Intrinsic neuroendocrine cells in the outer wall of the human pyriform recess

Şelaru, Mircea; Hostiuc, Sorin; Rusu, Mugurel Constantin

doi:10.1007/s12565-014-0256-8

Cited by 2 publications

(1 citation statement)

References 19 publications

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“…Neuron‐specific gamma‐enolase is both a neural and a neuroendocrine cytosolic marker and is not related to secretory granules (Marangos and Schmechel, ; Nadri et al, ; Selaru et al, ). It is unclear why spindle‐shaped TC‐like cells express NSE within lung tissues or why TCs are labeled with NSE.…”

Section: Introductionmentioning

confidence: 99%

Critical Review: What Cell Types Are the Lung Telocytes?

Rusu

Hostiuc

Fildan

et al. 2019

The Anatomical Record

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Telocytes (TCs) are stromal cells defined by peculiar long, thin, moniliform prolongations known as telopodes. When isolated, their morphology often lacks the specificity for the proper definition of a particular cell type. Recent studies have linked TCs with different functions and different cell lineages. Although some authors have studied pulmonary TCs, their research has important limitations that we will attempt to summarize in this article. We will focus our analysis on the following: the culture methods used to study them, the lack of proper discrimination of TCs from lymphatic endothelial cells (LECs), whose ultrastructures are very similar, and the immune phenotype of TCs, which may appear in other cell types such as those related to the endothelial lineage or stem/progenitor cells. In conclusion, the cellular diagnosis of lung TCs should be considered with caution until properly designed studies can positively identify these cells and differentiate them from other cell types such as LECs and stem/progenitor cells.Abbreviations list: BEC = blood endothelial cell; EC = endothelial cell; ICC = interstitial Cajal cell; ICLC = interstitial Cajal-like cell; IHC = immunohistochemistry; LEC = lymphatic endothelial cell; MSC = mesenchymal stem cell; NSE = neuron-specific enolase; PDGF = platelet-derived growth factor; PDGFR = plateletderived growth factor receptor; TC = telocyte; TEM = transmission electron microscopy; Tps = telopodes; VEGF = vascular endothelial growth factor; VEGFR = vascular endothelial growth factor receptor *Correspondence to: Ariadna P. Fildan

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Section: Introductionmentioning

confidence: 99%

Critical Review: What Cell Types Are the Lung Telocytes?

Rusu

Hostiuc

Fildan

et al. 2019

The Anatomical Record

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Expression of nNOS in the human larynx

2015

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Although intrinsic laryngeal neurons and ganglia have been studied in various species, they have been overlooked in humans. We aimed to investigate the presence of intrinsic laryngeal neurons in humans and, if present, to analyze their neuronal nitric oxide synthase (nNOS) expression. An immunohistochemical study using anti-nNOS antibodies was performed on samples obtained from four cadavers. Intrinsic laryngeal nNOS+ neurons were assessed in the submucosal layer, but nNOS+ nerves were found in all histological layers of the larynx. nNOS expression was also found in striated muscle fibers of larynx. This might reveal the anatomical basis of an upwards extension of the nonadrenergic noncholinergic system in human airways, but further experiments are needed to assess an exact role of NO influence on neural transmission and muscular functions of human larynx.

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Intrinsic neuroendocrine cells in the outer wall of the human pyriform recess

Cited by 2 publications

References 19 publications

Critical Review: What Cell Types Are the Lung Telocytes?

Critical Review: What Cell Types Are the Lung Telocytes?

Expression of nNOS in the human larynx

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