Introduction of an examination and treatment for Helicobacter pylori infection in high school health screening

Akamatsu, Taiji; Ichikawa, Shinya; Okudaira, Sadahide; Yokosawa, Shuichi; Iwaya, Yugo; Suga, Tomoaki; Ota, Hiroyoshi; Tanaka, Eiji

doi:10.1007/s00535-011-0450-6

Cited by 41 publications

(42 citation statements)

References 19 publications

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“…There are already several reports on the prevalence of H. pylori infection in Japanese children ranging from 1.8% in Hyogo to 12% in Aomori (Supplement 1) [15][16][17][18]. The prevalence was generally lower in children than in adults [19,20], reflecting the decreasing trend of infection over the past decades.…”

Section: Discussionmentioning

confidence: 98%

The administrative project of Helicobacter pylori infection screening among junior high school students in an area of Japan with a high incidence of gastric cancer

et al. 2017

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Objective Helicobacter pylori infection is a common chronic infection that is closely associated with gastric cancer, known to be decreasing worldwide. We set up an administrative project of screening examination for H. pylori infection in junior high school students in Akita Prefecture to investigate the current prevalence of H. pylori infection in childhood in an area where the incidence of gastric cancer is particularly high. Subjects and methods All students in their second or third year of junior high school (13 to 15 years old) in two cities in Akita Prefecture were recruited. First, a urine-based enzyme-linked immunosorbent assay for detection of H. pylori antibody was performed. Then, a 13 C-urea breath test ( 13 C-UBT) was carried out in students who tested positive on the urinary test. Written informed consent was obtained from all participants and their parents. Results A total of 1813 students were recruited in this study; 1765 (97.3%) students agreed to participate in this project and underwent a screening examination. Among 96 students (5.4%) testing positive for H. pylori on the initial screening examination, 90 (93.7%, 90/96) underwent a subsequent 13 C-UBT, and 85 (4.8%, 85/1765) were diagnosed as positive for H. pylori. Conclusions The current prevalence of H. pylori infection among students was low even in an area of Japan with a high incidence of gastric cancer.

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Section: Discussionmentioning

confidence: 98%

The administrative project of Helicobacter pylori infection screening among junior high school students in an area of Japan with a high incidence of gastric cancer

et al. 2017

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“…In Japan, the prevalence of H. pylori is low in students and young adults who are not entitled to receive gastric cancer screening. Recently, there has been a significant increase in the number of local governments introducing test-to-treat strategies to eliminate H. pylori infection in students or young adults in Japan (2,3). This strategy is most important in regions with a high prevalence of H. pylori infection and high incidence of gastric cancer, such as the Japan Sea region of northern Japan.…”

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confidence: 99%

Accuracy of a Stick-Type Kit and Enzyme-Linked Immunosorbent Assay in Detecting <i>Helicobacter pylori</i> Antibodies in Urine of People Living in the Japan Sea Region of Northern Japan

Shimoyama

Sawada²,

Sawada

et al. 2017

Jpn J Infect Dis

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SUMMARY:In Japan, both a stick-type kit and an enzyme-linked immunosorbent assay (ELISA) kit are available for the detection of antibodies to Helicobacter pylori in urine. However, the accuracy of these tests has not been fully examined in northern Japanese populations. Urine samples from 359 subjects were tested using a stick-type H. pylori-antibody detection kit (RAPIRUN), and urine samples from 201 subjects were tested using an ELISA-based test (URINELISA). The prevalence of H. pylori infection was determined by the 13 C-urea breath test (UBT) and a monoclonal antibody-based stool antigen test (TPAg). Subjects were considered to have the infection if either the UBT or rapid TPAg results were positive. The percentage of positive test results for RAPIRUN and URINELISA was 54.0z and 40.8z, respectively. Sensitivity and specificity were 83.3z and 67.0z, respectively, for RAPIRUN and 86.5z and 85.8z for URINELISA. Nineteen subjects had cut-off index values of between 0.4 and 0.9 by URINELISA, and 4 of these subjects (21.1z) were found to be infected with H. pylori. The urine-based ELISA was more accurate than the rapid stick-type kit in these patients. If negative ELISA results are near the cut-off value, subjects should receive an additional test to determine whether they are infected with H. pylori.

