Introduction to medical materials and devices

Ramsden, Jeremy J.

doi:10.1533/9780857096425.1.3

Cited by 4 publications

(1 citation statement)

References 40 publications

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“…Titanium is often applied for medical applications, such as for prostheses and dental implants [25,28,181]. This is possible due to the good mechanical strength, excellent corrosion resistance, and extraordinary biocompatibility of Ti [182].…”

Section: Titanium As Reference Electrode Materials and Titanium Dioxi...mentioning

confidence: 99%

Systematic assessment of the biocompatibility of materials for inkjet-printed ozone sensors for medical therapy

Petani

Wehrheim

Koker

et al. 2021

Flex. Print. Electron.

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The biocompatibility of medical sensors is of great importance. In order to prevent harm of the patient during measurement, this aspect must be considered throughout the entire design process. Biocompatibility can be achieved by various methods. For example, the sensor can be encapsulated, only biocompatible materials can be used for the sensor, or anti-inflammatory agents can be applied to the surface of the sensor. In this paper the focus is on sensors fully fabricated from biocompatible materials. Two exemplary inkjet-printed amperometric and impedimetric sensors are systematically assessed regarding their biocompatibility. Both sensors can be used for the measurement of dissolved ozone during oxygen-ozone injection therapy. For the sensors each material is evaluated with respect to the international standard ISO 10993. Overall, many amperometric and impedimetric sensors are fabricated from a small set of materials. The assessment reveals that for this specific application an amperometric sensor consisting of gold and silver nanoparticle inks, inkjet-printed on a polydimethylsiloxane membrane, and passivated with SU-8 ink offers the highest biocompatibility and reaches a good compliance with other important requirements. In addition, biological characterization tests are required for the specific medical application to validate the biocompatibility. From this study, it can be concluded that the findings on biocompatibility can also be transferred to other sensors that are made of the same set of materials but are for other applications. This applies to oxygen, glucose, pH, hydrogen peroxide, sweat lactate, and acetone sensors.

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Section: Titanium As Reference Electrode Materials and Titanium Dioxi...mentioning

confidence: 99%

Systematic assessment of the biocompatibility of materials for inkjet-printed ozone sensors for medical therapy

Petani

Wehrheim

Koker

et al. 2021

Flex. Print. Electron.

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Candida albicans aspects of binary titanium alloys for biomedical applications

Chen

Tsoi

Tsang

et al. 2020

Regenerative Biomaterials

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Titanium and its alloys are widely used in biomedical devices, e.g. implants, due to its biocompatibility and osseointegration ability. In fact, fungal (Candida spp.) infection has been identified as one of the key reasons causing the failure of the device that is inevitable and impactful to the society. Thus, this study evaluated the surface morphology, surface chemical composition and Candida albicans adhesion on specimens of 16 binary Ti-alloys (∼5 wt% of any one of the alloy elements: Ag, Al, Au, Co, Cr, Cu, Fe, In, Mn, Mo, Nb, Pd, Pt, Sn, V and Zr) compared with cp-Ti, targeting to seek for the binary Ti-alloys which has the lowest C. albicans infection. Candida albicans cultures were grown on the specimens for 48 h, and colony forming units (CFUs) and real-time polymerase chain reaction (RT-PCR) were used to evaluate the biofilm formation ability. Scanning electron microscopy and confocal laser scanning microscopy confirmed the formation of C. albicans biofilm on all specimens’ surfaces, such that CFU results showed Ti-Mo, Ti-Zr, Ti-Al and Ti-V have less C. albicans formed on the surfaces than cp-Ti. RT-PCR showed Ti-Zr and Ti-Cu have significantly higher C. albicans DNA concentrations than Ti-Al and Ti-V (P < 0.05), whereas Ti-Cu has even showed a statistically higher concentration than Ti-Au, Ti-Co, Ti-In and Ti-Pt (P < 0.05). This study confirmed that Ti-Mo, Ti-Zr, Ti-Al and Ti-V have lower the occurrence of C. albicans which might be clinically advantageous for medical devices, but Ti-Cu should be used in caution.

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Inductance-geometry Relation in the Flat Concentric Coils

Khertek

Данилов

2021

2021 IEEE Conference of Russian Young Researchers in Electrical and Electronic Engineering (ElConRus)

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Introduction to medical materials and devices

Cited by 4 publications

References 40 publications

Systematic assessment of the biocompatibility of materials for inkjet-printed ozone sensors for medical therapy

Systematic assessment of the biocompatibility of materials for inkjet-printed ozone sensors for medical therapy

Candida albicans aspects of binary titanium alloys for biomedical applications

Inductance-geometry Relation in the Flat Concentric Coils

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