Intravitreal Bevacizumab for Choroidal Neovascularization Associated With Choroidal Nevus

Abstract

Intravitreal bevacizumab appears to be an effective treatment option for CNV secondary to choroidal nevus. In some cases, depending on the proximity of the CNV to the foveola, photodynamic therapy or conventional laser may be useful adjunctive therapy.

Choroidal naevi complicated by choroidal neovascular membrane and outer retinal tubulation

“…In agreement with Chiang et al 4 a clinical trial is unlikely for this rare entity. All the naevi in our study and all but one in previously reported series had no evidence of growth 6.…”

“…The type of CNV developing over a choroidal naevus is also variable. In previous reports most of the CNV types were either exclusively classic3 5 or exclusively occult4 or unspecified 6. In our series, choroidal neovascularisation was classic or predominantly classic in 46% of eyes (8/17) and occult or minimally classic in 53% (9/17).…”

“…Bevacizumab and ranibizumab were similarly efficacious in AMD-related CNV 12 13. A recent study examined the efficacy of bevacizumab for occult CNV secondary to naevus in 10 eyes 4. In this study anatomical and functional (mean of 3 Snellen lines of improved visual acuity) improvement was noted in 60% of eyes without ocular or systemic adverse effects.…”

“…In our series mean elevation was smaller at 0.8 mm and mean basal diameter was 4 mm. Most of the lesions previously reported had an elevation of less than 2.5 mm, excluding two eyes at 2.5–5.3 mm (attributed to the presence of haemorrhage and fibrosis) 4 6…”

“…Various treatment modalities have been used in the past such as argon laser,2 photodynamic therapy (PDT),3 or more recently, anti-VEGF agents 4. The aim of this study is to present the assessment and management outcomes of a series of eyes with CNV secondary to a choroidal naevus.…”