The Water-Energy-Food-Ecosystems (WEFE) nexus presents a complex web of interactions, capturing the attention of both academia and policymakers. Sectoral policies wield significant impacts across WEFE domains, necessitating a nuanced approach to sustainability initiatives. For a decade, research and policy discussions across Europe have sought to comprehend these interconnections and develop strategies that minimize unintended consequences while maximizing co-benefits. The NEXUSNET Regional Forum convened in Split, Croatia on September 28, 2023, spotlighting stakeholders-practitioners who shape and are shaped by the WEFE nexus. With a focus on Southern Europe, the forum delved into challenges and opportunities, fostering the exchange of experiences and mutual learning among practitioners and policymakers. Diverse organizations were represented by esteemed panelists contributing to a comprehensive exploration of the WEFE nexus. The forum unfolded across three sessions: “Sectoral perspective viewpoint”, “Implementation of nexus cases”, and “Bridging the gap between nexus research and policy”. This paper distills the outcomes, providing a synthesis that transcends individual sessions. It offers a cohesive overview of the forum’s rich discussions, emphasizing the collaborative efforts required to navigate the intricacies of the WEFE nexus and elevate its societal and policy impact.