“…A prominent finding is reduction of FC in the default mode network (DMN) [ 9 , 10 ], while other key findings include disruptions in emotional processing networks [ 11 ], executive network [ 12 ], salience network [ 13 ], and amygdala-DMN, as well as insula-hippocampus connectivity [ 14 ]. In accordance with these findings, our prior study also reported that childhood trauma, in the absence of psychiatric diagnosis, was associated with altered DMN, cerebellum-DMN, and insula-DMN connectivity, along with regional homogeneity (ReHo) changes in the inferior parietal lobule (IPL), superior temporal gyrus (STG), insula, cerebellum, and middle temporal gyrus [ 15 ]. Meanwhile, Philip et al (2013) used ReHo approach based on whole brain analysis and found a correlation of brain regional dysfunction in the IPL and STG with early life stress as well [ 16 ], suggesting that childhood trauma not only impacts FC but also brain regional activity.…”