2024
DOI: 10.7150/thno.87791
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Intravital imaging of splenic classical monocytes modifying the hepatic CX3CR1+ cells motility to exacerbate liver fibrosis via spleen-liver axis

Chenlu Han,
Yujie Zhai,
Yuke Wang
et al.

Abstract: CX3CR1 + cells play a crucial role in liver fibrosis progression. However, changes in the migratory behavior and spatial distribution of spleen-derived and hepatic CX3CR1 + cells in the fibrotic liver as well as their influence on the liver fibrosis remain unclear. Methods: The CX3CR1 GFP/+ transgenic mice and CX3CR1-KikGR transgenic mice were used to establish the CCl4-induced liver fibrosis model. Splenectomy, adoptive transfusio… Show more

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