Introduction

Jin, Lee Kiat; Yun, Hing Ai

doi:10.1163/156848409x12474536440465

Cited by 1 publication

(3 citation statements)

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“…20 It was reported that a burst release of BSA was found in the case of a chitosan-alginate blend as a delivery system. 26 Jin et al 27 reported that 50% of the encapsulated BSA was released within 30 min, and it was more than 60% by 1 h at pH 1.2. The cumulative release of BSA in PBS (pH 7.4) was more than 80% at 2 h. As reported by Mladenovska et al, 39 an initial rapid release followed by a continuous slower release of BSA was observed in case of the gelatin microspheres.…”

Section: Bsa Release From the Calcium-pu-alginate Beadsmentioning

confidence: 99%

“…All of the dissolution runs were performed in triplicate. The cumulative amount of drug released at different time intervals were calculated from the following formula 27 and plotted against time to study the BSA release pattern:…”

Section: Swelling Study Of the Pu-alginate Beads In Different Phmentioning

confidence: 99%

“…The physicochemical properties and the swelling degree of polymers synthesized from PEG depended on the molecular weight of PEG. 27 This could be explained from the fact that the hydrophilic content of the PU helped in the greater binding of water molecules to the polymer network, and the degree of swelling increased accordingly. The swelling study of the PU films were also executed in different pH media, but these results did not establish a valid difference to support pH sensitivity.…”

Section: Nmr Analysismentioning

confidence: 99%

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Synthesis of a novel pH‐sensitive polyurethane–alginate blend with poly(ethylene terephthalate) waste for the oral delivery of protein

Bhattacharyya

Mukhopadhyay

Kundu

2014

J of Applied Polymer Sci

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With the aim of using poly(ethylene terephthalate) (PET) waste for the synthesis of a value added product, we prepared polyurethane (PU) from bishydrohxyethylene terephthalate (BHET), a byproduct obtained from the glycolysis of PET. Biodegradable, waterswelling PU was synthesized by the reaction of BHET, hexamethylene diisocyanate, and poly(ethylene glycol) (PEG). Both BHET and PU were characterized by Fourier transform infrared spectroscopy, and the formation of PU was further confirmed by NMR analysis. The swelling behavior of PU in water was examined in terms of the various molecular weights of PEG. Semi-interpenetrating network beads of PU and sodium alginate were prepared with calcium chloride (CaCl 2 ) as a crosslinker to attain a pH sensitivity for successful oral protein/drug delivery. Bovine serum albumin (BSA) was used as a model protein. The pH-responsive swelling behavior and protein (BSA) release kinetics in different pH media corresponding to the gastrointestinal tract (pH 1.2 and 7.4) were investigated. The degree of swelling in the case of the PU-alginate beads at pH 1.2 was found to be at a minimum, whereas the degree of swelling was significantly elevated (1080%) at pH 7.4. This substantiated the pH sensitivity of the polymeric beads with a minimum loss of encapsulated protein in the stomach and the almost complete release of encapsulated protein in the intestine. This revealed good opportunities for oral protein/ drug delivery with a polymer derived from waste PET. Moreover, the fungal biodegradation study confirmed its compatibility with the ecological system.

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Section: Bsa Release From the Calcium-pu-alginate Beadsmentioning

confidence: 99%

Section: Swelling Study Of the Pu-alginate Beads In Different Phmentioning

confidence: 99%

Section: Nmr Analysismentioning

confidence: 99%

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