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“…Furthermore, the curing of H. pylori infection would also prevent other H. pylori related diseases such as gastroduodenal ulcer, gastric MALT lymphoma, and idiopathic thrombocytopenic purpura etc. Therefore, the screening and treatment for H. pylori infection in young people is thought to be useful from the view point of medical economy [5]. If further examination for H. pylori infection were to be performed not by using endoscopy but using UBT or the stool antigen of H. pylori, the total cost of this attempt would be more reduced [6], especially the cost of further examination of H. pylori infection would become about one fifth.…”

Section: Discussionmentioning

confidence: 99%

“…We have proposed that a screening for H. pylori infection should be introduced into health screenings in school, and have performed this procedure in one Japanese high school every year since 2007 [5,6]. All students of the second year in high school were annually examined about the status of H. pylori infection using urine-based rapid test kit (RUPIRUN ® , Otsuka Pharmaceutical Co. Tokyo, Japan) [7].…”

Section: Screening and Treatment For H Pylori Infection In High Schomentioning

confidence: 99%

Screening and Treatment for Helicobacter pylori Infection in Teenagers in Japan

Akamatsu¹,

Uehara²

2016

J Gastrointest Dig Syst

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To elucidate the prevalence and effect of H. pylori infection in Japanese teenagers, we underwent an examination and treatment of it in one high school health screening between 2007 and 2015. The study subjects were students ages 16 to 17. Students who tested positive on this screening using urine-based rapid test kits (RUPIRAN ® ) examination visited Shinshu University Hospital and underwent esophagogastroduodenoscopy (EGD) and were taken biopsy samples to determine their H. pylori status using culture and histology. Cure of H. pylori infections was determined by urea breath test. For 9 years, 4,297 of 4,312 students (99.7%) received a screening examination for H. pylori infection. One hundred and sixty-two of 4,297 students (3.8%) were positive for H. pylori. Ninety-three of these 162 with H. pylori-positive students visited our hospital, and 91 underwent EGD and 78 (85.7%) were confirmed to be H. pylori infected. The most common endoscopic findings for H. pylori infection were nodular gastritis (80.8%) and closed-type atrophic gastritis (61.5%). A scar from duodenal ulcer was recognized in 6 of them (7.7%), and intestinal metaplasia was histologically present in two. All 78 students with H. pylori infection and their parents agreed to receive eradication therapy using regimens according to the susceptibility of H. pylori. Finally, all except 3 were successfully cured of H. pylori infection. Remaining 3 students have not yet been assessed the decision of H. pylori infection. If this procedure were to be introduced into nationwide health screening at Japanese high schools, we calculated that the cost of the prevention of a gastric cancer would be 495,958 yen (4,508.71dollars) for each person. The low rate of prevalence of H. pylori infection in present Japanese teenagers would make it possible to perform the screening examination and treatment for this infection in nationwide health screening of high school students in the way that is practical and feasible.

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Introduction of an examination and treatment for Helicobacter pylori infection in high school health screening

Abstract: The low rate of prevalence of H. pylori infection in Japanese teenagers would make it possible to perform examinations and carry out treatment for this infection in high school health screenings from the standpoint of medical economy.

Cited by 41 publications

References 19 publications

The administrative project of Helicobacter pylori infection screening among junior high school students in an area of Japan with a high incidence of gastric cancer

The administrative project of Helicobacter pylori infection screening among junior high school students in an area of Japan with a high incidence of gastric cancer

Accuracy of a Stick-Type Kit and Enzyme-Linked Immunosorbent Assay in Detecting <i>Helicobacter pylori</i> Antibodies in Urine of People Living in the Japan Sea Region of Northern Japan

Screening and Treatment for Helicobacter pylori Infection in Teenagers in Japan

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