Intraventricular hemorrhage in term neonates caused by sinovenous thrombosis

Wu, Yvonne W.; Hamrick, Shannon E. G.; Miller, Steven P.; Haward, Marlyse F.; Lai, Mark H. C.; Callen, P W; Barkovich, A. James; Ferriero, Donna M.

doi:10.1002/ana.10619

Cited by 135 publications

(65 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Among term neonates with IVH, underlying CSVT is documented in nearly one-third (31%) and is more likely when thalamic hemorrhage is present ( P 5 .03). 385 The association between the use of UFH and the occurrence of IVH in preterm neonates remains controversial. In the review by Barrington,347 no association between heparin exposure and IVH was identifi ed.…”

Section: Cerebral Sinovenous Thrombosis In Neonatesmentioning

confidence: 99%

Antithrombotic Therapy in Neonates and Children

Monagle

Chan

Goldenberg

et al. 2012

Chest

1,269

559

View full text Add to dashboard Cite

Section: Cerebral Sinovenous Thrombosis In Neonatesmentioning

confidence: 99%

Antithrombotic Therapy in Neonates and Children

Monagle

Chan

Goldenberg

et al. 2012

Chest

1,269

559

View full text Add to dashboard Cite

“…[1][2][3]11,12 One-third of term neonates with intraventricular haemorrhage suffer from CSVT. 13 Two to 10 per cent of the neonates 2,4 and 11 to 17% of the older children died after CSVT 2,6 . A recurrence of the thrombosis occurred in 6%.…”

mentioning

confidence: 99%

Cerebral sinus venous thrombosis in Swiss children

Grunt

Wingeier

Wehrli

et al. 2010

Develop Med Child Neuro

104

View full text Add to dashboard Cite

AIM To describe the characteristics of paediatric cerebral sinus venous thrombosis (CSVT) inSwitzerland.METHOD Data on clinical features, neuroimaging, risk factors, and treatment were collected for all children in Switzerland younger than 16 years of age who had CSVT between January 2000 and December 2008. A follow-up examination and a cognitive assessment were performed (mean follow-up period 26mo). Differences between neonates and children (patients older than 28d) were assessed and predictors of outcome were determined.RESULTS Twenty-one neonates (14 males, seven females; mean age 9d, SD 8d) and 44 children (30 males, 14 females; mean age 8y 7mo, SD 4y 5mo) were reported. The incidence of paediatric CSVT in Switzerland was 0.558 per 100 000 per year. In neonates, the deep venous system was more often involved and parenchymal injuries were more common. The strongest predictor of poor outcome was neonatal age (odds ratio 17.8, 95% confidence interval 0. 847-372.353). Most children showed global cognitive abilities within the normal range, but impairments in single cognitive subdomains were frequent.INTERPRETATION Paediatric CSVT is rare. Its outcome is poor in neonates. Most children have good neurological outcomes, but some patients have individual neuropsychological impairments.Cerebral sinus venous thrombosis (CSVT) in children is rare. Based on a Canadian registry, its incidence is 0.67 cases per 100 000 children per year; neonates were the most commonly affected.1 The risk factors in neonates include maternal conditions, delivery complications, and neonatal comorbidities. [1][2][3][4] Older children often use prothrombotic agents such as oral contraceptives or suffer from infections of the head and neck or a chronic systemic illness.5-8 Prothrombotic states are increased in patients who suffer from CSVT.1,9 The superficial venous system is most commonly involved. 1,6,10 Parenchymal injuries, such as ischaemic or haemorrhagic infarcts, are often observed in conjunction with CSVT. [1][2][3]11,12 One-third of term neonates with intraventricular haemorrhage suffer from CSVT. 13Two to 10 per cent of the neonates 2,4 and 11 to 17% of the older children died after CSVT 2,6 . A recurrence of the thrombosis occurred in 6%.10 Thirty-eight per cent of the patients exhibited neurological deficits, such as motor impairment, cognitive problems, or epilepsy.1 The long-term outcome was especially poor in neonates. 1,2,4 In older children who suffered from CSVT, cognitive assessments with standardized and agenormalized tests showed cognitive performance within the normal range, 14,15 but individual impairments were seen in up to 20% of the patients. 14In the present study, we aimed to describe the incidence, clinical manifestation, neuroimaging findings, risk factors, and treatment of children suffering from CSVT in Switzerland. In addition, we systematically assessed outcomes after CSVT and identified predictors of poor outcome. METHOD Participants and data collectionThe Swiss Neuropaediatric Stroke Registry (SNPSR) is a...

show abstract

“…6 Consequently, it has been reported that sinus thrombosis causes impaired deep venous return and increased venous pressure, which may lead to intraventricular hemorrhage originating in the basal ganglia or thalamus. 14,15 We have to consider the benefit of antiplatelet or anticoagulation therapy in such patients. However, preventive antiplatelet therapy for sinus thrombosis has not been definitely accepted.…”

Section: Treatment Interventions For Swsmentioning

confidence: 99%

Sturge-Weber syndrome with spontaneous intracerebral hemorrhage in childhood

Nakajima¹,

Sugano²,

Iimura³

et al. 2014

PED

View full text Add to dashboard Cite

A girl aged 2 years 10 months suddenly went into a deep coma and demonstrated left hemiplegia. At birth, she had exhibited a left-sided facial port-wine stain typical of Sturge-Weber syndrome (SWS) and involving the V1 and V2 distributions of the trigeminal nerve. Computed tomography showed a right thalamic hemorrhage with acute hydrocephalus. Magnetic resonance imaging with Gd enhancement 8 months before the hemorrhage had shown a patent superior sagittal sinus (SSS) and deep venous system. Magnetic resonance imaging and MR angiography studies 2 months before the hemorrhage had revealed obstruction of the SSS and right internal cerebral vein (ICV). Given that a digital subtraction angiography study obtained after the hemorrhage did not show the SSS or right ICV, the authors assumed that impaired drainage was present in the deep venous system at that stage. The authors speculated that the patient's venous drainage pattern underwent compensatory changes because of the occluded SSS and deep venous collectors, shifting outflow through other cortical venous channels to nonoccluded dural sinuses. Sudden congestion (nearly total to total obstruction) of the ICV may have caused the thalamic hemorrhage in this case, which is the first reported instance of pediatric SWS with intracerebral hemorrhage and no other vascular lesion. Findings suggested that the appearance of major venous sinus occlusion in a child with SWS could be a warning sign of hemorrhage.

show abstract

Intraventricular hemorrhage in term neonates caused by sinovenous thrombosis

Cited by 135 publications

References 21 publications

Antithrombotic Therapy in Neonates and Children

Antithrombotic Therapy in Neonates and Children

Cerebral sinus venous thrombosis in Swiss children

Sturge-Weber syndrome with spontaneous intracerebral hemorrhage in childhood

Contact Info

Product

Resources

About