Intrinsic brain activity changes associated with adjuvant chemotherapy in older women with breast cancer: a pilot longitudinal study

Chen, Bihong T.; Jin, Taihao; Patel, Sunita K.; Ye, Ningrong; Ma, Hui; Wong, Chi-Wah; Rockne, Russell C.; Root, James C.; Saykin, Andrew J.; Ahles, Tim A.; Holodny, Andrei I.; Prakash, Neal; Mortimer, Joanne; Waisman, James; Yuan, Yuan; Li, Daneng; Sedrak, Mina S.; Vázquez, Jessica; Katheria, Vani; Dale, William

doi:10.1007/s10549-019-05230-y

Cited by 27 publications

(26 citation statements)

References 40 publications

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“…We combined the static and dynamic brain activity changes to detect whether lung cancer patients with CTx had cognitive impairments by analyzing fMRI data. ALFF and ReHo often are used to measure static brain activity, and some previous studies have reported their use in cancer patients treated with CTx [31,32]. However, brain activity is inherently dynamic.…”

Section: Discussionmentioning

confidence: 99%

“…In our research, ALFF values of the patients after CTx displayed a significant decrease in the left precuneus compared with patients before CTx. Chen et al found that breast cancer patients after CTx displayed a significantly decreased fractional ALFF in the left precuneus compared with before CTx [32], which indicated CTx can make the intrinsic brain activity of the precuneus change. Our research again proved that the precuneus played a key place in brain changes after CTx.…”

Section: E921700-6mentioning

confidence: 99%

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Altered Dynamic Neural Activity in the Default Mode Network in Lung Cancer Patients After Chemotherapy

You

Zhang

et al. 2020

Med Sci Monit

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Background: Few studies have examined functional brain changes specifically associated with chemotherapy (CTx) in patients with lung cancer. This prospective longitudinal research aimed to explore the change in intrinsic brain activity by investigating patients with lung cancer after CTx. Material/Methods: Sixteen patients and 20 healthy individuals were enrolled in this study. The amplitude of low-frequency fluctuation (ALFF), regional homogeneity (ReHo), dynamic amplitude of low-frequency fluctuation (dALFF), and dynamic regional homogeneity (dReHo) were computed. The group differences in resting state functional magnetic resonance imaging (rs-fMRI) parameters were compared. Alterations in the rs-fMRI parameters from before CTx to after CTx were assessed using the paired t-test. We performed correlation analyses between rs-fMRI parameters and Montreal Cognitive Assessment (MoCA) scores. Results: We found statistically significant differences in MoCA scores before CTx and after CTx. Compared to the healthy group, rs-fMRI values decreased in the frontal regions as well as parietal regions compared to values before CTx. In addition, we found significantly decreased rs-fMRI values in the default-mode network (DMN) region of the brain before CTx compared to after CTx. We found no significant correlations between altered intrinsic activity values and MoCA scores. Conclusions: The current study indicated that patients with lung cancer after CTx had decreased dynamic brain activity in the DMN region, and the DMN is vulnerable when patients undergoing CTx.

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Section: Discussionmentioning

confidence: 99%

Section: E921700-6mentioning

confidence: 99%

Altered Dynamic Neural Activity in the Default Mode Network in Lung Cancer Patients After Chemotherapy

You

Zhang

et al. 2020

Med Sci Monit

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“…This research protocol also acquired additional neuroimaging data, including T1-weighted 3D, sagittal 3D fluid attenuated inversion recovery, susceptibility-weighted imaging, and resting-state functional MRI sequences, which were published previously [19][20][21][22]. However, data from DTI analysis of white matter microstructures has not yet been published.…”

Section: Study Assessmentmentioning

confidence: 99%

“…We reported NP testing scores obtained using the NIH Toolbox Cognition Battery for both the CT and HC groups in our previous publications [19][20][21][22]. However, since our previous studies, we added three patients to the CT group (n = 19).…”

Section: Np Datamentioning

confidence: 99%

Effects of chemotherapy on aging white matter microstructure: A longitudinal diffusion tensor imaging study

