Intrinsic catalytic activity of Au nanoparticles with respect to hydrogen peroxide decomposition and superoxide scavenging

He, Weiwei; Zhou, Yuting; Wamer, Wayne G.; Hu, Xiaona; Wu, Xiaochun; Zheng, Zhi; Boudreau, Mary D.; Yin, Jun‐Jie

doi:10.1016/j.biomaterials.2012.10.010

Cited by 356 publications

(271 citation statements)

References 42 publications

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“…In addition, because ABTS Áþ , a semi-stable radical, can be directly identified from the magnetic parameters of the EPR spectrum, we used the EPR technique to study the peroxidase-like activity at high temperature. 41 In samples without ATP, the characteristic EPR spectra of the reaction solution were weak (Figure 2d). In contrast, strong EPR spectra for ABTS Áþ appeared upon the addition of ATP.…”

Section: Resultsmentioning

confidence: 99%

Incorporating ATP into biomimetic catalysts for realizing exceptional enzymatic performance over a broad temperature range

Lin

Ren

2014

NPG Asia Mater

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There has been great interest in the development of artificial inorganic nanomaterials that mimic natural peroxidases. Unfortunately, these nanomaterials usually possess relatively low catalytic activity and are generally considered to work effectively only within a narrow temperature range (for example, they are inactive at high temperatures). Intriguingly, adenosine triphosphate (ATP) is not only the ubiquitous energy currency of life, it is also known to form charge transfer complexes with aromatic molecules and to participate in free radical redox chemistry. Inspired by its unique properties, for the first time, we reveal a novel catalytic role for ATP and show that ATP is an ideal boosting agent for markedly improving the catalytic activity of a peroxidase mimic over a broad temperature range and, more significantly, making it possible to achieve exceptionally efficient high-temperature catalytic reactions. These observations pave the way for identifying highly effective modulators that promote the overall performance of artificial enzymes. NPG Asia Materials (2014) 6, e114; doi:10.1038/am.2014.42; published online 18 July 2014 INTRODUCTION Natural enzymes, which are biological molecules of immense catalytic force and high substrate specificity, have attracted considerable attention for use in pharmaceutical processes, agrochemical production, biosensing and food industry applications. 1-3 However, their applications are largely limited by their intrinsic properties, such as the sensitivity of catalytic activity to environmental conditions and low operational stability (owing to denaturation and digestion), as well as by the high costs of preparation and purification. 4,5 To circumvent the aforementioned limitations, tremendous efforts have been made to develop biomimetic catalysts. Among the countless examples of artificial enzymes, the emergence of and recent advances in nanotechnology and biology provide new opportunities for designing functional nanomaterials with enzyme-like characteristics. 4,[6][7][8] These materials might serve as novel and promising artificial enzymes with the advantages of facile preparation, tunability of catalytic activity and high stability under stringent conditions. Owing to the excellent catalytic properties of these nanomaterials, Scrimin and co-workers 7 called them 'nanozymes' in analogy to the nomenclature of catalytically active polymers (synzymes). Magnetic nanoparticles, 4,9 CeO 2 , 6,10-12 V 2 O 5 , 13,14 gold nanoparticles, 7,8,[15][16][17][18] PtPd ÀFe 3 O 4 , 19,20 carbon nanotubes, 21,22 graphene oxide and graphene nanocomposites 23,24 and other types of nanoparticle have been found to exhibit unique enzyme-like catalytic activities and have

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Section: Resultsmentioning

confidence: 99%

Incorporating ATP into biomimetic catalysts for realizing exceptional enzymatic performance over a broad temperature range

Lin

Ren

2014

NPG Asia Mater

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“…The catalytic properties of metals could also directly increment the oxidative chain reactions. The gold nanoparticles rapidly catalyze the decomposition of hydrogen peroxide, leading to the formation of hydroxyl radicals that in turn caused excessive oxidation damage (He et al, 2013).Toxicity of AgNPs was decreased by the antioxidants; that also proved major role of oxidation as the main mechanism (Kim et al, 2011).The molecular way of this mechanism include the disruption of the mitochondrial respiratory chain leading to the production of reactive oxygen species and the interruption of ATP synthesis in cells (AshaRani et al, 2009).However, one study shows the results of much higher toxicity of silver compared with gold in vivo for zebrafish embryos, meaning that the revealed DNA damage is not a main factor of overall biotoxicity of silver (Bar-Ilan et al, 2009).In this regard, it is important to take into account the particle size. The bio impact of nanoparticles is highly size-dependent (Barar, 2015).…”

