Abstract:Phosphonylation of kojic acid has been achieved using inorganic diphosphonate (DP) in aqueous solution. The optimum condition for the phosphonylation of kojic acid with DP is kojic acid : DP = 0.1 mol/L : 0.5 mol/L, pH 9 and 25 ºC. 2-Phosphonylmethyl-kojic acid was synthesized with the yield of 45 %. The reaction mechanism of kojic acid with DP was discussed. We have successfully introduced the phosphonate group in kojic acid. Phosphonylated kojic acid is expected that the permeability of kojic acid into the s… Show more
Set email alert for when this publication receives citations?
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.