Intricate role of sleep deprivation in modulating depression: focusing on BDNF, VEGF, serotonin, cortisol, and TNF-α

Vaseghi, Salar; Mostafavijabbari, Ali; Alizadeh, Mohammad-Sadegh; Ghaffarzadegan, Reza; Kholghi, Gita; Zarrindast, Mohammad‐Reza

doi:10.1007/s11011-022-01124-z

Cited by 18 publications

(6 citation statements)

References 277 publications

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“…Sleep deprivation leads to stress response and is correlated to anxiety, depression and cognitive decline [6]. Studies have proved that BDNF is a central neurotrophic factor that expressed in central nervous system, especially in hippocampus tissues, and there is strong evidence that BDNF plays a critical role in regulating sleep [18]. Increasing number of studies have shown decreased BDNF level in chronic sleep deprivation or stress [19], but acute sleep deprivation or stress was associated with fast increase in serum BDNF levels [20].…”

Section: Discussionmentioning

confidence: 99%

Curcumin inhibits expression of brain derived neurotrophic factor (BDNF) in hippocampus of mice with sleep deprivation

Ruan¹,

He²,

Cao³

et al. 2023

Trop. J. Pharm Res

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Purpose: To determine the inhibitory effect of curcumin on the expression of brain-derived neurotrophic factor (BDNF) in hippocampus of mice with sleep deprivation. Methods: Expressions of BDNF and miRNA-206 were evaluated using quantitative real time-polymerase chain reaction (qRT-PCR) in a sleep-deprived mouse model. Interaction of BDNF and miRNA-206 was assessed by dual luciferase and qPCR) assays. The effect of curcumin on BDNF and miRNA-206 was also determined by qRT-PCR. Results: Expressions of BDNF and miRNA-206 were significantly suppressed in hippocampus of mice in sleep deprivation group compared with control mice (p < 0.05). Treatment with miRNA-206 significantly suppressed the luciferase activity of wild type (WT) BDNF reporter gene vector (p < 0.05) rather than the mutated (mut) vectors. Inhibition of miRNA-206 upregulated RNA and protein levels of BDNF (p < 0.05), while curcumin treatment inhibited BDNF expression (p < 0.01) and upregulated miRNA-206 level (p < 0.01). Conclusion: Curcumin inhibits BDNF expression by upregulating miRNA-206 level in hippocampus tissues of mice in the sleep deprivation model. The relationship between BDNF and miRNA-206 might provide a new direction for the development of new therapeutics for sleep deprivation.

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Section: Discussionmentioning

confidence: 99%

Curcumin inhibits expression of brain derived neurotrophic factor (BDNF) in hippocampus of mice with sleep deprivation

Ruan¹,

He²,

Cao³

et al. 2023

Trop. J. Pharm Res

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“…A large number of clinical studies have shown that the serum BDNF level in patients with depression decreases, and after tibial treatment, the blood BDNF level shows a significant upward trend. [ 21 , 22 ] RTMS can improve brain metabolism and blood flow, increase cerebral cortex blood flow perfusion, promote nerve cell growth, and regulate the level of computer neurotransmitters, thus affecting cognitive function. [ 22 ] The present study found an increased BDNF levels in study group after treatment, which is consistent with previous studies.…”

Section: Discussionmentioning

confidence: 99%

“…[ 21 , 22 ] RTMS can improve brain metabolism and blood flow, increase cerebral cortex blood flow perfusion, promote nerve cell growth, and regulate the level of computer neurotransmitters, thus affecting cognitive function. [ 22 ] The present study found an increased BDNF levels in study group after treatment, which is consistent with previous studies. [ 23 , 24 ] The study by Vogel and Soti [ 25 ] suggests that after receiving rTMS treatment, patients with depression experience an increase in the release of dopamine from the striatum, an increase in serum BDNF levels, and an improvement in cognitive function.…”

Section: Discussionmentioning

confidence: 99%

Repetitive transcranial magnetic stimulation in the treatment of middle-aged and elderly major depressive disorder: A randomized controlled trial

