Introduction: Pseudomonas aeruginosa, an opportunist pathogen

Clarke, Paul

doi:10.1007/978-94-009-1836-8_1

Cited by 4 publications

(4 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Aside from being a deterioration microorganism, psychrotrophic microbes (Pseudomonas spp) could cause urinary and circulation system disease. This is because of the way that they foster protection from specific anti-infection agents (Clarke, 1990).…”

Section: Introductionmentioning

confidence: 99%

Evaluation of the microbial quality of some chicken meat products in EL-Gharbia governorate, Egypt.

Esmail¹

2022

Benha Veterinary Medical Journal

View full text Add to dashboard Cite

A grand total of randomly hundred samples of poultry meat products (fresh pane, luncheon, burger and popcorn) 25 of each were collected from various supermarkets in different cities at Gharbia Governorate, Egypt for bacteriological examination of aerobic plate count, Staphylococcal, Enterobacteriaceae, Psychrotrophic, Coliform and Yeast and Mold counts (cfu/g) which were 3.6×10 5 ± 1.9×10 5 , 4.2×10 2 ±1.2×10, 1.9×10 3 ± 1.1×10 2 , 1.9×10 3 ± 1×10 2 , 4.3×10 2 ± 1.1×10 and 2.2×10 2 ± 2.1×10 in fresh pane, 2.2×10 5 ± 1.3×10 5 , 3.8×10 2 ± 1.3×10, 2.03×10 3 ± 1.01×10 2 , 3×10 3 ± 2.2×10 2 , 5.2×10 2 ± 1.02×10 2 and 2×10 2 ± 1.6×10 in luncheon, 4.2×10 4 ± 1.2×10 3 , 4.8×10 2 ± 1×10 2 , 1.5×10 2 ± 1.1×10 2 , 1.8×10 2 ± 1.1×10 2 , 3.3×10 2 ± 1.6×10 and 1.06×10 2 ± 0.5 in burger, 3.7×10 4 ± 2.1×10 3 , 3.9×10 3 ± 1.5×10 2 , 2.8×10 2 ± 1.2×10, 3.01×10 2 ± 0.5×10, 2.03×10 2 ± 1.2×10 and 3.3×10 2 ± 1.2×10 in popcorn samples, respectively. Also, the incidence of coagulase positive Staphylococcus aureus isolated from fresh pane, luncheon, burger, and popcorn were 23.17%, 39.70%, 23.07% and 47.14% respectively. Moreover, fifteen isolates of E. coli serotypes were isolated from examined samples represented as E. coli O78 (46.66%), E. coli O124 (13.33%), E. coli O114(13.33%), E coli O128:H2 (6.66%) and E coli O142 (20%). The importance of the isolated microorganism and the recommended requirements to prevent or even minimize contamination of chicken meat product were discussed APC Chicken meatFood borne pathogens

show abstract

Section: Introductionmentioning

confidence: 99%

Evaluation of the microbial quality of some chicken meat products in EL-Gharbia governorate, Egypt.

Esmail¹

2022

Benha Veterinary Medical Journal

View full text Add to dashboard Cite

show abstract

“…seudomonas aeruginosa is an opportunistic human pathogen that causes an acute lung disease with high mortality in seriously ill and immunocompromised patients (1)(2)(3)(4). P. aeruginosa is also commonly associated with a chronic, progressive lung disease in individuals with cystic fibrosis (CF) 3 (5-7).…”

mentioning

confidence: 99%

Pyocyanin and Its Precursor Phenazine-1-Carboxylic Acid Increase IL-8 and Intercellular Adhesion Molecule-1 Expression in Human Airway Epithelial Cells by Oxidant-Dependent Mechanisms

