Intravoxel Incoherent Motion Magnetic Resonance Imaging in Partially Nephrectomized Kidneys

Schneider, M; Dietrich, Olaf; Ingrisch, Michael; Helck, Andreas; Winter, Katharina; Reiser, Maximilian; Staehler, Michael; Casuscelli, Jozefina; Notohamiprodjo, Mike

doi:10.1097/rli.0000000000000244

Cited by 18 publications

(24 citation statements)

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“…DWI is a powerful MRI technique used for imaging molecular movement or diffusion that reflects changes in microstructure of biological tissues . Previous studies have confirmed that IVIM‐DWI can be used to assess renal function . However, renal pathology plays an important role in guiding therapy and follow‐up of CKD patients.…”

Section: Discussionmentioning

confidence: 99%

Chronic kidney disease: Pathological and functional evaluation with intravoxel incoherent motion diffusion‐weighted imaging

Mao

Zhou

Zeng

et al. 2017

Magnetic Resonance Imaging

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Section: Discussionmentioning

confidence: 99%

Chronic kidney disease: Pathological and functional evaluation with intravoxel incoherent motion diffusion‐weighted imaging

Mao

Zhou

Zeng

et al. 2017

Magnetic Resonance Imaging

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“…Earlier studies indicated that IVIM parameters were sensitive to chronic renal impairment, such as the grade of clear cell renal cell carcinoma, diabetic kidney, ureteral obstruction and renal artery stenosis . The decrease in renal cortical perfusion can explain the alteration in magnetic resonance parameters when renal function changes . Therefore, we presumed that diffusion MRI, which is able to characterize renal microstructure and microcirculation, can potentially detect acute changes in renal function after exposure to high‐pressure renal pelvic perfusion.…”

Section: Introductionmentioning

confidence: 64%

Acute renal impairment characterization using diffusion magnetic resonance imaging: Validation by histology

Zhu

et al. 2019

NMR in Biomedicine

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Diffusion magnetic resonance imaging has been demonstrated to be a simple, noninvasive and accurate method for the detection of renal microstructure and microcirculation, which are closely linked to renal function. Moreover, serum endothelin‐1 (ET‐1) was also reported as a good indicator of early renal injury. The aim of this study was to evaluate the feasibility and capability of diffusion MRI and ET‐1 to detect acute kidney injury by an operation simulating high‐pressure renal pelvic perfusion, which is commonly used during ureteroscopic lithotripsy. Histological findings were used as a reference. Fourteen New Zealand rabbits in an experimental group and 14 in a control group were used in this study. Diffusion tensor imaging and intravoxel incoherent motion diffusion‐weighted imaging were acquired by a 3.0 T MRI scanner. Significant corticomedullary differences were found in the values of the apparent diffusion coefficient (ADC), pure tissue diffusion, volume fraction of pseudo‐diffusion (fp) and fractional anisotropy (FA) (P < 0.05 for all) in both preoperation and postoperation experimental groups. Compared with the control group, the values of cortical fpmean, medullary ADCmean and FAmean decreased significantly (P < 0.05) after the operation in the experimental group. Also, the change rate of medullary ADCmean in the experimental group was more pronounced than that in the control group (P = 0.018). No significant change was found in serum ET‐1 concentration after surgery in either the experimental (P = 0.80) or control (P = 0.17) groups. In the experimental group, histological changes were observed in the medulla, while no visible change was found in the cortex. This study demonstrated the feasibility of diffusion MRI to detect the changes of renal microstructure and microcirculation in acute kidney injury, with the potential to evaluate renal function. Moreover, the sensitivity of diffusion MRI to acute kidney injury appears to be superior to that of serum ET‐1.

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“…Our analysis of kidneys both contralateral and ipsilateral to renal lesions suggests functional compromise, perhaps reflecting a general deficit that patients have in comparison to controls. Renal ADC has previously been shown to be decreased in the ipsilateral kidney postpartial nephrectomy, as well as in renal artery stenosis and renal failure …”

Section: Discussionmentioning

confidence: 97%

REnal Flow and Microstructure AnisotroPy (REFMAP) MRI in Normal and Peritumoral Renal Tissue

Liu

Mikheev

Rusinek

et al. 2018

Magnetic Resonance Imaging

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Intravoxel Incoherent Motion Magnetic Resonance Imaging in Partially Nephrectomized Kidneys

Cited by 18 publications

References 0 publications

Chronic kidney disease: Pathological and functional evaluation with intravoxel incoherent motion diffusion‐weighted imaging

Chronic kidney disease: Pathological and functional evaluation with intravoxel incoherent motion diffusion‐weighted imaging

Acute renal impairment characterization using diffusion magnetic resonance imaging: Validation by histology

REnal Flow and Microstructure AnisotroPy (REFMAP) MRI in Normal and Peritumoral Renal Tissue

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