Intravitreal Triamcinolone Acetonide Treatment for Serpiginous Choroiditis

Adigüzel, Ufuk; Sari, Ayca; Ozmen, Cengiz; Öz, Özay

doi:10.1080/09273940601025974

Cited by 15 publications

(9 citation statements)

References 17 publications

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“…Intravenous, 123 peribulbar, 123 subtenon, 69 and intravitreal 4,86,129 corticosteroid injections have also been used with variable success. Intravitreal injection of triamcinolone acetonide was first used in patients for whom systemic corticosteroids were contraindicated.…”

Section: Managementmentioning

confidence: 99%

“…In most patients, however, diagnostic studies seeking an infectious cause remain inconclusive; thus, the intraocular inflammation is treated with corticosteroids and immunosuppresants without the use of anti-microbial agents, on the assumption that this choroidal inflammation is driven by an underlying, organ-specific, autoimmune disorder. 4,146,153,159,162,178,180 …”

Section: Introductionmentioning

confidence: 99%

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Serpiginous Choroiditis and Infectious Multifocal Serpiginoid Choroiditis

Khanamiri

Rao

2013

Survey of Ophthalmology

176

120

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Serpiginous choroiditis (SC) is a posterior uveitis displaying a geographic pattern of choroiditis, extending from the juxtapapillary choroid and intermittently spreading centrifugally. The choroiditis involves the overlying retinal pigment epithelium, and the outer retina. This intraocular inflammation typically involves both eyes in otherwise healthy, middle-aged individuals with no familial or ethnic predilection. Pathogenesis is unclear; however, based on limited histopathologic studies, favorable response to immunosuppressive agents, and the absence of association with systemic or local infectious or noninfectious diseases, an organ-specific autoimmune inflammation seems likely to be the underlying process. Patients, particularly from tuberculosis-endemic regions, may present with fundus changes simulating SC, but show evidence of active tuberculosis and/or the presence of mycobacterial DNA in the aqueous humor. This has been referred to as serpiginous-like choroiditis, but we prefer the description multifocal serpiginoid choroiditis (MSC). We present the distinguishing features of SC and infectious multifocal serpiginoid choroiditis simulating SC. The distinction is crucial to avoid unnecessarily treating SC with antimicrobial agents. Advances in diagnostic and imaging modalities can help differentiate SC from MSC. Novel local and systemic treatment approaches improve the outcome and preserve vision in SC.

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Section: Managementmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Serpiginous Choroiditis and Infectious Multifocal Serpiginoid Choroiditis

Khanamiri

Rao

2013

Survey of Ophthalmology

176

120

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“…Triamcinolone acetonide intravitreal injections have been shown to be useful in macular active serpiginous lesions,13 in the presence of systemic corticosteroids contraindication,15 and in secondary choroidal neovascularisation 17. Reported disease-free remission time with intravitreal triamcinolone injections ranged from 6 to 10 months following the administration of treatment.…”

Section: Discussionmentioning

confidence: 99%

Dexamethasone intravitreal implant in serpiginous choroiditis

et al. 2016

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“…33 Several cases have been reported of rapid remission of infl ammation after intravitreal TA injection. 34,35,36 The infl ammation has been reported to be decreased for up to 10 months. 35 In addition, cases of associated macular edema rapidly resolved after TA.…”

Section: Autoimmune Uveitismentioning

confidence: 99%

“…35 In addition, cases of associated macular edema rapidly resolved after TA. 34,36 Birdshot retinochoroidopathy, also called vitiliginous, is characterized by bilateral cream-colored lesions in the posterior pole. It is has a presumed autoimmune etiology as it is highly associated with HLA-A29.…”

Section: Autoimmune Uveitismentioning

confidence: 99%

Intravitreal triamcinolone for intraocular inflammation and associated macular edema

Couch¹

2008

OPTH

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Triamcinolone acetonide (TA) is a corticosteroid that has many uses in the treatment of ocular diseases because of its potent anti-infl ammatory and anti-permeability actions. Intraocular infl ammation broadly referred to as uveitis can result from several causes, including the immune system and after ophthalmic surgery. One of the most common reasons for vision loss with uveitis is macular edema. TA has been used for many years as an intravitreal injection for the treatment of ocular diseases. Several case control studies have been reported showing the effi cacy of TA in the treatment of intraocular infl ammation and associated macular edema caused by Behcet's disease, Vogt-Koyanagi-Harada syndrome, sympathetic ophthalmia and white dot syndromes. It has also been shown effi cacious in cases of pars planitis and idiopathic posterior uveitis. Some authors have reported its use in postoperative cystoid macular edema. Many of the studies on the use of TA in controlling intraocular infl ammation and concomitant macular edema showed its effect to be transient in many patients requiring reinjection. Complications can arise from intravitreal injection of TA including elevated intraocular pressure and cataract. Rarely, it can be associated with infectious and non-infectious endophthalmitis. TA may be useful as an adjuvant in the treatment of uveitis and its associated macular edema, especially in patients resistant or intolerant to standard treatment.

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Intravitreal Triamcinolone Acetonide Treatment for Serpiginous Choroiditis

Abstract: Single dose intravitreal triamcinolone acetonide injection is sufficient for controlling the active lesions in serpiginous choroiditis. It needs further evaluation as an alternative treatment for achieving rapid and significant visual acuity recovery.

Cited by 15 publications

References 17 publications

Serpiginous Choroiditis and Infectious Multifocal Serpiginoid Choroiditis

Serpiginous Choroiditis and Infectious Multifocal Serpiginoid Choroiditis

Dexamethasone intravitreal implant in serpiginous choroiditis

Intravitreal triamcinolone for intraocular inflammation and associated macular edema

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