Intravitreal application of membrane-permeable analogs of cyclic GMP increases serotonin N-acetyltransferase (NAT) activity in retinas of light-exposed chicks: Comparison with the effect of cyclic AMP analogs and darkness

Nowak, Jerzy Z.; Wawrocka, Marlena

doi:10.1016/0304-3940(93)90550-5

Cited by 2 publications

(2 citation statements)

References 15 publications

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“…consistent with the present results, we have shown that cyclic GMP content in the hamster retina varies significantly along a 24-h period, exhibiting maximal values during the night (Faillace et al, 1996~). Moreover, light during the night abolished the nocturnal increase in both cyclic GMP and melatonin levels (Faillace et al, 1994 cyclic GMP increases NAT activity in retinas of lightexposed chicks (Nowak and Wawrocka, 1993), possibly acting through the cyclic AMP pathway. We have previously shown that analogues of cyclic GMP increase Ca2+ uptake by a retinal synaptosomal fraction (Faillace et al, 1996b).…”

Section: Discussionsupporting

confidence: 78%

Effect of GABA on Melatonin Content in Golden Hamster Retina

Jaliffa

Faillace

Lacoste

et al. 1999

Journal of Neurochemistry

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Abstract:The effect of GABA on melatonin content in vitro was studied in the golden hamster retina. GABA significantly increased melatonin levels in a dose-dependent manner, its effect being reversed by a GABA, receptor antagonist, bicuculline, but not by saclofen, a GABA, antagonist. Moreover, an equimolar concentration of muscimol, a GABA, receptor agonist, significantly increased retinal melatonin content, whereas baclofen, a GABA, receptor agonist, was ineffective. The darknessinduced increase in melatonin content in vitro was inhibited by bicuculline, whereas saclofen was ineffective. Retinal GABA turnover rate was significantly higher at midnight than at midday. GABA significantly decreased cyclic AMP and increased cyclic GMP accumulation in the golden hamster retina. The effect of GABA on both nucleotide levels was reversed by bicuculline, but baclofen had no effect. Cyclic GMP analogues (i.e., 8-bromoguanosine 3',5'-cyclic monophosphate and 2'-0-dibutyrylguanosine 3',5'-cyclic monophosphate) significantly increased retinal melatonin content in vitro. Taken together, these results support the hypothesis that GABA may be important for the "dark message" in the hamster retina. Key Words: GABA-Melatonin-Cyclic AMPCyclic GMP-Hamster retina.

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Section: Discussionsupporting

confidence: 78%

Effect of GABA on Melatonin Content in Golden Hamster Retina

Jaliffa

Faillace

Lacoste

et al. 1999

Journal of Neurochemistry

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“…Yet, all three melatonin receptor subtypes appear to act through a G i protein to inhibit adenylate cyclase and decrease cAMP levels (Reppert, 1997), while intravitreal injection of both cAMP and cGMP analogs increases AA-NAT activity in chick retinas (Nowak & Wawrocka, 1993). In chick retina, a light pulse during the night, presumably through a reduction in cAMP levels, exposes AA-NAT protein to proteolytic degradation (Iuvone et al, 2002).…”

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confidence: 99%

Melatonin receptor mRNA localization and rhythmicity in the retina of the domestic chick, Gallus domesticus

Natesan

Cassone

2002

Vis Neurosci

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The indoleamine hormone melatonin is synthesized and released by photoreceptors during the night within the chick retina, and confers timing information to modulate retinal physiology. Three subtypes of melatonin receptor with nearly identical pharmacological profiles have been described in chickens and are present in the retina. In this study, the spatial localization and temporal pattern of the mRNA for each of these receptors within the retina are described. The localization and rhythmicity of receptor mRNA were analyzed using in situ hybridization and RNase protection assay, respectively, with probes against specific nucleotide sequences encoding these receptors. Mel1A and Mel1C receptor mRNA have similar patterns of expression, primarily in the inner segments of photoreceptors, vitread portion of the inner nuclear layer, and in the retinal ganglion cell layer. Mel1B receptor mRNA is expressed at higher levels in the retina, with expression in photoreceptors, throughout the inner nuclear layer, and in the ganglion cell layer. Mel1A receptor mRNA is rhythmic in both light:dark (LD) cycles and in constant darkness (DD); Mel1A peaks during midday and mid-subjective day, respectively. Mel1C receptor mRNA is also rhythmically expressed in LD, but with a lower amplitude, such that transcript is high during the day and low during the night. In DD, Mel1C rhythms become 180 deg out of phase with a slight increase at night. Mel1B mRNA expression was highly variable and arrhythmic.

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Intravitreal application of membrane-permeable analogs of cyclic GMP increases serotonin N-acetyltransferase (NAT) activity in retinas of light-exposed chicks: Comparison with the effect of cyclic AMP analogs and darkness

Cited by 2 publications

References 15 publications

Effect of GABA on Melatonin Content in Golden Hamster Retina

Effect of GABA on Melatonin Content in Golden Hamster Retina

Melatonin receptor mRNA localization and rhythmicity in the retina of the domestic chick, Gallus domesticus

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