The paper analyses the influence of pressure and temperature of gas and liquid on the process of hydrate formation, proposes equations that allow to predict the course of heat and mass exchange processes of gas hydrate synthesis and estimate the amount of gas hydrate obtained at given thermodynamic parameters. The synthesis of gas hydrates begins with the creation of appropriate thermodynamic conditions in the reactor. However, the formation of hydrate layers on the surfaces of gas bubbles in bubbling or high-speed mixing technologies has peculiarities associated with the fact that the temperature and pressure of the gas change depending on the bubble size fluctuations. This should be taken into account when determining the conditions of hydrate formation. To this end, the article proposes a mathematical model that allows the thermodynamic conditions of synthesis to be optimised. The obtained results can be used to design process equipment and optimise its parameters.