016 John Wiley & Sons, Ltd.

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Section: Discussionsupporting

confidence: 59%

Section: Discussionmentioning

confidence: 93%

Intraventricular temperature measured by diffusion-weighted imaging compared with brain parenchymal temperature measured by MRSin vivo

et al. 2016

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“…Motion in CSF is thought to alter the measurement and using specific diffusion directions and histogram analysis methods have been proposed to reduce the effects of flow on the measurement. [10][11][12] Core brain temperature measured using DBT has been shown to be reduced in aging, 13 mild traumatic brain injury, 14 neurodegenerative disease 15 and multiple sclerosis and is increased in Moyamoya 16 and normal pressure hydrocephalus. 17 However, these studies show large unexplained fluctuations between individual core brain temperature measurements in both healthy controls and patients (between 36 and 41°C), which in some studies produces average lateral ventricular temperatures 1-2°C higher than core body temperature (e.g., DBT-measured core brain temperature in 14 controls range 35.2-39.7°C, with average 38.0°C while average tympanic temperature was 36.6°C 14 ; Moyamoya DBT measured average ventricular temperature was 38.3°C, range 36.0-40.9°C 16 ; DBT measured core brain temperatures in controls range 34.4-41.3°C 15 ).…”

Section: Introductionmentioning

confidence: 99%

Effects of motion and b‐value on apparent temperature measurement by diffusion‐based thermometry MRI: eye vitreous study

et al. 2020

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Purpose: To make noninvasive measurements of temperature in the posterior chamber (vitreous) of the eye using diffusion-based thermometry (DBT) magnetic resonance imaging (MRI) and to explain variability in these measurements due to choice of b-value and the effects of motion. Methods: Phantom studies of human vitreous and distilled water were performed using b-values from 0 to 1500 s/mm 2 to determine the liquid-specific calibration factor for vitreous as well as to determine the temperature offsets due to sampling the diffusion curve using three higher routine clinical b-values (b = 0, 500, 1000 s/mm 2) or four lower b-values (b = 0, 200, 400, 600 s/mm 2), thought to be optimized for fluids. Retrospective ROI-based measurements of apparent diffusion coefficient on single slices as well as multi-slice histograms of the eyes were made in six patients with peri-orbital cellulitis and 11 age-matched controls, to assess for temperature changes in the presence of periorbital inflammation. A prospective study of ten repeated measurements of eye temperature using both high and lower b-value sampling was performed in ten asymptomatic volunteers to determine the reproducibility of eye temperature measurements in-vivo as well as to estimate vitreous temperature in the absence of motion. Results: The diffusion coefficient of vitreous (2,088 AE 13 × 10 −6 mm 2 /s) was significantly lower (−1.9%, P < 0.001) compared to distilled water (2,128 AE 12 × 10 −6 mm 2 /s). The calibration factor for temperature measurements of vitreous using DBT is +0.74 AE 0.06°C. Temperature offsets were smaller (<−0.2°C, P < 0.01) when using larger routine clinical b-values to estimate the diffusion coefficient compared to using a series of lower b-values (<−1.0°C, P < 0.001). Two-dimensional singleslice ROI-based measurement showed significant temperature differences (ΔT I-C = 2.5 AE 1.2°C, P < 0.001) between the eyes of patient with peri-orbital cellulitis, higher on the side of inflammation. There was no significant difference in eye temperature when using the 3D histogram (which is likely due to motion averaging as significant slice-to-slice variation was present). However, significant differences in the 3D temperature histograms between the two eyes was observed in one out of six patients. Prospective eye temperature measurements in healthy volunteers showed significant intra-and intersubject variability (33.8-41.6°C), which was caused by eye motion. This resulted in +2.4°C cohortwide elevation in temperature when three b-values were used and +4.7°C when four b-values were used. Using a pattern of elevated temperature at the periphery of the eye to detect motion, eye temperature is the absence of motion was estimated to be 34.5 AE 0.4°C with three higher b-values and 34.6 AE 1.9°C with four lower b-values; this temperature corresponds with prior mathematical simulations of eye temperature as well as boundary conditions. Conclusions: Globe vitreous temperature has been measured noninvasively using DBT MRI. Using routine clinical b-values of b...

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“…Yamada et al [26] found that the braincore temperature was higher in moyamoya disease patients than in normal controls. Brain-core temperature increases in patients with Parkinson's disease [27] and schizophrenia [28], while no significant modification in brain-core temperature was founded in Alzheimer's patients compared with healthy subjects [29].…”

Section: Discussionmentioning

confidence: 94%

Brain-core temperature of patients before and after orthotopic liver transplantation assessed by DWI thermometry

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et al. 2018

Jpn J Radiol

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Intraventricular cerebrospinal fluid temperature analysis using MR diffusion‐weighted imaging thermometry in Parkinson's disease patients, multiple system atrophy patients, and healthy subjects

Cited by 22 publications

References 48 publications

Intraventricular temperature measured by diffusion-weighted imaging compared with brain parenchymal temperature measured by MRSin vivo

Intraventricular temperature measured by diffusion-weighted imaging compared with brain parenchymal temperature measured by MRSin vivo

Effects of motion and b‐value on apparent temperature measurement by diffusion‐based thermometry MRI: eye vitreous study

Brain-core temperature of patients before and after orthotopic liver transplantation assessed by DWI thermometry

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