Intravitreal ranibizumab injection combined with photodynamic therapy for polypoidal choroidal vasculopathy

Li, Jia; Sun, Jianhua; Li, Bing; Liu, Zheli

doi:10.3892/etm.2017.5565

Cited by 1 publication

(2 citation statements)

References 28 publications

(27 reference statements)

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“…After the removal of duplicates through systematic (EndNote) and manual matching, the remaining 747 articles were assessed. Finally, 4 prospective cohort studies 12 , 15 , 16 , 18 and 7 RCTs 7 – 11 , 14 were included. The flow diagram is illustrated in Supplementary 2 .…”

Section: Resultsmentioning

confidence: 99%

“…Notably, PDT can be used alone or in combination with anti-VEGF to treat PCV 1,6 . However, choosing the appropriate treatment for PCV is still a critical aspect of clinical practice.Several prospective observational studies and randomized clinical trials (RCTs) have reported the efficacy of anti-VEGF agents, PDT, and their combination for treating PCV [7][8][9][10][11][12][13][14][15][16][17][18] . These studies have further subdivided combined therapy into early combination and late combination therapy.…”

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confidence: 99%

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Systematic review with network meta-analysis of antivascular endothelial growth factor use in managing polypoidal choroidal vasculopathy

Chi

Kang

Huang

2021

Sci Rep

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Polypoidal choroidal vasculopathy (PCV) is a vision-threatening disease common in Asian populations. However, the optimal treatment for PCV remains under debate. We searched the databases with optimal searching strategy. The study included randomized clinical trials and prospective studies that recruited patients with active PCV who had received interventions, including PDT, anti-VEGF, or a combination of PDT and anti-VEGF. The Grading of Recommendations Assessment, Development, and Evaluation methodology was used for rating the quality of evidence. Our study included 11 studies involving 1277 patients. The network meta-analysis of RCTs revealed the anti-VEGF group, early combination group, and late combination group had significant BCVA changes compared with the PDT group. Early combination therapy led to a significant decrease in CRT compared with PDT, anti-VEGF, and late combination therapy. Additionally, the early combination group had a significantly higher complete polyp regression rate than the anti-VEGF group. No significant differences were detected in the analysis of the number of anti-VEGF injections and safety profile. This network meta-analysis revealed that early combination therapy exhibited better efficacy related to anatomical outcomes than other therapies. Nonetheless, no significant differences related to BCVA change could be detected between anti-VEGF and late combination therapy.

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Section: Resultsmentioning

confidence: 99%

mentioning

confidence: 99%

Systematic review with network meta-analysis of antivascular endothelial growth factor use in managing polypoidal choroidal vasculopathy

Chi

Kang

Huang

2021

Sci Rep

View full text Add to dashboard Cite

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Intravitreal ranibizumab injection combined with photodynamic therapy for polypoidal choroidal vasculopathy

Abstract: Abstract. The aim of the present study was to evaluate the efficacy of combination treatment with intravitreal

Cited by 1 publication

References 28 publications

Systematic review with network meta-analysis of antivascular endothelial growth factor use in managing polypoidal choroidal vasculopathy

Systematic review with network meta-analysis of antivascular endothelial growth factor use in managing polypoidal choroidal vasculopathy

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