Look¹,

Stoll²,

Romig³

et al. 2005

The Journal of Immunology

View full text Add to dashboard Cite

Pseudomonas aeruginosa secretes numerous factors that alter host cell function and may contribute to disease pathogenesis. Among recognized virulence factors is the redox-active phenazine pyocyanin. We have recently demonstrated that the precursor for pyocyanin, phenazine-1-carboxylic acid (PCA), increases oxidant formation and alters gene expression in human airway epithelial cells. We report in this work that PCA and pyocyanin increase expression of ICAM-1 both in vivo and in vitro. Moreover, phenazines enhanced cytokine-dependent increases in IL-8 and ICAM-1. Antioxidant intervention studies indicated both similarities and differences between PCA and pyocyanin. The thiol antioxidant N-acetyl cysteine, extracellular catalase, and inducible NO synthase inhibitors inhibited ICAM-1 and IL-8 increases in response to both phenazines. However, pyocyanin was significantly more sensitive to N-acetylcysteine inhibition. Interestingly, hydroxyl radical scavengers inhibited the response to pyocyanin, but not to PCA. These studies suggest that P. aeruginosa phenazines coordinately up-regulate chemokines (IL-8) and adhesion molecules (ICAM-1) by mechanisms that are, at least in part, oxidant dependent. However, results indicate that the mechanisms by which PCA and pyocyanin exert their effects are not identical, and not all antioxidant interventions are equally effective in inhibiting phenazine-mediated proinflammatory effects.

show abstract

“…aeruginosa is a highly adaptable microorganism that survives in a variety of limiting environments (4). Among the features that make it so successful is the production of a large array of secretory factors, including proteases, exotoxins, phospholipases, and pigments (5,6). Many of these secretory factors have been shown to have biologic effects on host cells that may contribute to the pathogenesis of P. aeruginosa -associated lung disease.…”

mentioning

confidence: 99%

Small Molecular Weight Secretory Factors fromPseudomonas aeruginosaHave Opposite Effects on IL-8 and RANTES Expression by Human Airway Epithelial Cells

Leidal

Munson

Denning

2001

Am J Respir Cell Mol Biol

View full text Add to dashboard Cite

Pseudomonas aeruginosa is an opportunistic human pathogen that causes both an acute lung disease in patients with hospital-acquired pneumonia and a chronic lung disease in individuals with cystic fibrosis. Many of the pathophysiologic effects of P. aeruginosa infection are due to factors secreted by the bacterium. Conditioned media from cultures of P. aeruginosa increased interleukin-8 expression and decreased regulated on activation, normal T cells expressed and secreted (RANTES) expression by human airway epithelial cells. Both of these activities were present in heat-treated, protease-treated, small molecular weight fractions. The activities were not inhibited by polymyxin B and were not extracted into ethyl acetate, suggesting that they were not due to endotoxin or autoinducer. Conversely, results from chloroform extractions and studies with a phenazine-minus mutant suggested that the blue pigment pyocyanin contributes to these activities when present. In addition to the effects of small molecular weight factors on cytokine expression, proteases in bacterial-conditioned media further decreased levels of RANTES. By altering expression, release, and/or activity of inflammatory cytokines, secretory factors from P. aeruginosa could disrupt the delicate balance that constitutes the immune response to bacterial infection and thus could contribute to the lung damage that occurs in P. aeruginosa-infected airways.

show abstract

Introduction: Pseudomonas aeruginosa, an opportunist pathogen

Cited by 4 publications

References 31 publications

Evaluation of the microbial quality of some chicken meat products in EL-Gharbia governorate, Egypt.

Evaluation of the microbial quality of some chicken meat products in EL-Gharbia governorate, Egypt.

Pyocyanin and Its Precursor Phenazine-1-Carboxylic Acid Increase IL-8 and Intercellular Adhesion Molecule-1 Expression in Human Airway Epithelial Cells by Oxidant-Dependent Mechanisms

Small Molecular Weight Secretory Factors fromPseudomonas aeruginosaHave Opposite Effects on IL-8 and RANTES Expression by Human Airway Epithelial Cells

Contact Info

Product

Resources

About