Section: Discussionmentioning

confidence: 99%

Comparative Study of Genotoxicity of Silver and Gold Nanoparticles Prepared by the Electric Spark Dispersion Method

2017

J App Pharm Sci

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Objective: There is plenty of information dedicated to nanomaterial toxicity, but it is often contradictory. This work presents results of the comparative investigation of silver and gold nanoparticles genotoxicity and genotoxic effect of water medium after the spark dispersion process. Material and methods:The nanoparticles were produced in water by the modified energy-efficient electric spark dispersion method. The comet assay, transmission electron microscopy, DLS spectroscopy and thermal desorption of nitrogen (BET method) were used for the investigation. Results:The silver nanoparticles showed a genotoxic effect which appeared at concentration of 0.03 mg/ml and above. The application of gold nanoparticles did not lead to a significant DNA damage at concentrations range of 0.01 -0.03 mg/ml. However, a notable level of genotoxicity was observed at concentrations of gold nanoparticles about 0.1 mg/ml. Supernatant water medium (with trace of Au and Ag metals) following the spark dispersion process showed no genotoxic action. Conclusion: Accordingly, the testing of the nanoparticles produced by the electric spark dispersion in water revealed more expressed genotoxic effect of silver nanoparticles in comparison with the gold ones.

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“…According to ESR spectroscopy measurements [27] AuNPs generate reactive oxygen species along with formation of hydroxyl radicals at lower and evolution of O 2 at higher pHs.…”

Section: Catalytic Activity Of Zno/pvp-aunps In Decomposition Of Hydrmentioning

confidence: 99%

“…Recent advances in NPs as enzyme mimetics and their analytical and environmental applications are reviewed in [26]. Authors [27] reported that AuNPs can catalyze rapid decomposition of hydrogen peroxide. It is demonstrated that AuNPs can act as superoxide dismutase (SOD) and catalase mimetics.…”

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confidence: 99%

Catalytic Activity of Gold and Silver Nanoparticles Supported on Zinc Oxide

Yesmurzayeva¹,

Nurakhmetova²,

Tatykhanova³

et al. 2015

Supramolecular Catalysis

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Gold (AuNPs) and silver (AgNPs) nanoparticles have been prepared by “one-pot” synthetic method in the presence of poly(N-vinylpyrrolidone) (PVP). Absorption spectra, size, morphology, and structure of AuNPs and AgNPs were studied by UV-Vis spectroscopy, DLS, SEM, and TEM. According to DLS measurements the average sizes of metal nanoparticles stabilized by PVP in aqueous solution are varied from 10 to 25 nm for AuNPs and from 6.5 to 44 nm for AgNPs. The impregnation method is used to support AuNPs and AgNPs on the surface of ZnO. The amount of AuNPs and AgNPs immobilized on the surface of ZnO does not exceed 0.2 wt.%. The catalytic activity of AuNPs and AgNPs supported on the surface of ZnO was evaluated with respect to decomposition of hydrogen peroxide. The optimal conditions for H2O2 decomposition were found to be dependent on of the amount of the catalyst, concentration of substrate, molecular weight of PVP, and temperature. The activation energy of H2O2 decomposition is equal to 44.1 kJ×mol-1. The decomposition of H2O2 in the presence of AuNPs and AgNPs supported on ZnO surface is discussed in the context of supramolecular catalysis mimicking catalase-like behavior. The recyclability of AuNPs supported on ZnO surface was tested.

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Intrinsic catalytic activity of Au nanoparticles with respect to hydrogen peroxide decomposition and superoxide scavenging

Cited by 356 publications

References 42 publications

Incorporating ATP into biomimetic catalysts for realizing exceptional enzymatic performance over a broad temperature range

Incorporating ATP into biomimetic catalysts for realizing exceptional enzymatic performance over a broad temperature range

Comparative Study of Genotoxicity of Silver and Gold Nanoparticles Prepared by the Electric Spark Dispersion Method

Catalytic Activity of Gold and Silver Nanoparticles Supported on Zinc Oxide

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