Intraventricular insulin adjacent to the arcuate nucleus reduced the formalin-induced pain through dorsal raphe nucleus opioid receptors in the STZ-induced diabetic rats

Khaleghzadeh‐Ahangar, Hossein; Khandan, Shaghayegh; Khosravi, Saeideh

doi:10.1016/j.bbr.2021.113662

Cited by 2 publications

(1 citation statement)

References 27 publications

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“…Insulin has the ability to penetrate brain regions such as the hypothalamus and the pons [20]. Insulin receptors have been found in the arcuate nucleus of the hypothalamus [21]. Neurons sensitive to glucose-related signalling are located in the ventral medial nucleus of the hypothalamus [22].…”

Section: Regulation Of Food Consumption Dependent On Insulin Signalli...mentioning

confidence: 99%

Impaired Brain Insulin Signalling,a Potential Cause of Obesity: A Review of Literature

Bukowska

2022

Clinical Diabetology

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Objective: Obesity is a major health problem in the modern world, which together with other conditions such as cardiovascular disease, hypertension and type 2 diabetes, can pose a direct threat to health and life. Obesity is often accompanied by insulin resistance, which has been shown to occur in both peripheral and central tissues. Brain insulin resistance is a less well understood and less described phenomenon than peripheral insulin resistance, but equally important and worthy of attention. Materials and methods: This review was written using the PubMed database. Articles were searched using keywords such as: insulin resistance, dopamine, obesity, cerebral insulin resistance, mesolimbic pathway, insulin, hypothalamus, feeding. The results of the studies within each phenomenon were analysed, compared and, on this basis, common conclusions were drawn. Results: Available scientific data indicate a correlation between insulin signalling in the brain and the function of the hypothalamic centres of hunger and satiety and the dopaminergic mesolimbic pathway, which is part of the reward system. The phenomenon of hyperphagia in obese individuals with insulin resistance can be explained by potentially reduced hypothalamic satiety signalling with simultaneously increased hunger signalling, and impaired dopaminergic transmission within the mesolimbic pathway, due to impaired insulin activity in the brain. Conclusions: The purpose of this article is to show a new potential direction for future obesity research and treatments, which would be based on the function of insulin-dependent brain centres regulating food intake. Improving insulin signalling in these areas could contribute to reduction in hyperphagia as well as reduction in excessive body weight.

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Section: Regulation Of Food Consumption Dependent On Insulin Signalli...mentioning

confidence: 99%

Impaired Brain Insulin Signalling,a Potential Cause of Obesity: A Review of Literature

Bukowska

2022

Clinical Diabetology

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show abstract

Endogenous opiates and behavior: 2022

Bodnar

2023

Peptides

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Intraventricular insulin adjacent to the arcuate nucleus reduced the formalin-induced pain through dorsal raphe nucleus opioid receptors in the STZ-induced diabetic rats

Cited by 2 publications

References 27 publications

Impaired Brain Insulin Signalling,a Potential Cause of Obesity: A Review of Literature

Impaired Brain Insulin Signalling,a Potential Cause of Obesity: A Review of Literature

Endogenous opiates and behavior: 2022

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