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Background Implementation involves complex interventions, hence the updated Medical Research Council (MRC) framework for developing and evaluating complex interventions (2021) is one approach implementation scientists could use to guide their research. However, despite extensive citations, there is limited evidence of how it has been used in its entirety and little integration with relevant implementation conceptual knowledge. To address this, we provide a novel example of using the updated MRC framework, uniquely demonstrating the potential for incorporating implementation science frameworks, strategies and outcomes. This example uses a telerehabilitation intervention, NeuroRehabilitation OnLine (NROL), implemented within an existing healthcare system. Methods Within a clinical-academic partnership we completed the MRC Framework checklist, and context was described using the updated Consolidated Framework for Implementation Research (CFIR). We used a deliberative process to operationalise the MRC phases: adaptation of NROL based on the ADAPT guidance and establishing feasibility of NROL through concurrent implementation and evaluation. Phases are described in two iterations: within a single service, then when scaled-up as a regional innovation. Stakeholders were involved throughout. Implementation strategies were identified using the CFIR-ERIC matching tool. Selected Proctor’s implementation outcomes were evaluated. Results The MRC framework provided a useful structure when applied iteratively to address key uncertainties for the implementation, and considerations for sustainability, of the complex intervention NROL. Context description was crucial for phase-specific considerations across iterations. An additional sustainment phase was added to the framework, reflecting that the value proposition discussions with decision-makers inevitably culminated in decision-points. This guided decision-making for NROL to be scaled-up. Implementation Research Logic Models were co-produced and iterated to depict programme theory and formalise integration of implementation conceptual knowledge. Conclusion We provide a novel example of the application of the updated MRC framework being described in full, and to our knowledge is the first to comprehensively integrate implementation conceptual knowledge. Synergistic in nature, the MRC framework benefitted the conceptualisation of implementation through use of its phases, and implementation science knowledge was useful in enacting the core elements within the MRC framework. In this example, we emphasised sustainability throughout and include a distinct ‘Sustainment’ phase to advance the MRC framework.
Background Implementation involves complex interventions, hence the updated Medical Research Council (MRC) framework for developing and evaluating complex interventions (2021) is one approach implementation scientists could use to guide their research. However, despite extensive citations, there is limited evidence of how it has been used in its entirety and little integration with relevant implementation conceptual knowledge. To address this, we provide a novel example of using the updated MRC framework, uniquely demonstrating the potential for incorporating implementation science frameworks, strategies and outcomes. This example uses a telerehabilitation intervention, NeuroRehabilitation OnLine (NROL), implemented within an existing healthcare system. Methods Within a clinical-academic partnership we completed the MRC Framework checklist, and context was described using the updated Consolidated Framework for Implementation Research (CFIR). We used a deliberative process to operationalise the MRC phases: adaptation of NROL based on the ADAPT guidance and establishing feasibility of NROL through concurrent implementation and evaluation. Phases are described in two iterations: within a single service, then when scaled-up as a regional innovation. Stakeholders were involved throughout. Implementation strategies were identified using the CFIR-ERIC matching tool. Selected Proctor’s implementation outcomes were evaluated. Results The MRC framework provided a useful structure when applied iteratively to address key uncertainties for the implementation, and considerations for sustainability, of the complex intervention NROL. Context description was crucial for phase-specific considerations across iterations. An additional sustainment phase was added to the framework, reflecting that the value proposition discussions with decision-makers inevitably culminated in decision-points. This guided decision-making for NROL to be scaled-up. Implementation Research Logic Models were co-produced and iterated to depict programme theory and formalise integration of implementation conceptual knowledge. Conclusion We provide a novel example of the application of the updated MRC framework being described in full, and to our knowledge is the first to comprehensively integrate implementation conceptual knowledge. Synergistic in nature, the MRC framework benefitted the conceptualisation of implementation through use of its phases, and implementation science knowledge was useful in enacting the core elements within the MRC framework. In this example, we emphasised sustainability throughout and include a distinct ‘Sustainment’ phase to advance the MRC framework.
BACKGROUND Extensive literature highlights the effectiveness of parenting programs for early childhood and parental outcomes globally. Increasing evidence shows that digital parenting programs are equally effective as those delivered in-person, and that digital delivery is acceptable to parents. Parenting programs, however, cannot be ‘one-size-fits-all’ but rather need to be developed, adapted, and refined to account for the context, culture, attitudes, behaviours, and expectations of the intended target audience. OBJECTIVE This study aimed to identify the key research lessons learned from Minderoo Foundation’s Thrive by Five International Program, a large-scale digital and non-digital childrearing program. The Medical Research Council’s (MRC) Framework for Developing and Evaluating Complex Interventions emphasises ‘core elements’ that underpin all aspects of the research and development (R&D) process. The MRC Framework guided the approach to synthesising the data from this three-year (2021-2024) Program. The objectives were to: 1) identify critical learnings about the Program; 2) explore how these learnings related to R&D processes and outcomes; and, 3) examine how these may have varied based on sociocultural context. METHODS A multi-case study design was used to build a deep understanding of the Program, including how it varied across, and was influenced by, diverse sociocultural and contextual factors across 10 low- and middle-income countries. The data included field notes and transcriptions from semi-structured and conversational interviews, and group-based workshops. Data analysis occurred over three phases. First, for each case, qualitative data was analysed using established thematic techniques, with all primary findings being summarised into outcome reports. Next, an overarching report was produced for each case to integrate the learnings across all research activities to inform the transfer of learnings to the Program. Finally, a secondary analysis was conducted relating to program theory, stakeholder engagement, and the refinement of the Program as they related to, interacted with, and were influenced by context. RESULTS The analysis resulted in five themes: 1) The role and value of partnerships; 2) Building collaborative practice with partners; 3) Honing a target audience; 4) Navigating the digital landscape; and, 5) Managing linguistic diversity and translation. Learnings regarding context and cultural diversity were integrated throughout the results. CONCLUSIONS Digital health interventions must be appropriate for and accessible to the target audience, aligned with ICT infrastructure and policies, and fill a need in the digital health marketplace. When this is not feasible, a multi-channel approach to dissemination using digital and non-digital strategies is necessary. While likely to increase project complexity, cross-sectorial partnerships, including with government bodies, are likely to broaden Program reach. To facilitate digital health projects, it is critical that sufficient time be allocated to build meaningful collaborative partnerships centred on respect, cultural understanding, and open communication and grounded by a shared vision.
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