Introduction to Blood Transfusion Technology

Armstrong, Beryl; Hardwick, Jonathan; Raman, Leesha; Smart, Elizabeth; Wilkinson, Robert

doi:10.1111/j.1751-2824.2008.00197.x

Cited by 9 publications

(11 citation statements)

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“…The predominant method in Europe is the buffy‐coat (BC) method and in the United States the platelet rich plasma (PRP) method [4]. The two methods mainly differ in the centrifugation steps and have been described in detail in a recent publication in this Journal [5]. For production of pooled PCs from BC either the pooling kit method or the chain method can be used [5], also there are manual and automated methods of pooling [5–7].…”

Section: Introductionmentioning

confidence: 99%

“…The two methods mainly differ in the centrifugation steps and have been described in detail in a recent publication in this Journal [5]. For production of pooled PCs from BC either the pooling kit method or the chain method can be used [5], also there are manual and automated methods of pooling [5–7]. Pooled platelets prepared by the BC method are usually stored in additive solution rather than in plasma making more plasma available for clinical use and reducing the plasma‐associated transfusion reactions [8].…”

Section: Introductionmentioning

confidence: 99%

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Buffy-coat-derived pooled platelet concentrates and apheresis platelet concentrates: which product type should be preferred?

2010

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There is an ongoing debate whether platelet concentrates (PCs) prepared from either whole-blood donations or by plateletpheresis are superior. Usage of these two product types varies greatly between countries and individual institutions. Some use mainly apheresis PCs; others prefer pooled PCs which are produced from whole-blood donations. This review summarizes the existing information on these product types. In the first part data on quality, efficacy and safety are reviewed. It is important to note that the issue cannot be answered just by comparing 'the' apheresis platelet concentrate versus 'the' pooled platelet concentrate. Other factors which determine the quality of a product, e.g. residual leukocyte count, plasma content, additive solution or storage period may be even more important. The focus of the debate should be shifted. It is much more needed to further improve the overall quality of PCs and to optimize treatment of thrombocytopenic patients than to concentrate on a single-edged view on just the preparation method. In the second part of this review we compare the product types from the donor's point of view. If PCs which are equally safe and effective can be obtained by various methods, ethics and the safety of the healthy volunteer donor tips the scales. The decision on the use of a particular product type should take into account all aspects of efficacy, side effects and availability of the product as well as the donor's perspective and the commitment to maximize the use of the valuable whole-blood donation.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Buffy-coat-derived pooled platelet concentrates and apheresis platelet concentrates: which product type should be preferred?

2010

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“…Der gewonnene BC wird anschließend langsam zentrifugiert und das TK wird aus dem Überstand gewonnen. Alternativ wird die Vollblutspende langsam zentrifugiert und bei der Komponentenauftrennung wird ein plättchenreiches Plasma (PRP) gewonnen, das wiederum durch schnelle Zentrifugation und Resuspension der Thrombozyten zum TK wird [6,7]. Die in Deutschland eingesetzten PTK werden ausschließlich mit der BC-Methode hergestellt, in den USA wird die Plätt-chenreiches-Plasma-(PRP) Methode bevorzugt [8].…”

Section: Herstellung Von Pool-tkunclassified

“…Kalkuliert aus den Daten gemäß § 21 Transfusionsgesetz (TFG) entspricht das einem Anteil von maximal 1,25 % aller 2013 in Deutschland hergestellten PTK. International wird ein Pooling der BC aus 4 bis 6 Vollblutspenden berichtet [7].…”

Section: Herstellung Von Pool-tkunclassified

Wissenschaftliche Erläuterungen zur Stellungnahme „Bewertung von Apherese- und Pool-Thrombozytenkonzentraten“ des AK Blut vom 31.03.2015

2015

Bundesgesundheitsbl.

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“…It is important to employ a systematic approach to antibody exclusion in the process of antibody identification. Several reagent RBC panels may be needed to identify some combinations of antibodies [7].…”

Section: Other Blood Group Systemsmentioning

confidence: 99%

Blood group serology

Goubran

2009

ISBT Science Series

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Introduction to Blood Transfusion Technology

Cited by 9 publications

References 0 publications

Buffy-coat-derived pooled platelet concentrates and apheresis platelet concentrates: which product type should be preferred?

Buffy-coat-derived pooled platelet concentrates and apheresis platelet concentrates: which product type should be preferred?

Wissenschaftliche Erläuterungen zur Stellungnahme „Bewertung von Apherese- und Pool-Thrombozytenkonzentraten“ des AK Blut vom 31.03.2015

Blood group serology

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