Introduction: Biocatalysis in Industry

Hughes, Greg; Lewis, Jared C.

doi:10.1021/acs.chemrev.7b00741

Cited by 117 publications

(70 citation statements)

References 17 publications

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“…In fact, a change has been made in the objectives required for a chemical reaction, from the traditional concepts of efficiency and selectivity that focused mainly on chemical yield, to others where priorities are the maximal utilization of raw materials, low pollutant production, and eliminating the use of toxic and/or hazardous substances . Accordingly, biocatalysis, defined as the use of enzymes or whole cells as catalysts for industrial synthetic chemistry, offers multiple advantages over conventional chemical catalysis . Whole cells and enzymes are nature‘s sustainable, renewable and biodegradable catalysts, which are used under mild temperature, pressure and pH conditions.…”

Section: Introductionmentioning

confidence: 99%

“…[1] Accordingly, biocatalysis, defined as the use of enzymes or whole cells as catalysts for industrial synthetic chemistry, [2] offers multiple advantages over conventional chemical catalysis. [3] Whole cells and enzymes are nature's sustainable, renewable and biodegradable catalysts, which are used under mild temperature, pressure and pH conditions. Water is employed as an environmentally friendly solvent, [4] and no heavy metals are used.…”

Section: Introductionmentioning

confidence: 99%

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Improved Biocatalytic Activity of the Debaryomyces Species in Seawater

Andreu

Olmo

2019

ChemCatChem

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Biocatalysis is an environmentally friendly strategy widely used in the chemical and pharmaceutical industries. One of its approaches consists in utilizing whole cells, which usually involves the consumption of large quantities of water. Oceans cover a large part of the Earth's surface, and constitute an important reservoir that can be used as an alternative to freshwater in chemical reactors. This work analyzed the behavior of several yeast halotolerant species belonging to genera Debaryomyces and Schwanniomyces in both freshwater and seawater. It concluded that these microorganisms were more resistant to organic solvents/compounds in the second medium. Their metabolic activity was also greater, which made the reduction reaction of several prochiral ketones more effective. Besides, yeasts cells displayed better performance in subsequent recycling steps, which could help reduce the costs of the process.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Improved Biocatalytic Activity of the Debaryomyces Species in Seawater

Andreu

Olmo

2019

ChemCatChem

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“…Numerous commercially applied methods cover resolution processes using racemates as well as asymmetric biocatalytic conversions starting from pro‐chiral compounds. The basic principle of resolution‐type reactions is the enzymatic resolution of racemates and asymmetric (bio)catalysis . More recently, protein systems have been described for chemical reactions such as enantioselective cyclopropanations, silylations and borylations .…”

Section: The Stereochemistry Approach In Agrochemistrymentioning

confidence: 99%

Current status of chirality in agrochemicals

Jeschke

2018

Pest Management Science

152

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The agrochemical industry is searching continuously for new pesticides to develop products that have optimal efficacy, lower application rates in the field, increased selectivity, favourable toxicological and environmental safety, enhanced user friendliness and better economic viability. One strategy by which to achieve these ambitious goals makes use of the unique properties of molecules containing asymmetric centres. In the past, many natural products and their congeners have been a source of inspiration in the design of new active ingredients, and the molecular structures of the resulting compounds have become increasingly complex; some 30% contain fragments with asymmetric centres. However, despite enormous progress in catalytic asymmetric processes over the past decade, few agrochemicals are produced in an enantiomerically pure or enriched form on an industrial scale. Since 2007, ∼ 43% of the 44 products launched (insecticides, acaricides, fungicides, nematicides and herbicides) contain one or more asymmetric centres in the molecule (∼ 47%) and most have been launched as racemic mixtures of enantiomers or diastereomers. This review provides an overview of the current status of chiral agrochemicals launched over the past 10 years and describes the inherently connected challenges of modern agricultural chemistry by managing important aspects resulting from the stereochemistry of these innovative products. © 2018 Society of Chemical Industry.

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“…Enzyme mediated biocatalysis offers a more cost-effective and environmentally sustainable way of generating biotechnologically valuable chemicals when compared with traditional chemical syntheses (Hughes and Lewis 2018). H. volcanii possesses alcohol dehydrogenase (ADH) enzymes, which catalyse the production of important building blocks in fine chemical, flavour and fragrance industries such as chiral alcohols (Chapuis and Jacoby 2001;Schmid et al 2001).…”

Section: Biotechnological Potential Of H Volcaniimentioning

confidence: 99%

Haloferax volcanii for biotechnology applications: challenges, current state and perspectives

Haque

Paradisi

Allers

2019

Appl Microbiol Biotechnol

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Haloferax volcanii is an obligate halophilic archaeon with its origin in the Dead Sea. Simple laboratory culture conditions and a wide range of genetic tools have made it a model organism for studying haloarchaeal cell biology. Halophilic enzymes of potential interest to biotechnology have opened up the application of this organism in biocatalysis, bioremediation, nanobiotechnology, bioplastics and the biofuel industry. Functionally active halophilic proteins can be easily expressed in a halophilic environment, and an extensive genetic toolkit with options for regulated protein overexpression has allowed the purification of biotechnologically important enzymes from different halophiles in H. volcanii. However, corrosion mediated damage caused to stainless-steel bioreactors by high salt concentrations and a tendency to form biofilms when cultured in high volume are some of the challenges of applying H. volcanii in biotechnology. The ability to employ expressed active proteins in immobilized cells within a porous biocompatible matrix offers new avenues for exploiting H. volcanii in biotechnology. This review critically evaluates the various application potentials, challenges and toolkits available for using this extreme halophilic organism in biotechnology.

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Introduction: Biocatalysis in Industry

Cited by 117 publications

References 17 publications

Improved Biocatalytic Activity of the Debaryomyces Species in Seawater

Improved Biocatalytic Activity of the Debaryomyces Species in Seawater

Current status of chirality in agrochemicals

Haloferax volcanii for biotechnology applications: challenges, current state and perspectives

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