Wang,

Fan,

Zhang

et al. 2023

Medicine

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Background: Studies have reported the use of repetitive transcranial magnetic stimulation (rTMS) in patients with major depressive disorder (MDD). However, most studies focus on antidepressant effect of rTMS, but few on cognitive aspects. The present study aimed to explore the effect of rTMS on BDNF levels and cognitive function in the treatment of middle-aged and elderly MDD. Methods: This was a randomized controlled trial. A total of 120 elderly patients with MDD treated in The Second Affiliated Hospital of Xi’an Medical University from January 2021 to January 2023 were selected as research subjects. The patients were randomly divided into control group (n = 60, patients received simple oral treatment with escitalopram and sham rTMS) and study group (n = 60, patients received oral treatment with escitalopram combined with rTMS) according to the random number table method. We compared the clinical efficacy, serum BDNF levels, and cognitive function between the 2 groups. Results: After treatment, the HAMD-17 score in the study group was lower than that in the control group [13.00 (12.00–16.00) vs 17.00 (15.00–19.00), P < .05], and the RBANS score was higher than that in the control group [166.00 (161.25–171.75) vs 133.00 (130.00–136.75), P < .05]. The total effective rate of the research group was 95.0%, which was higher than the 82.0% of the control group (P < .05). The serum BDNF levels [36.00 (33.00–38.00) vs 30.00 (28.00–32.00), P < .05] and MoCA scores [24.00 (22.00–26.75) vs 23.00 (21.00–25.00), P < .05] of the study group were higher than those of the control group. There were no significant adverse reactions during the treatment of both groups. Conclusions: Compared with oral escitalopram alone, repeated transcranial magnetic stimulation in the treatment of middle-aged and elderly patients with major depressive disorder can further improve the efficacy, and can more effectively improve the BDNF level and cognitive function, with ideal safety.

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“…Serotonin is also important for the regulation of sleep. 11 Insufficient serotonin may lead to sleep disturbance, which is one of the common symptoms of depression. Serotonin has also been implicated in appetite regulation.…”

Section: Pathogenesismentioning

confidence: 99%

Treatment of Depression with Acupuncture Based on Pathophysiological Mechanism

Sun,

Cao,

Xin

et al. 2024

IJGM

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Depression is a prevalent mental disorder and has a profound impact on an individual’s psychological and physical well-being. It is characterized by a persistently depressed mood, loss of interest, energy loss, and cognitive dysfunction. In recent years, more and more people have changed to mental diseases, such as depression, anxiety, mania and so on. In the incidence of depression, covering all ages, but still mainly young and middle-aged women. Traditional treatments for depression mainly rely on medication and psychotherapy, but these methods are not effective for all patients and are often accompanied by certain side effects. Therefore, finding safe and effective alternative or adjuvant treatments has become a priority. Here we highlight the research progress of acupuncture in the treatment of depression and to explore the mechanism of acupuncture in the treatment of depression. Acupuncture treatment of depression is an ancient and effective method, the mechanism involves multiple biological pathways, for example, by regulating neurotransmitter levels, regulating the neuroendocrine axis, improving neuroplasticity, anti-inflammatory and other effects, improving emotional state and play an antidepressant role. To provide evidence to support the widespread use of acupuncture in clinical practice. We hope to provide new treatment ideas and methods for patients with depression, and even reduce the incidence of depression.

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Intricate role of sleep deprivation in modulating depression: focusing on BDNF, VEGF, serotonin, cortisol, and TNF-α

Cited by 18 publications

References 277 publications

Curcumin inhibits expression of brain derived neurotrophic factor (BDNF) in hippocampus of mice with sleep deprivation

Curcumin inhibits expression of brain derived neurotrophic factor (BDNF) in hippocampus of mice with sleep deprivation

Repetitive transcranial magnetic stimulation in the treatment of middle-aged and elderly major depressive disorder: A randomized controlled trial

Treatment of Depression with Acupuncture Based on Pathophysiological Mechanism

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