Intrinsic superoxide dismutase activity of MnO nanoparticles enhances the magnetic resonance imaging contrast

Ragg, Ruben; Schilmann, Anna-Maria; Korschelt, Karsten; Wieseotte, C.; Kluenker, Martin; Viel, Melanie; Völker, L.; Preiß, Sebastian; Herzberger, Jana; Frey, Holger; Heinze, Katja; Blümler, Peter; Tahir, Muhammad Nawaz; Natálio, Filipe; Tremel, Wolfgang

doi:10.1039/c6tb02078j

Cited by 82 publications

(45 citation statements)

References 46 publications

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“…The development of nanocatalytic medicine has facilitated the emergence of various catalytic agents for enhancing MR contrast, by initiating in situ catalytic reactions and triggering paramagnetism elevation without toxic ions leakage, thus achieving simultaneously enhanced diagnostic efficacy, widened time windows, reduced administration dosage, and mitigated side effect. Ragg et al first demonstrated that MnO nanoparticles with dual enzyme‐like activities could act as efficient MR contrast agents in cancer diagnosis ( Figure ) . The SOD‐like activity of MnO nanoparticles enables catalytic decomposition of intratumoral O 2 •− into H 2 O 2 , as illustrated in the following equations:

{normalO}_{2}^{• -} + {Mn}^{2 +} + 2 {normalH}^{+} \to {normalH}_{normal2} {normalO}_{2} + {Mn}^{3 +}

{normalO}_{2}^{• -} + {Mn}^{3 +} \to {normalO}_{2} + {Mn}^{2 +}

…”

Section: Nanocatalytic Medicine For Diagnostic Applicationsmentioning

confidence: 99%

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Nanocatalytic Medicine

2019

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Catalysis and medicine are often considered as two independent research fields with their own respective scientific phenomena. Promoted by recent advances in nanochemistry, large numbers of nanocatalysts, such as nanozymes, photocatalysts, and electrocatalysts, have been applied in vivo to initiate catalytic reactions and modulate biological microenvironments for generating therapeutic effects. The rapid growth of research in biomedical applications of nanocatalysts has led to the concept of “nanocatalytic medicine,” which is expected to promote the further advance of such a subdiscipline in nanomedicine. The high efficiency and selectivity of catalysis that chemists strived to achieve in the past century can be ingeniously translated into high efficacy and mitigated side effects in theranostics by using “nanocatalytic medicine” to steer catalytic reactions for optimized therapeutic outcomes. Here, the rationale behind the construction of nanocatalytic medicine is eludicated based on the essential reaction factors of catalytic reactions (catalysts, energy input, and reactant). Recent advances in this burgeoning field are then comprehensively presented and the mechanisms by which catalytic nanosystems are conferred with theranostic functions are discussed in detail. It is believed that such an emerging catalytic therapeutic modality will play a more important role in the field of nanomedicine.

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{normalO}_{2}^{• -} + {Mn}^{2 +} + 2 {normalH}^{+} \to {normalH}_{normal2} {normalO}_{2} + {Mn}^{3 +}

{normalO}_{2}^{• -} + {Mn}^{3 +} \to {normalO}_{2} + {Mn}^{2 +}

…”

Section: Nanocatalytic Medicine For Diagnostic Applicationsmentioning

confidence: 99%

Section: Nanocatalytic Medicine For Diagnostic Applicationsmentioning

confidence: 99%

Nanocatalytic Medicine

2019

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“…By analyzing the corresponding fluorescence intensity, the distribution of glucose in cancer cells could be mapped. [30c] The MnO‐based nanosystem with selective response toward superoxide radicals is capable of enhancing the magnetic resonance (MR) imaging contrast by sequential catalytic reaction . Based on the catalase‐like activity of MnO 2 toward H 2 O 2 , the in situ oxygen generation and upconversion luminescent imaging can be achieved simultaneously, which is capable of achieving the desirable cancer theranostics via the oxygen‐elevated synergetic radio/photodynamic therapy (PDT) .…”

