Intrinsic Connectivity Networks in the Self- and Other-Referential Processing

Knyazev, Gennady G.; Savostyanov, Alexander N.; Bocharov, Andrey V.; Levin, E. A.; Rudych, P. D.

doi:10.3389/fnhum.2020.579703

Cited by 19 publications

(15 citation statements)

References 103 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In this study, we used the data, which have already been described in the previous studies (Knyazev et al, 2020a , b ) but have been reanalyzed here in a completely different way. Fifty undergraduate and postgraduate students and staff members participated in the study.…”

Section: Methodsmentioning

confidence: 99%

How Self-Appraisal Is Mediated by the Brain

Knyazev¹,

Savostyanov

Bocharov

et al. 2021

Front. Hum. Neurosci.

Self Cite

View full text Add to dashboard Cite

Self-appraisal is a process that leads to the formation of self-esteem, which contributes to subjective well-being and mental health. Neuroimaging studies link self-esteem with the activity of the medial prefrontal cortex (MPFC), right temporoparietal junction (rTPJ), posterior cingulate cortex (PCC), anterior insula (AIns), and dorsolateral prefrontal cortex. It is not known, however, how the process of self-appraisal itself is mediated by the brain and how different nodes of the self-appraisal network interact with each other. In this study, we used multilevel mediation analysis of functional MRI data recorded during the trait adjective judgment task, treating the emotional valence of adjectives as the predictor, behavioral response as the dependent variable, and brain activity as the mediator. The mediation effect was revealed in the rTPJ. Dynamic causal modeling showed that positive self-descriptions trigger communication within the network, with the rTPJ exerting the strongest excitatory output and MPFC receiving the strongest excitatory input. rAIns receives the strongest inhibitory input and sends exclusively inhibitory connections to other regions pointing out to its role in the processing of negative self-descriptions. Analysis of individual differences showed that in some individuals, self-appraisal is mostly driven by the endorsement of positive self-descriptions and is accompanied by increased activation and communication between rTPJ, MPFC, and PCC. In others, self-appraisal is driven by the rejection of negative self-descriptions and is accompanied by increased activation of rAIns and inhibition of PCC and MPFC. Membership of these groups was predicted by different personality variables. This evidence uncovers different mechanisms of positive self-bias, which may contribute to different facets of self-esteem and are associated with different personality profiles.

show abstract

Section: Methodsmentioning

confidence: 99%

How Self-Appraisal Is Mediated by the Brain

Knyazev¹,

Savostyanov

Bocharov

et al. 2021

Front. Hum. Neurosci.

Self Cite

View full text Add to dashboard Cite

show abstract

“…One of the higher-order brain networks modulated by psychedelics that has gained attention in recent years is the DMN, associated with a range of experiences and conditions (284), including but not limited to self-reflection and rumination (13,120,265,285,286) and meta-cognitive processes (287). Alterations in DMN rsFC have been demonstrated across a range of disorders.…”

Section: Neural Circuitrymentioning

confidence: 99%

Psychedelic Therapy's Transdiagnostic Effects: A Research Domain Criteria (RDoC) Perspective

et al. 2021

View full text Add to dashboard Cite

Accumulating clinical evidence shows that psychedelic therapy, by synergistically combining psychopharmacology and psychological support, offers a promising transdiagnostic treatment strategy for a range of disorders with restricted and/or maladaptive habitual patterns of emotion, cognition and behavior, notably, depression (MDD), treatment resistant depression (TRD) and addiction disorders, but perhaps also anxiety disorders, obsessive-compulsive disorder (OCD), Post-Traumatic Stress Disorder (PTSD) and eating disorders. Despite the emergent transdiagnostic evidence, the specific clinical dimensions that psychedelics are efficacious for, and associated underlying neurobiological pathways, remain to be well-characterized. To this end, this review focuses on pre-clinical and clinical evidence of the acute and sustained therapeutic potential of psychedelic therapy in the context of a transdiagnostic dimensional systems framework. Focusing on the Research Domain Criteria (RDoC) as a template, we will describe the multimodal mechanisms underlying the transdiagnostic therapeutic effects of psychedelic therapy, traversing molecular, cellular and network levels. These levels will be mapped to the RDoC constructs of negative and positive valence systems, arousal regulation, social processing, cognitive and sensorimotor systems. In summarizing this literature and framing it transdiagnostically, we hope we can assist the field in moving toward a mechanistic understanding of how psychedelics work for patients and eventually toward a precise-personalized psychedelic therapy paradigm.

show abstract

“…Multiple studies [ 46 , 47 , 48 , 49 , 50 , 51 , 52 , 53 ] have linked the DMN to self-mentalizing abilities, which is why we investigated FC values of CMS specifically to the lateral DMN in patients and controls. Emanating from observations in early functional imaging studies of functional activity of DMN regions, mainly in the resting condition [ 54 , 55 , 56 ], the DMN has been related to mind wandering, introspection, and self-relatedness [ 46 , 47 ].…”

Section: Discussionmentioning

confidence: 99%

Self-Referential Processing and Resting-State Functional MRI Connectivity of Cortical Midline Structures in Glioma Patients

Jütten

Forster

et al. 2022

Brain Sciences

View full text Add to dashboard Cite

Metacognition has only scarcely been investigated in brain tumor patients. It is unclear if and how the tumor-lesioned brain might be able to maintain an adequate sense-of-self. As cortical midline structures (CMS) are regarded as essential for self-referential mental activity, we investigated resting-state fMRI connectivity (FC) of CMS to the default-mode network (DMN) and to the whole brain, comparing glioma patients and matched controls. Subjects furthermore performed a trait judgement (TJ), a trait recall task (TR), and neuropsychological testing. In the TJ, adjectives had to be ascribed as self- or non-self-describing, assessing the self-serving effect (SSE), a normally observed bias for positive traits. In the TR, the mnemic neglect effect (MNE), a memory advantage for positive traits, was tested. The groups were compared and partial correlations between FC and test metrics were analyzed. Although patients were significantly impaired in terms of verbal memory, groups did not differ in the SSE or the MNE results, showing preserved metacognitive abilities in patients. FC of CMS to the DMN was maintained, but was significantly decreased to whole brain in the patients. FC of the dorsomedial prefrontal cortex (DMPFC) to whole brain was correlated with the MNE in patients. Preserving the DMPFC in therapeutic interventions might be relevant for maintaining self-related verbal information processing in the memory domain in glioma patients.

show abstract

Intrinsic Connectivity Networks in the Self- and Other-Referential Processing

Cited by 19 publications

References 103 publications

How Self-Appraisal Is Mediated by the Brain

How Self-Appraisal Is Mediated by the Brain

Psychedelic Therapy's Transdiagnostic Effects: A Research Domain Criteria (RDoC) Perspective

Self-Referential Processing and Resting-State Functional MRI Connectivity of Cortical Midline Structures in Glioma Patients

Contact Info

Product

Resources

About