Intrinsic values of procalcitonin in bacterial bloodstream infections in people aged 75 years and over: a retrospective study

Gavazzi, G.; Meyrignac, L.; Zerhouni, Nabil; Bioteau, Catherine; López, Clara; François, Patrice; Drevet, Sabine

doi:10.1016/j.diagmicrobio.2022.115887

Cited by 3 publications

(2 citation statements)

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“…Serum procalcitonin (PCT) is a valuable biomarker for bacterial infections and sepsis prognosis [59][60][61][62]. It can be applied in older patients using similar cutoff values as in younger patients [63] demonstrating comparable performance and higher diagnostic accuracy than Fig.…”

Section: Diagnosis Of Sepsismentioning

confidence: 99%

The critically ill older patient with sepsis: a narrative review

Ibarz,

Haas,

Ceccato

et al. 2024

Ann. Intensive Care

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Sepsis is a significant public health concern, particularly affecting individuals above 70 years in developed countries. This is a crucial fact due to the increasing aging population, their heightened vulnerability to sepsis, and the associated high mortality rates. However, the morbidity and long-term outcomes are even more notable. While many patients respond well to timely and appropriate interventions, it is imperative to enhance efforts in identifying, documenting, preventing, and treating sepsis. Managing sepsis in older patients poses greater challenges and necessitates a comprehensive understanding of predisposing factors and a heightened suspicion for diagnosing infections and assessing the risk of sudden deterioration into sepsis. Despite age often being considered an independent risk factor for mortality and morbidity, recent research emphasizes the pivotal roles of frailty, disease severity, and comorbid conditions in influencing health outcomes. In addition, it is important to inquire about the patient's preferences and establish a personalized treatment plan that considers their potential for recovery with quality of life and functional outcomes. This review provides a summary of the most crucial aspects to consider when dealing with an old critically ill patient with sepsis.

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Section: Diagnosis Of Sepsismentioning

confidence: 99%

The critically ill older patient with sepsis: a narrative review

Ibarz,

Haas,

Ceccato

et al. 2024

Ann. Intensive Care

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“…In this tudy, antibiotic therapy exposure was reduced in the PCT group as compared to the Control group from a median of 8–10 days with no significant difference in recovery rate. Also, several studies indicated that PCT was superior to other markers regarding diagnosis, prediction of bacteremia and prediction of mortality [ 92 – 95 ]. A meta-analysis including four studies showed that the area under the curve (AUC) was 0.89 (95%CI 0.86–0.92) for identifying systemic bacterial infections in elderly patients [ 96 ].…”

Section: Treatment Studies In Respiratory Tract Infectionmentioning

confidence: 99%

Biomarkers for risk stratification and antibiotic stewardship in elderly patients

Falcone¹,

Bauer

Ferrer

et al. 2023

Aging Clin Exp Res

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Purpose Optimal treatment of infections in the elderly patients population is challenging because clinical symptoms and signs may be less specific potentially resulting in both, over- and undertreatment. Elderly patients also have a less pronounced immune response to infection, which may influence kinetics of biomarkers of infection. Methods Within a group of experts, we critically reviewed the current literature regarding biomarkers for risk stratification and antibiotic stewardship in elderly patients with emphasis on procalcitonin (PCT). Results The expert group agreed that there is strong evidence that the elderly patient population is particularly vulnerable for infections and due to ambiguity of clinical signs and parameters in the elderly, there is considerable risk for undertreatment. At the same time, however, this group of patients is particularly vulnerable for off-target effects from antibiotic treatment and limiting the use of antibiotics is therefore important. The use of infection markers including PCT to guide individual treatment decisions has thus particular appeal in geriatric patients. For the elderly, there is evidence that PCT is a valuable biomarker for assessing the risk of septic complications and adverse outcomes, and helpful for guiding individual decisions for or against antibiotic treatment. There is need for additional educational efforts regarding the concept of “biomarker-guided antibiotic stewardship” for health care providers caring for elderly patients. Conclusion Use of biomarkers, most notably PCT, has high potential to improve the antibiotic management of elderly patients with possible infection for improving both, undertreatment and overtreatment. Within this narrative review, we aim to provide evidence-based concepts for the safe and efficient use of PCT in elderly patients.

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