Intrinsic mesocorticolimbic connectivity is negatively associated with social amotivation in people with schizophrenia

Xu, Pengfei; Klaasen, Nicky; Opmeer, Esther M.; Pijnenborg, Gerdina; Tol, Marie-José van; Liemburg, Edith J.; Alemán, André

doi:10.1016/j.schres.2019.01.023

Cited by 21 publications

(27 citation statements)

References 54 publications

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“…Additionally, the extent of the impairment within the striatum-OFC was dependent on negative symptom severity. This finding was replicated in a cohort study of 84 schizophrenia patients, where VTA-OFC connectivity was negatively associated with social amotivation (Xu et al, 2019). Together, this evidence suggests that negative symptoms in schizophrenia patients are associated with reduced functional activation during reward anticipation as well as altered functional connectivity within the fronto-striatal network.…”

Section: Neural Correlates Of Reward Processing In Schizophreniamentioning

confidence: 61%

“…Adapted from Figure 5 in Pessiglione et al (2018). (Walter et al, 2009;Dowd and Barch, 2012;Arrondo et al, 2015;Subramaniam et al, 2015;Moran et al, 2019;Shukla et al, 2019;Xu et al, 2019). Neural activation, inferred from blood oxygen level dependent (BOLD) signals, was compared between patients and healthy controls while performing various reinforcement learning paradigms (Walter et al, 2009;Dowd and Barch, 2012;Arrondo et al, 2015;Subramaniam et al, 2015).…”

Section: Neural Correlates Of Reward Processing In Schizophreniamentioning

confidence: 99%

“…For example, two earlier experiments demonstrated that reduced VS activation during reward anticipation was only associated with anhedonia, and not other components of the negative syndrome (Dowd and Barch, 2012;Arrondo et al, 2015). Functional connectivity has also been assessed in schizophrenia (Shukla et al, 2019;Xu et al, 2019). This involves voxel-wise correlation of BOLD signal time series between spatially distributed brain areas (Shukla et al, 2019;Xu et al, 2019).…”

Section: Neural Correlates Of Reward Processing In Schizophreniamentioning

confidence: 99%

“…Functional connectivity has also been assessed in schizophrenia (Shukla et al, 2019;Xu et al, 2019). This involves voxel-wise correlation of BOLD signal time series between spatially distributed brain areas (Shukla et al, 2019;Xu et al, 2019). The assumption is that regions that show high similarity in BOLD signal are likely to be functionally connected (Woodward and Cascio, 2015).…”

Section: Neural Correlates Of Reward Processing In Schizophreniamentioning

confidence: 99%

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Mechanisms Underlying Motivational Dysfunction in Schizophrenia

Saleh

Jarratt-Barnham

Fernández-Egea

2021

Front. Behav. Neurosci.

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Negative symptoms are a debilitating feature of schizophrenia which are often resistant to pharmacological intervention. The mechanisms underlying them remain poorly understood, and diagnostic methods rely on phenotyping through validated questionnaires. Deeper endo-phenotyping is likely to be necessary in order to improve current understanding. In the last decade, valuable behavioural insights have been gained through the use of effort-based decision making (EBDM) tasks. These have highlighted impairments in reward-related processing in schizophrenia, particularly associated with negative symptom severity. Neuroimaging investigations have related these changes to dysfunction within specific brain networks including the ventral striatum (VS) and frontal brain regions. Here, we review the behavioural and neural evidence associated with negative symptoms, shedding light on potential underlying mechanisms and future therapeutic possibilities. Findings in the literature suggest that schizophrenia is characterised by impaired reward based learning and action selection, despite preserved hedonic responses. Associations between amotivation and reward-processing deficits have not always been clear, and may be mediated by factors including cognitive dysfunction or dysfunctional or self-defeatist beliefs. Successful endo-phenotyping of negative symptoms as a function of objective behavioural and neural measurements is crucial in advancing our understanding of this complex syndrome. Additionally, transdiagnostic research–leveraging findings from other brain disorders, including neurological ones–can shed valuable light on the possible common origins of motivation disorders across diseases and has important implications for future treatment development.

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Section: Neural Correlates Of Reward Processing In Schizophreniamentioning

confidence: 61%

Section: Neural Correlates Of Reward Processing In Schizophreniamentioning

confidence: 99%

Section: Neural Correlates Of Reward Processing In Schizophreniamentioning

confidence: 99%

Section: Neural Correlates Of Reward Processing In Schizophreniamentioning

confidence: 99%

See 2 more Smart Citations

Mechanisms Underlying Motivational Dysfunction in Schizophrenia

Saleh

Jarratt-Barnham

Fernández-Egea

2021

Front. Behav. Neurosci.

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“…This is supported by studies reporting salience misattribution in CHR-P individuals (Addington et al, 2008;Amminger et al, 2012;Dickson et al, 2014;Kohler et al, 2014;Roddy et al, 2012;van Rijn et al, 2011). As dopamine seems to be involved in all key processes underpinning the interaction of emotion and cognitive control at the brain level (PFC, amygdala and striatum), it is likely that alterations in the mesocorticolimbic dopamine pathways play a critical role in the dysfunctional emotion-cognitive control interaction in psychosis (Mueller, 2011;Xu et al, 2019). However, this hypothesis warrants further investigation.…”

Section: Affect Emotion-cognitive Control Interaction and Psychosismentioning

confidence: 99%

Interaction of emotion and cognitive control along the psychosis continuum: A critical review

Duggirala

Schwartze

Pinheiro

et al. 2020

International Journal of Psychophysiology

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Brain activity and connectivity differences in reward value discrimination during effort computation in schizophrenia

Bavel

Bergé

Guell

et al. 2020

Eur Arch Psychiatry Clin Neurosci

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Intrinsic mesocorticolimbic connectivity is negatively associated with social amotivation in people with schizophrenia

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Cited by 21 publications

References 54 publications

Mechanisms Underlying Motivational Dysfunction in Schizophrenia

Mechanisms Underlying Motivational Dysfunction in Schizophrenia

Interaction of emotion and cognitive control along the psychosis continuum: A critical review

Brain activity and connectivity differences in reward value discrimination during effort computation in schizophrenia

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