Introduction to biology and chromosomal instabilities in cancer

Kroll, K. M; Ferrantini, Alessandro; Domany, Eytan

doi:10.1016/j.physa.2010.03.023

Cited by 1 publication

(1 citation statement)

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“…Cancer is a disease recognized by uncontrolled cell division to make a malignant tumor that can invade cells and tissues in a process called metastasis . This is the second main cause of death worldwide, causing 9.6 million deaths. , Cancer has various types, and liver cancer is the fourth cause of death followed by breast cancer in the United States . Liver cancer has two types; the first one is primary liver cancer that starts in liver cells such as hepatocellular carcinoma that mainly affects the adults.…”

Section: Introductionmentioning

confidence: 99%

Bioactivity Studies of Hesperidin and XAV939

et al. 2021

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The present work aimed to evaluate the reactivity of natural bioflavonoid hesperidin (HSP) and synthetically derived XAV939 (XAV) against human hepatocellular carcinoma (HepG2), human breast cancer (MDA-MB231) cancer cell lines, and related molecular and pathological profiles. Data recorded revealed that the cytotoxic potential of the tested products was found to be cell type-and concentration-dependent. The halfmaximal inhibitory concentration (IC 50 ) value of the HSP-XAV mixture against MDA-MB231 was significantly decreased in the case of using the HSP-XAV mixture against the HepG2 cell line. Also, there was a significant upregulation of the phosphotumor suppressor protein gene (P53) and proapoptotic genes such as B-cell lymphomaassociated X-protein (Bax, CK, and Caspase-3), while antiapoptotic gene B-cell lymphoma (Bcl-2) was significantly downregulated compared with the untreated cell control. The cell cycle analysis demonstrated that DNA accumulation was detected mainly during the G2/ M phase of the cell cycle accompanied with the elevated reactive oxygen species level in the treatment of HepG2 and MDA-MB231 cell lines by the HSP-XAV mixture, more significantly than that in the case of cell control. Finally, our finding suggests that both HSP and XAV939 and their mixture may offer an alternative in human liver and breast cancer therapy.

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Section: Introductionmentioning

confidence: 99%