Introduction of a multicenter online database for non-metastatic breast cancer in China

Yang, Yaping; Liu, Jieqiong; Peng, Min; Su, Fengxi; Xie, Xiaoming; Liu, Zhenzhen; Wu, Jundong; Wei, Wei; Zhou, Dongxian; Li, Weiwen; Zhang, Ailing; Su, Guohai; Yang, Weixiong; Chen, Jishang; Ma, Ding; Cai, Yong; Chen, Kai; Zhu, Liling; Liu, Qiang; Song, Erwei

doi:10.1007/s11427-019-1625-1

Cited by 9 publications

(5 citation statements)

References 5 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“… 2 , 3 The median age of breast cancer patients in the United States is 62–64 years, while in East Asian countries such as China, the median age is about 45–49 years. 4 , 5 The United States accounted for only 4% of new breast cancer cases under the age of 40 in 2019, 6 while a study in China showed that 16.4% of new breast cancer cases occurred under the age of 40 in 2017. 7 …”

Section: Introductionmentioning

confidence: 99%

Landscape of young breast cancer under 35 years in China over the past decades: a multicentre retrospective cohort study (YBCC-Catts study)

Wang,

Xia,

Wang

et al. 2023

eClinicalMedicine

View full text Add to dashboard Cite

Section: Introductionmentioning

confidence: 99%

Landscape of young breast cancer under 35 years in China over the past decades: a multicentre retrospective cohort study (YBCC-Catts study)

Wang,

Xia,

Wang

et al. 2023

eClinicalMedicine

View full text Add to dashboard Cite

“…Efforts such as providing social support, establishing good patient–physician relationship, and minimizing the side effects of therapy should be made to address this problem for these very young HR+/HER2− breast cancer patients. This study was based on the multicenter online database “Yixian Database” ( 5 ), and 11,671 women with breast cancer were included, which was a large cohort to explore the very young breast cancer patients’ characteristics and prognosis. Because of the higher-grade tumors and more triple-negative subtype for these very young patients, they also had the worst survival outcomes than the other age groups.…”

Section: Discussionmentioning

confidence: 99%

“…Approximately 10.3% (1,207/11,671) female breast cancer patients were ≤35 years old during this period of time. The demographic and clinicopathological data and treatment variables were collected from a multicenter online database, “Yixian Database” ( 16 ), with strict privacy standards. Survival data were obtained from the follow-up registry of each center and follow-up data were censored on January 31, 2021.…”

Section: Methodsmentioning

confidence: 99%

“…A report from the Chinese Cancer Center showed that China had 3.8 million new patients with malignant tumor in 2014, including new 1.69 million female malignant tumor patients, in which the number of newly diagnosed breast cancer accounted for 16.51% (4). The median age at diagnosis of Chinese female patients with breast cancer is 48 years old, which is 14 years younger than that of breast cancer women (62 years old) reported by the Surveillance Epidemiology and End Results (SEER) database (5).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Comparison of the Characteristics and Prognosis Between Very Young Women and Older Women With Breast Cancer: A Multi-Institutional Report From China

Yang

Wei-dong

et al. 2022

Front. Oncol.

