Intrinsic drug potential of oxazolo[5,4‐d]pyrimidines and oxazolo[4,5‐d]pyrimidines

Abstract

The oxazole and pyrimidine rings are widely displayed in natural products and synthetic molecules. They are known as the prime skeletons for drug discovery. On the account of structural and chemical diversity, oxazole and pyrimidine-based molecules, as central scaffolds, not only provide different types of interactions with various receptors and enzymes, showing broad biological activities, but also oc-How to cite this article:

Design, synthesis and evaluation of the anti-breast cancer activity of 1,3-oxazolo[4,5-d]pyrimidine and 1,3-oxazolo[5,4-d]pyrimidine derivatives

“…So far, the synthesized 1,3-oxazole derivatives have shown high anticancer activity through interactions with various cellular targets, resulting in both delayed proliferation and the death of cancer cells. [3][4][5][6] Taken together, 1,3-oxazole holds a promising background for the development of new drugs against cancer cells.…”

Synthesis, Characterization and in vitro Anticancer Evaluation of 5‐Sulfinyl(sulfonyl)‐4‐arylsulfonyl‐Substituted 1,3‐Oxazoles

“…Due to the structural and chemical diversity of molecules synthesized from 1,3-oxazole and, consequently, their ability to interact with different molecular targets of the cell, 1,3-oxazole derivatives occupy one of the central position in medicinal chemistry. [1][2][3] This is reflected in the manifestation of their broad biological activity and demonstrates the massive potential of such derivatives in the discovery of new potential therapeutic agents. [4,5] This is confirmed by the wide variety of oxazole-containing compounds used as therapeutic drugs, presented in DrugBank (https://go.drugbank.com/), which are actively used throughout the world.…”

Synthesis of some oxazolo[4,5 d]pyrimidine derivatives and evaluation of their antiviral activity and cytotoxicity

“…1 However, it seems that oxazolo [4,5-d]pyrimidines have only been synthesized, and that there is little information in the literature concerning their bioactivity. 2 Among these bioactivity reports, inhibition of fatty acid amide hydrolase and monoglyceride lipase 3 by these compounds have been described. Some of oxazolo [4,5-d]pyrimidine derivatives were also shown to exhibit anticancer activity.…”