Introduction of Nature's Complexity in Engineered Blood‐compatible Biomaterials

Ippel, Bastiaan D.; Dankers, Pyw Patricia

doi:10.1002/adhm.201700505

Cited by 38 publications

(20 citation statements)

References 167 publications

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“…For biomedical applications, control over the adhesion of cells and adsorption of proteins at the biomaterial surface is important to tune the response to tissue the biomaterial is exposed to . Antifouling functionalization is often used to improve biomaterial performance to resist fouling, or to aid in specific bioactivation . Besides covalent strategies functional antifouling additives can be simply mixed with base polymers to create biomaterials with antifouling properties.…”

Section: Introductionmentioning

confidence: 99%

Supramolecular Antifouling Additives for Robust and Efficient Functionalization of Elastomeric Materials: Molecular Design Matters

Ippel

Keizer

Dankers

2018

Adv Funct Materials

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The ultimate functionality of elastomeric materials can be largely influenced by the molecular design of antifouling additives that interact through directed hydrogen bonding bisurea motifs. Herein, three additives, composed of matching bisurea groups and antifouling oligo(ethylene glycol) (OEG) functionalities, are judiciously designed. The first additive is composed of one bisurea and one OEG, the second additive of one bisurea and two OEGs, and the third additive of two bisurea and one OEG. On solution-cast films, non-cell adhesive properties are dependent on the amount of incorporated OEG irrespective of the bisurea design; however, on 3D electrospun scaffolds only the additive that consists of two bisurea moieties connected via an OEG functionality ensures proper non-cell adhesive properties. Interestingly, robust non-cell adhesive properties are maintained, both with repeated cell seeding and after partial enzymatic degradation of the scaffold. These results highlight the importance of additive design in supramolecular functionalization and show that translation from simple 2D solution-cast films to 3D electrospun scaffolds is not trivial with respect to additive presentation and functionality.

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Section: Introductionmentioning

confidence: 99%

Supramolecular Antifouling Additives for Robust and Efficient Functionalization of Elastomeric Materials: Molecular Design Matters

Ippel

Keizer

Dankers

2018

Adv Funct Materials

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“…Here, we focus on the recent progresses made in the development of fibrinolytic surfaces by Chen et al; further, the first two strategies are not described in detail due to space limitations; interested readers should refer to other excellent reviews. 431,453,454 Generally, fibrinolytic surfaces mimic the naturally occurring fibrinolytic processes in the body by the generation of a clot-lysing enzyme called plasmin to break down the nascent clot before it poses any danger. 455 The two main proteins involved in this process were plasminogen (Plg)-a precursor of plasmin-and a plasminogen activator (e.g., tissue plasminogen activator, tPA).…”

Section: Interactions Of Biomaterials Surfaces/interfacesmentioning

confidence: 99%

Advanced functional polymer materials

Wang¹,

Amin²,

An³

et al. 2020

Mater. Chem. Front.

146

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“…synthetic biomaterials often allow greater control over physical properties such as mechanical stiffness, degradation rate, and porosity [43,44]. More recently, smart synthetic biomaterials with enhanced functionality such as self-assembly, self-healing, thermo-responsiveness, and pH-responsiveness have also been developed for TE applications [45][46][47][48]. Some examples of synthetic biomaterials that have been extensively used for the engineering of cardiovascular constructs include poly (ethylene glycol) (PEG) [49], poly (ε-caprolactone) (PCL) [50], poly (L-lactic acid) (PLA) [51], poly (glycolic acid) (PGA) [52], and biodegradable polyurethanes (PUs) [53].…”

Section: Biomimetic Design Of Biomaterials For Cardiovascular Tementioning

confidence: 99%

Biomimetic cardiovascular platforms for in vitro disease modeling and therapeutic validation

et al. 2019

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Bioengineered tissues have become increasingly more sophisticated owing to recent advancements in the fields of biomaterials, microfabrication, microfluidics, genetic engineering, and stem cell and developmental biology. In the coming years, the ability to engineer artificial constructs that accurately mimic the compositional, architectural, and functional properties of human tissues, will profoundly impact the therapeutic and diagnostic aspects of the healthcare industry. In this regard, bioengineered cardiac tissues are of particular importance due to the extremely limited ability of the myocardium to self-regenerate, as well as the remarkably high mortality associated with cardiovascular diseases worldwide. As novel microphysiological systems make the transition from bench to bedside, their implementation in high throughput drug screening, personalized diagnostics, disease modeling, and targeted therapy validation will bring forth a paradigm shift in the clinical management of cardiovascular diseases. Here, we will review the current state of the art in experimental in vitro platforms for next generation diagnostics and therapy validation. We will describe recent advancements in the development of smart biomaterials, biofabrication techniques, and stem cell engineering, aimed at recapitulating cardiovascular function at the tissue- and organ levels. In addition, integrative and multidisciplinary approaches to engineer biomimetic cardiovascular constructs with unprecedented human and clinical relevance will be discussed. We will comment on the implementation of these platforms in high throughput drug screening, in vitro disease modeling and therapy validation. Lastly, future perspectives will be provided on how these biomimetic platforms will aid in the transition towards patient centered diagnostics, and the development of personalized targeted therapeutics.

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Introduction of Nature's Complexity in Engineered Blood‐compatible Biomaterials

Cited by 38 publications

References 167 publications

Supramolecular Antifouling Additives for Robust and Efficient Functionalization of Elastomeric Materials: Molecular Design Matters

Supramolecular Antifouling Additives for Robust and Efficient Functionalization of Elastomeric Materials: Molecular Design Matters

Advanced functional polymer materials

Biomimetic cardiovascular platforms for in vitro disease modeling and therapeutic validation

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