Self Cite

View full text Add to dashboard Cite

PurposeOur understanding of breast cancer in very young women (≤35 years old) remains limited. We aimed to assess the clinicopathological characteristics, molecular subtype, and treatment distribution and prognosis of these young patients compared with patients over 35 years.MethodsWe retrospectively analyzed non-metastatic female breast cancer cases treated at three Chinese academic hospitals between January 1, 2008, and December 31, 2018. Local recurrence-free survival (LRFS), disease-free survival (DFS), and overall survival (OS) were compared between different age groups and stratified with distinct molecular subtypes.ResultsA total of 11,671 women were eligible for the final analyses, and 1,207 women (10.3%) were ≤35 years at disease onset. Very young breast cancer women were more likely to be single or childless, have higher-grade disease, have more probability of lymphovascular invasion (LVI) in tumor and triple-negative subtype, and be treated by lumpectomy, chemotherapy especially more anthracycline- and paclitaxel-based chemotherapy, endocrine therapy plus ovarian function suppression (OFS), anti-HER2 therapy, and/or radiotherapy than older women (P < 0.05 for all). Very young women had the lowest 5-year LRFS and DFS among all age groups (P < 0.001 for all). When stratified by molecular subtype, very young women had the worst outcomes vs. women from the 35~50-year-old group or those from >50-year-old group for hormone receptor-positive (HR+)/human epidermal growth factor receptor 2-negative (HER2−) subtype, including LRFS, DFS, and OS (P < 0.05 for all). In terms of LRFS and DFS, multivariate analyses showed similar results among the different age groups.ConclusionOur study demonstrated that very young women with breast cancer had higher-grade tumors, more probability of LVI in tumor, and more triple-negative subtype, when compared with older patients. They had less favorable survival outcomes, especially for patients with the HR+/HER2− subtype.

show abstract

“…Studies have also confirmed that the age at onset of breast cancer in East Asian countries, including China, is younger compared to Western countries, with a median age of onset of 45 to 49 years. [ 1 ] The loss of breast shape after breast cancer surgery has a negative impact on the psychological, physiological, and quality of life of female patients. [ 2 ] Additionally, with the improvement in early screening and treatment of breast cancer, the survival rate of patients has significantly increased.…”

Section: Introductionmentioning

confidence: 99%

Triplane technique for breast reconstruction after breast cancer surgery: A case series report

Yang,

Wang,

Zou

et al. 2024

Medicine

View full text Add to dashboard Cite

Rationale: Implant-based breast reconstruction is an important method for post-mastectomy breast reconstruction. Currently, the most commonly used technique is the biplane technique. However, the high rate of postoperative complications, the inability of pockets to accommodate larger implants, and the expensive costs of biological mesh make the development of new surgical methods urgent. The triplane technique for breast reconstruction is an ideal candidate method. Patient concerns: The main local symptoms were breast lump, abnormal breast skin, nipple discharge, and abnormal nipple or areola in 24 patients. Diagnoses: The study included 24 female patients who underwent breast reconstruction using the triplane technique after radical breast cancer surgery. Interventions: The surgical procedure involved measuring the dimensions of the breast, designing the incision, and creating a pocket for the implant using the triplane technique, which includes the pectoralis major muscle, the pectoralis major fascia continuing to the rectus abdominis fascia, and the latissimus dorsa muscle fascia continuing to the rectus abdominis fascia. Postoperative follow-up included regular assessments of pain and evaluation of breast appearance. Outcomes: No cases of postoperative infection were observed in all patients. During the 1-year follow-up period after surgery, 5 patients (20.8%) who needed radiotherapy after mastectomy for cancer showed slight darkening of skin flap pigment after using the triplane technique implant. No cases of exposure or infection of the expanders were reported, and 1 patient underwent expander replacement with a permanent prosthesis. All patients expressed satisfaction with the reconstructed breast shape. The 10 patients (41.7%) experiencing postoperative swelling and pain. However, the pain gradually subsided during the postoperative recovery period. No cases of local recurrence or distant metastasis of breast cancer were observed during the 1-year-follow-up period. Lessons: The triplane technique for breast reconstruction after breast cancer surgery provides good implant coverage, reduces the risk of complications, and is cost-effective.

show abstract

Introduction of a multicenter online database for non-metastatic breast cancer in China

Cited by 9 publications

References 5 publications

Landscape of young breast cancer under 35 years in China over the past decades: a multicentre retrospective cohort study (YBCC-Catts study)

Landscape of young breast cancer under 35 years in China over the past decades: a multicentre retrospective cohort study (YBCC-Catts study)

Comparison of the Characteristics and Prognosis Between Very Young Women and Older Women With Breast Cancer: A Multi-Institutional Report From China

Triplane technique for breast reconstruction after breast cancer surgery: A case series report

Contact Info

Product

Resources

About