Introduction of salvage prostatectomy in Denmark: the initial experience

Mortensen, Mike Allan; Poulsen, Charlotte Aaberg; Ahlgren, Göran; Madsen, Kirsten; Poulsen, Mads Hvid

doi:10.1186/s13104-022-06076-2

Cited by 3 publications

(3 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Twentyone studies defined continence as no pads use (10, 12, 15-22, 25, 26, 30, 31, 33, 35-40), five studies considered up to one pad (8,9,23,28,32), one study evaluated continence using EPIC-26 questionnaire 24, and one study considered the ICIQ-score questionnaire (29). We were not able to find continence definition in five studies (11,13,14,27,34).…”

Section: Functional Outcomesmentioning

confidence: 88%

“…Functional outcomes are illustrated in Tables 1 and 2. The continence rates ranged from 0 to 100% (14,24,33,34), and the studies diverge regarding the definition of continence. Twentyone studies defined continence as no pads use (10, 12, 15-22, 25, 26, 30, 31, 33, 35-40), five studies considered up to one pad (8,9,23,28,32), one study evaluated continence using EPIC-26 questionnaire 24, and one study considered the ICIQ-score questionnaire (29).…”

Section: Functional Outcomesmentioning

confidence: 99%

“…One study evaluated potency recovery using the EPIC-26 questionnaire 24, and two studies using the IIEF-5 ( 29 , 36 ). In some studies, we were not able to find data on potency ( 11 - 13 , 17 , 23 , 27 , 28 , 30 , 32 , 34 , 35 , 38 ), continence, or BCR. Finally, most authors described the number of events in the follow-up period and failed to demonstrate functional outcomes in Kaplan-Meyer curves (time to event) to estimate early potency or continence following surgery.…”

Section: Evidence Synthesismentioning

confidence: 99%

See 2 more Smart Citations

Outcomes of Salvage Robotic-assisted Radical Prostatectomy in the last decade: systematic review and perspectives of referral centers.

Moschovas,

Bravi,

Dell'Oglio

et al. 2023

Int. braz j urol.

View full text Add to dashboard Cite

Purpose: Salvage robotic-assisted radical prostatectomy (S-RARP) has gained prominence in recent years for treating patients with cancer recurrence following non-surgical treatments of Prostate Cancer. We conducted a systematic literature review to evaluate the role and outcomes of S-RARP over the past decade. Material and Methods: A systematic review was conducted, encompassing articles published between January 1st, 2013, and June 1st, 2023, on S-RARP outcomes. Articles were screened according to PRISMA guidelines, resulting in 33 selected studies. Data were extracted, including patient demographics, operative times, complications, functional outcomes, and oncological outcomes. Results: Among 1,630 patients from 33 studies, radiotherapy was the most common primary treatment (42%). Operative times ranged from 110 to 303 minutes, with estimated blood loss between 50 to 745 mL. Intraoperative complications occurred in 0 to 9% of cases, while postoperative complications ranged from 0 to 90% (Clavien 1-5). Continence rates varied (from 0 to 100%), and potency rates ranged from 0 to 66.7%. Positive surgical margins were reported up to 65.6%, and biochemical recurrence ranged from 0 to 57%. Conclusion: Salvage robotic-assisted radical prostatectomy in patients with cancer recurrence after previous prostate cancer treatment is safe and feasible. The literature is based on retrospective studies with inherent limitations describing low rates of intraoperative complications and small blood loss. However, potency and continence rates are largely reduced compared to the primary RARP series, despite the type of the primary treatment. Better-designed studies to assess the long-term outcomes and individually specify each primary therapy impact on the salvage treatment are still needed. Future articles should be more specifi c and provide more details regarding the previous therapies and S-RARP surgical techniques.

show abstract

Section: Functional Outcomesmentioning

confidence: 88%

Section: Functional Outcomesmentioning

confidence: 99%

Section: Evidence Synthesismentioning

confidence: 99%

See 1 more Smart Citation

Outcomes of Salvage Robotic-assisted Radical Prostatectomy in the last decade: systematic review and perspectives of referral centers.

Moschovas,

Bravi,

Dell'Oglio

et al. 2023

Int. braz j urol.

View full text Add to dashboard Cite

show abstract

Urinary Continence and Erectile Function in the Salvage Setting

Moschovas,

Patel,

Loy

et al. 2024

Urinary Continence and Sexual Function After Robotic Prostatectomy, Radiation, and Novel Therapies

View full text Add to dashboard Cite

Salvage Radical Prostatectomy for Recurrent Prostate Cancer: A Systematic Review (French ccAFU)

Saouli,

Ruffion,

Dariane

et al. 2023

Cancers

View full text Add to dashboard Cite

The aim of this study was to systematically review the current evidence regarding the oncological and functional outcomes of salvage radical prostatectomy (sRP) for recurrent prostate cancer. A systematic review was conducted throughout September 2022 using the PubMed, Science Direct, Scopus, and Embase databases. Preferred Reporting Items for Systematic Reviews and Meta-analysis (PRISMA) guidelines were followed to identify eligible studies. A total of 55 studies (3836 patients) met our eligibility criteria. The vast majority of men included had radiation therapy (including brachytherapy) as their first-line treatment (n = 3240, 84%). Other first-line treatments included HIFU (n = 338, 9%), electroporation (n = 59, 2%), proton beam therapy (n = 54, 1.5%), cryotherapy (n = 34, 1%), focal vascular targeted photodynamic therapy (n = 22, 0.6%), and transurethral ultrasound ablation (n = 19, 0.5%). Median preoperative PSA, at the time of recurrence, ranged from 1.5 to 14.4 ng/mL. The surgical approach was open in 2300 (60%) cases, robotic in 1465 (38%) cases, and laparoscopic in 71 (2%) cases. Since 2019, there has been a clear increase in robotic versus conventional surgery (1245 versus 525 cases, respectively). The median operative time and blood loss ranged from 80 to 297 min and 75 to 914 mL, respectively. Concomitant lymph node dissection was performed in 2587 cases (79%). The overall complication rate was 34%, with a majority of Clavien grade I or II complications. Clavien ≥ 3 complications ranged from 0 to 64%. Positive surgical margins were noted in 792 cases (32%). The median follow-up ranged from 4.6 to 94 months. Biochemical recurrence after sRP ranged from 8% to 51.5% at 12 months, from 0% to 66% at 22 months, and from 48% to 59% at 60 months. The specific and overall survival rates ranged from 13.4 to 98% and 62 to 100% at 5 years, respectively. Urinary continence was maintained in 52.1% of cases. sRP demonstrated acceptable oncological outcomes. These results, after sRP, are influenced by several factors, and above all by pre-treatment assessment, including imaging, with the development of mpMRI and metabolic imaging. Our results demonstrated that SRP can be considered a suitable treatment option for selected patients, but the level of evidence remains low.

show abstract

Introduction of salvage prostatectomy in Denmark: the initial experience

Cited by 3 publications

References 19 publications

Outcomes of Salvage Robotic-assisted Radical Prostatectomy in the last decade: systematic review and perspectives of referral centers.

Outcomes of Salvage Robotic-assisted Radical Prostatectomy in the last decade: systematic review and perspectives of referral centers.

Urinary Continence and Erectile Function in the Salvage Setting

Salvage Radical Prostatectomy for Recurrent Prostate Cancer: A Systematic Review (French ccAFU)

Contact Info

Product

Resources

About