Introduction of Difluoromethyl Through Radical Pathways

Abstract

During the past decade, radical difluoromethylation has received much attention and rapid developments for its mild reaction conditions and good functional group compatibilities. A diverse array of difluoromethyl radical precursors and corresponding radical reactions have been disclosed. This review summarizes and discusses the recent progress on the radical difluoromethylation reactions, which are organized according to the protocols of generating difluoromethyl radical.