Chen

Wong

et al. 2020

Journal of Geriatric Oncology

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We aimed to use diffusion tensor imaging (DTI) to detect alterations in white matter microstructure in older patients with breast cancer receiving chemotherapy. Methods: We recruited women age ≥60 years with stage I-III breast cancer (chemotherapy [CT] group; n = 19) to undergo two study assessments: at baseline and within one month after chemotherapy. Each assessment consisted of a brain magnetic resonance imaging scan with DTI and neuropsychological (NP) testing using the National Institutes of Health (NIH) Toolbox Cognition Battery. An age-and sex-matched group of healthy controls (HC, n = 14) underwent the same assessments at matched intervals. Four DTI parameters (fractional anisotropy [FA], mean diffusivity [MD], axial diffusivity [AD], and radial diffusivity [RD]) were calculated and correlated with NP testing scores. Results: For CT group but not HCs, we detected statistically significant increases in MD and RD in the genu of the corpus callosum from time point 1 to time point 2 at p b 0.01, effect size:0.3655 and 0.3173, and 95% confidence interval: from 0.1490 to 0.5821, and from 0.1554 to 0.4792, for MD and RD respectively. AD values increased for the CT group and decreased for the HC group over time, resulting in significant between-group differences (p = 0.0056, effect size:1.0215, 95% confidence interval: from 0.2773 to 1.7657). There were no significant correlations between DTI parameters and NP scores (p N 0.05). Conclusions: We identified alterations in white matter microstructures in older women with breast cancer undergoing chemotherapy. These findings may potentially serve as neuroimaging biomarkers for identifying cognitive impairment in older adults with cancer.

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“…Most of the previous CRCI related rs-fMRI researches focused on a specific RSN alterations in breast cancer patients [22,23]. To the best of our knowledge, no studies have reported the dynamic changes of RSN functional connectivity in breast cancer survivors from a large-scale network perspective.…”

Section: Introductionmentioning

confidence: 99%

Aberrant Within- and Between-Network Connectivity in Chemotherapy Treated Breast Cancer Patients: A Longitudinal Resting State Functional MRI Study

Feng

Wang

Zheng

et al. 2020

Preprint

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Background Previous studies have found abnormal structural and functional brain alterations in breast cancer survivors undergoing chemotherapy. However, the network-level brain changes following chemotherapy remains unknown. The purpose of this study was to investigate the dynamic changes of large-scale intra- and inter- network functional connectivity in chemotherapy-treated breast cancer patients. Methods Eighteen breast cancer patients were evaluated with resting state functional MRI (rs-fMRI), neuropsychological tests and blood examination before postoperative chemotherapy (t0), one week after completing chemotherapy (t1) and six months after completing chemotherapy (t2). Nineteen age- and education level-matched healthy controls (HC) were also recruited. Independent component analysis (ICA) was performed to assess network component using rs-fMRI data. The functional network changes were then correlated with cognitive assessment scores and blood biochemical indexes. Results One-way repeated measures ANOVA revealed significantly changed within-network functional connectivity, which mainly located in the default mode network (DMN), frontoparietal network, visual network and self-referential network. Post-hoc test showed that most within-network functional connectivity decreased one week after chemotherapy and increased six months after chemotherapy. As for the between-network functional connectivity, the posterior DMN-SMN connectivity showed the same tendency. These within- and between-network functional connectivity changes were associated with blood biochemical indexes and cognitive assessment scores. Conclusions These results indicated that network-level connectivity alterations may serve as a potential biomarker of chemotherapy related cognitive impairment, providing insights for further functional recovery treatment.

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Intrinsic brain activity changes associated with adjuvant chemotherapy in older women with breast cancer: a pilot longitudinal study

Cited by 27 publications

References 40 publications

Altered Dynamic Neural Activity in the Default Mode Network in Lung Cancer Patients After Chemotherapy

Altered Dynamic Neural Activity in the Default Mode Network in Lung Cancer Patients After Chemotherapy

Effects of chemotherapy on aging white matter microstructure: A longitudinal diffusion tensor imaging study

Aberrant Within- and Between-Network Connectivity in Chemotherapy Treated Breast Cancer Patients: A Longitudinal Resting State Functional MRI Study

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