Introduction of Electrochemical Therapy (EChT) and Application of EChT to The Breast Tumor

Abstract

Results: In animal study, There were destructive change including vaculated cell fragment and extensive coagulative necrosis. Case 1 showed no local recurrence during 18 monthes after EChT. Case 2 also showed no evidence of recurrence of hemangioma. Conclusion:The EChT is easy to use. It is effective, safe, less traumatic and makes patients recover quickly. This is a new and effective method to treat patients with tumours that are inoperable and can not receive chemotherapy or radiotherapy. (J Breast Cancer 2007;10:162-8)

Electrotherapy on Cancer: Experiment and Mathematical Modeling

“…sources and radial arrays of electrodes with finite length. The results of the simulations reveal as these distributions in the tumor and its surrounding healthy tissue change in function of the tumor size, the positioning, number and polarity of the electrodes, and the difference of electrical conductivity between both tissues for, in agreement with previous theoretical studies [Aguilera et al, 2009;Aguilera et al 2010;Čorović et al, 2007;Jiménez et al, 2011;Joa, 2010;Reberšek et al, 2008;Šel et al, 2003] and experimental reports [Chou et al, 1997;Ren et al, 2001;Serša et al, 1997;Turler et al, 2000;Xin et al, 1994;Yoon et al, 2007]. 3D-analytical expressions for the potential, electric field intensity and electric current density generated by wires completely inserted in the tumor along their diameters (plane y = 0 cm) are directly obtained from the application of this mathematical theorem and the parametric form of the curve given in equation (3).…”

“…The destroyed cancerous tissue is eliminated from the body and is replaced by scar tissue and then in the majority of the patients, we observe tissue granulation when the tumor is removed after this treatment [Jarque et al, 2007]. Similar results are reported in laboratory animal [Cabrales et al, 2001;Ciria et al, 2004;Haltiwanger, 2008;Mikhailovskaya et al, 2009;Sazgarnia et al, 2009;Vijh, 2006] and human [Arsov et al, 2009;Haltiwanger, 2008;Jarque et al, 2007;Li et al, 2006;Salzberg et al, 2008;Vijh, 2006;Vogl et al, 2007;Xin et al, 2004;Yoon et al, 2007]. The use of this electrodes array stops the bloody flux of this patient for the vulva immediately after the electrotherapy application due to the haemostatic effect of the cathode.…”

“…This figure shows the Ehrlich tumor growth kinetics for the control group (CG) and different treated groups: TG1 (treated group with electrical charge of 6.7 mA for 45 min), TG2 (treated group with 11.7 mA for 45 min), and TG3 (treated group with 17 mA for 45 min). The minimum of the amount of volumetric electric charge required for the tumor destruction must be 35 coulombs/cm 3 ; however, high antitumor effectiveness is obtained when this physical magnitude is between 80 and 100 coulombs/cm 3 [Jarque et al, 2007;Ren et al, 2001;Xin et al, 2004;Yoon et al, 2007], in agreement with 92 and 80 coulombs/cm 3 for which the Ehrlich (TG3 in Figure 1) and fibrosarcoma Sa-37 tumors are completely destroyed, respectively [Ciria et al, 2004]. Fig.…”

“…Direct current brings about long lasting pain relief because it inhibits the activity of sensory nerve fibers. In the literature are reported different adverse events (effects), as: fever, wound infections, damages to the blood vessels when the electrodes are inserted close of these [Arsov et al, 2009;Haltiwanger, 2008;Jarque et al, 2007;Li et al, 2006;Salzberg et al, 2008;Vijh, 2006;Vogl et al, 2007;Xin et al, 2004;Yoon et al, 2007]. The underlying mechanisms more widely accepted are the toxic products from of the electrochemical reactions and change of pH.…”

“…Many different forms of electrical current with respect to frequencies, pulse-shapes and amplitudes have been employed in biomedicine with the aim of remodeling tissues by enhancing or suppressing cell proliferation. One of the scopes is also employment of direct current as an antitumor agent [Cabrales et al, 2001;Ciria et al, 2004;Jarque et al, 2007;Ren et al, 2001;Schaefer et al, 2008;Turler, et al, 2000;Vodovnik et al, 1992;Xin et al, 2004;Yoon et al, 2007].…”