Intravitreal ranibizumab in the treatment of choroidal neovascular membrane secondary to punctate inner choroidopathy

Resolution of Choroidal Neovascularization Secondary to Punctate Inner Choroidopathy (PIC) with Intravitreal Anti-VEGF Agents: A Case Series

“…All fouor cases showed no angiographic leakage at month 3 and at month 6. 1 Vossmerbaeumer et al also report a case treated with intravitreal bevacizumab. They report at 28 weeks after the first of three injections visual acuity had improved from 20/40 to 20/25 with reduction of the neovascular lesion by 30% with no exudation.…”

“…1 Chan et al report four cases of choroidal neovascularization secondary to PIC treated with intravitreal bevacizumab. The follow-up was for a maximum of six months after treatment was initiated.…”

Choroidal neovascularization due to punctate inner choroidopathy: long-term follow-up and review of literature

“…Fong et al21 and Chan et al22 reported encouraging results on combined PDT with oral or intravitreal steroid. Finally, Vossmerbaeumer et al17 reported the successful outcome in a case of CNV secondary to PIC with intravitreal anti-VEGF treatment (bevacizumab), and Leung et al18 reported favorable results in a case with intravitreal ranibizumab after a short-term follow-up.…”

“…A variety of treatment options have been described, including PDT,10–16 use of local and systemic steroid monotherapy,2,4,9 submacular surgery,6,7 and recently anti-VEGF agents 17,18. Corticosteroids have also been advocated as a therapeutic adjunct to PDT, in particular due to their dual anti-inflammatory and antiangiogenetic properties 19,20…”

“…The variety of treatment options for the CNV in PIC reflects the puzzling absence of consistent results and includes submacular surgery,6,7 steroids,4,8,9 photodynamic therapy (PDT),10–16 and most recently anti-VEGF agents 17,18. In cases of extrafoveal or juxtafoveal lesion, CNV laser photocoagulation can also be attempted 4.…”