The heat accumulation effect associated with heat dispersion process in phase change memory cell was analyzed. The pulse operating scheme was optimized. The pulse sequences with different intervals show distinct heat accumulation effect. A compact model with pulse sequence expansion was proposed, and the simulation result is close to the experiment data for a pulse sequence with interval 20 ns. The simulated R-V curves show that threshold voltage reduces with the decreasing pulse interval. The secondary crystallization and amorphization were used to explain the heat accumulation effect for high speed operation, cycling, and so on.