Section: Applications Of Nanozymesmentioning

confidence: 99%

Recent Advances in Nanozyme Research

2018

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inflammatory response to combat infections and can also react with many important biomolecules including proteins, lipids, and nucleic acid polymers (RNA and DNA). [7] Low dosage of ROS plays important roles in signal transduction, cell proliferation/migration/differentiation, and body defense against pathogen invasion. However, abnormally elevated ROS level can destroy redox homeostasis and cause oxidative stress and serious damage of structure and function of macromolecules in the cell. Research during the last decade has shown that oxidative stress could lead to diseases such as chronic inflammation and eventually diabetes, cancer, as well as cardiovascular, neurological, and pulmonary diseases. [8] Enzyme systems (e.g., superoxide dismutase (SOD), glutathione peroxidase (GPx), and catalase) are responsible for protecting cells from the detrimental effects of ROS by modulating the intracellular ROS level.Nanozyme can also modulate the ROS level in cells (Figure 2). [9] The ROS scavenging abilities of nanozymes largely originate from the SOD mimicking activities, which convert superoxide into H 2 O 2 and subsequently to O 2 and H 2 O, and thus reduce the intracellular ROS level and enhance cell viability. The generation of ROS originates from their peroxidases (POD) activities, which convert H 2 O 2 to OH· radicals, and oxidase activities, which convert O 2 to H 2 O 2 . Outside the cell, ROS can react with biologically active molecules (such as glucose, dopamine, glutathione, and adenosine triphosphate), organic compound (such as phenol and dyes), and pollutants from aqueous solutions. Thus the nanozymes could play important roles in in vitro test and environmental protection. [10] Earlier reports on nanozymes mainly focused on the aspect of experimental study and rarely focused on the theoretical work and mechanism clarification. In this progress report, we first introduce various nanozymes and highlight recent experimental development of new nanozymes that have been investigated to mimic various enzymes. Then we review their applications in various fields including biosensing, bioimaging, therapeutics, and environmental protection. At last, we summarize the catalytic mechanisms and address the challenges of experimental and computational research in this field. The Structure of NanozymesIssues of material design for high catalytical activity, selectivity, and durability are recently accentuated. Among them As a new generation of artificial enzymes, nanozymes have the advantages of high catalytic activity, good stability, low cost, and other unique properties of nanomaterials. Due to their wide range of potential applications, they have become an emerging field bridging nanotechnology and biology, attracting researchers in various fields to design and synthesize highly catalytically active nanozymes. However, the thorough understanding of experimental phenomena and the mechanisms beneath practical applications of nanozymes limits their rapid development. Herein, the progress of experimental and computational...

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“…Nanozymes have increasingly attracted significant interest since we first uncovered the intrinsic peroxidase‐like activity of Fe 3 O 4 nanoparticles (NPs) in 2007. [ 3 ] Up to now, there are hundreds of nanomaterials that have been found to mimic the catalytic activity of peroxidases, [ 4,5 ] oxidase, [ 6 ] catalase, [ 7 ] haloperoxidase, [ 8,9 ] monooxygenase, [ 10 ] hydrolase, [ 11,12 ] superoxide dismutase, [ 13,14 ] or multienzyme systems. [ 15,16 ] Along with the rapid development and deepening understanding of nanoscience and nanotechnology, nanozymes hold promise to serve as direct surrogates of traditional enzymes.…”

Section: Introductionmentioning

confidence: 99%

Peroxidase‐Like Nanozymes Induce a Novel Form of Cell Death and Inhibit Tumor Growth In Vivo

Wang

Liu

et al. 2020

Adv Funct Materials

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Nanomaterials with intrinsic enzyme-like properties, termed nanozymes, have attracted significant interest, although limited information is available on their biological characteristics in cells or in vivo. Here, it is shown that nanomaterials with peroxidase-like activity trigger a novel form of cell death through an ATP-citrate lyase (ACLY)-dependent rat sarcoma viral oncogene (RAS) signaling mechanism. The peroxidase nanozyme-induced cell lethality, which is termed as nanoptosis, is morphologically and biochemically distinct from the currently well-defined apoptosis, necrosis, autophagy, pyroptosis, and ferroptosis. It is revealed that nanoptosis is typically characterized by the massive accumulation of cellular vesicles, swelling mitochondria, and distinct chromatin condensation and margination. Using RNA sequencing and protein quantitative mass spectrometry, an ACLY-dependent RAS signaling pathway is identified that mainly mediates this nanozyme lethality process, and it is observed that RAS-knockout cells are highly resistant to nanoptosis. Finally, it is demonstrated that this newly discovered nanozyme lethality can be used as an effective therapeutic strategy for inhibiting tumor growth in vivo.

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Intrinsic superoxide dismutase activity of MnO nanoparticles enhances the magnetic resonance imaging contrast

Abstract: MnO nanoparticles decompose superoxide and hydrogen peroxide in an enzyme-like manner leading to enhanced MRI contrast.

Cited by 82 publications

References 46 publications

Nanocatalytic Medicine

Nanocatalytic Medicine

Recent Advances in Nanozyme Research

Peroxidase‐Like Nanozymes Induce a Novel Form of Cell Death and Inhibit Tumor Growth In Vivo

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